Antibiotic resistance and extended spectrum beta-lactamases: Types, epidemiology and treatment.
Reads0
Chats0
TLDR
The carbapenems are widely regarded as the drugs of choice for the treatment of severe infections caused by ESBL-producing Enterobacteriaceae, although comparative clinical trials are scarce and the feasible modification of guidelines for community-onset bacteremia associated with different infections are prescribed.About:
This article is published in Saudi Journal of Biological Sciences.The article was published on 2015-01-01 and is currently open access. It has received 534 citations till now. The article focuses on the topics: Antibiotic resistance & Antimicrobial.read more
Citations
More filters
Journal ArticleDOI
Epidemiology of resistance and phenotypic characterization of carbapenem resistance mechanisms in Klebsiella pneumoniae isolates at Sahloul University Hospital-Sousse, Tunisia.
Aziza Messaoudi,Wejdene Mansour,Nedia Jaidane,Chrifa Chaouch,Noureddine Boujaâfar,Olfa Bouallegue +5 more
TL;DR: Resistance of Enterobacteriaceae, including K. pneumoniae, to third generation cephalosporins (3rd GC) and carbapenem through the mechanism of ESBL and carbAPenemases production is becoming increasingly worrying and suggests a more rational use of antibiotics, as well as the rigorous application of hygiene measurement.
Journal ArticleDOI
Increased (Antibiotic-Resistant) Pathogen Indicator Organism Removal during (Hyper-)Thermophilic Anaerobic Digestion of Concentrated Black Water for Safe Nutrient Recovery
Marinus J. Moerland,Alicia Borneman,Paraschos Chatzopoulos,Adrian Gonzalez Fraile,Miriam H. A. van Eekert,Grietje Zeeman,Cees J.N. Buisman +6 more
TL;DR: In this paper, the authors presented results showing that thermophilic and hyperthermophilic anaerobic treatments had higher (antibiotic-resistant) culturable pathogen indicators removal than mesophilic treatment.
Journal ArticleDOI
High Throughput Virtual Screening and Molecular Dynamics Simulation for Identifying a Putative Inhibitor of Bacterial CTX-M-15
TL;DR: In this article, a promising anti-CTX-M-15 ligand whose chemical skeleton could be used as a "seed-molecule" for future drug design against resistant bacteria was identified.
Journal ArticleDOI
Rapid detection of Klebsiella pneumoniae producing extended spectrum β lactamase enzymes by infrared microspectroscopy and machine learning algorithms.
Manal Suleiman,George Abu-Aqil,Uraib Sharaha,Klaris Riesenberg,Orli Sagi,Itshak Lapidot,Mahmoud Huleihel,Ahmad Salman +7 more
TL;DR: In this article, the authors evaluated the potential of infrared microspectroscopy in tandem with machine learning algorithms for rapid detection of Extended Spectrum Beta-Lactamase-producing (ESBL+) bacteria.
Journal ArticleDOI
Extended-Spectrum Beta-Lactamase Infections in Orthopedic-Related Devices and Prosthetic Joints.
TL;DR: The clinical characteristics, risk factors, and outcomes of patients with extended-spectrum beta-lactamase-producing Enterobacteriaceae infections of prosthetic joints or orthopedic-related hardware, and the use of carbapenems remains effective in these cases are reviewed.
References
More filters
Journal ArticleDOI
Extended-spectrum beta-lactamases: a clinical update.
TL;DR: Extended-spectrum β-lactamases represent an impressive example of the ability of gram-negative bacteria to develop new antibiotic resistance mechanisms in the face of the introduction of new antimicrobial agents.
Journal ArticleDOI
Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study
Karthikeyan Kumarasamy,Mark Toleman,Timothy R. Walsh,Jay Bagaria,Fafhana Butt,Ravikumar Balakrishnan,Uma Chaudhary,Michel Doumith,Christian G. Giske,Seema Irfan,Padma Krishnan,Anil Kumar,Sunil Maharjan,Shazad Mushtaq,Tabassum Noorie,David L. Paterson,A. Pearson,Claire Perry,Rachel Pike,Bhargavi Rao,Ujjwayini Ray,Jayanta B. Sarma,Madhu Sharma,Elizabeth Sheridan,M A Thirunarayan,Jane F. Turton,Supriya Upadhyay,Marina Warner,William Welfare,David M. Livermore,Neil Woodford +30 more
TL;DR: The prevalence of NDM-1, in multidrug-resistant Enterobacteriaceae in India, Pakistan, and the UK is investigated, and co-ordinated international surveillance is needed.
Journal ArticleDOI
Extended-Spectrum β-Lactamases in the 21st Century: Characterization, Epidemiology, and Detection of This Important Resistance Threat
TL;DR: β-Lactamases continue to be the leading cause of resistance to β-lactam antibiotics among gram-negative bacteria and are now found in a significant percentage of Escherichia coli and Klebsiella pneumoniae strains in certain countries.
Journal ArticleDOI
A functional classification scheme for beta-lactamases and its correlation with molecular structure.
TL;DR: These enzymes are the major cause of bacterial resistance to b-lactam antibiotics and have been the subject of extensive microbiological, biochemical, and genetic investigations.
Journal ArticleDOI
beta-Lactamases in laboratory and clinical resistance.
TL;DR: The ability of the prevalent beta-Lactamases to cause resistance to widely used beta-lactams, whether resistance is accurately reflected in routine tests, and the extent to which the antibiogram for an organism can be used to predict the type of beta- lactamase that it produces are considered.
Related Papers (5)
Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance
A-P Magiorakos,Arjun Srinivasan,R B Carey,Yehuda Carmeli,Matthew E. Falagas,Matthew E. Falagas,Christian G. Giske,Stéphan Juergen Harbarth,Janet F. Hindler,Gunnar Kahlmeter,Barbro Olsson-Liljequist,David L. Paterson,Louis B. Rice,John Stelling,Marc Struelens,Alkiviadis Vatopoulos,J T Weber,Dominique L Monnet +17 more