Antibiotic resistance and extended spectrum beta-lactamases: Types, epidemiology and treatment.
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TLDR
The carbapenems are widely regarded as the drugs of choice for the treatment of severe infections caused by ESBL-producing Enterobacteriaceae, although comparative clinical trials are scarce and the feasible modification of guidelines for community-onset bacteremia associated with different infections are prescribed.About:
This article is published in Saudi Journal of Biological Sciences.The article was published on 2015-01-01 and is currently open access. It has received 534 citations till now. The article focuses on the topics: Antibiotic resistance & Antimicrobial.read more
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Journal ArticleDOI
New York City House Mice (Mus musculus) as Potential Reservoirs for Pathogenic Bacteria and Antimicrobial Resistance Determinants.
Simon H. Williams,Xiaoyu Che,Ashley Paulick,Cheng Guo,Bohyun Lee,Dorothy R. Muller,Anne-Catrin Uhlemann,Franklin D. Lowy,Robert M. Corrigan,W. Ian Lipkin +9 more
TL;DR: The fecal microbiome of house mice in New York City is described with emphasis on detection of pathogenic bacteria and antimicrobial resistance genes by molecular methods, and mice are carriers of several gastrointestinal disease-causing agents including Shigella, Salmonella, Clostridium difficile, and diarrheagenic Escherichia coli.
Journal ArticleDOI
Nanotechnology as a Novel Approach in Combating Microbes Providing an Alternative to Antibiotics
Bismillah Mubeen,Aunza Nayab Ansar,Rabia Rasool,Inam Ullah,Syed Sarim Imam,Sultan Alshehri,Mohammed M. Ghoneim,Sami I. Alzarea,Muhammad Nadeem,Imran Kazmi +9 more
TL;DR: In this paper, the antimicrobial effects of nanoparticles and contrasts nanoparticles' with antibiotics' role in the fight against pathogenic microorganisms are discussed. And the authors highlight the potential of nanomaterials for infection prevention, diagnosis, treatment and biofilm control.
Book ChapterDOI
Antimicrobial Resistance in the Food Chain in the European Union.
TL;DR: The European Union surveillance program currently includes the animal species with the highest meat production and the food derived from them, investigating antimicrobial resistance of zoonotic and indicator bacteria.
Journal ArticleDOI
Tackling the Antibiotic Resistance Caused by Class A β-Lactamases through the Use of β-Lactamase Inhibitory Protein.
TL;DR: This article represents the first systematic review on β-lactamase inhibitors with a particular focus on BLIPs and their inherent properties that favorably position them as a source of biologically-inspired drugs to combat antimicrobial resistance.
Journal ArticleDOI
Carriage of beta-lactamase-producing Enterobacteriaceae among nursing home residents in north Lebanon
TL;DR: The high prevalence of MDR Enterobacteriaceae detected in this study and the emergence of carbapenem resistance is alarming and efficient infection control measures and antibiotic stewardship programs are urgently needed in these settings in order to limit the spread of resistant strains.
References
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Journal ArticleDOI
Extended-spectrum beta-lactamases: a clinical update.
TL;DR: Extended-spectrum β-lactamases represent an impressive example of the ability of gram-negative bacteria to develop new antibiotic resistance mechanisms in the face of the introduction of new antimicrobial agents.
Journal ArticleDOI
Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study
Karthikeyan Kumarasamy,Mark Toleman,Timothy R. Walsh,Jay Bagaria,Fafhana Butt,Ravikumar Balakrishnan,Uma Chaudhary,Michel Doumith,Christian G. Giske,Seema Irfan,Padma Krishnan,Anil Kumar,Sunil Maharjan,Shazad Mushtaq,Tabassum Noorie,David L. Paterson,A. Pearson,Claire Perry,Rachel Pike,Bhargavi Rao,Ujjwayini Ray,Jayanta B. Sarma,Madhu Sharma,Elizabeth Sheridan,M A Thirunarayan,Jane F. Turton,Supriya Upadhyay,Marina Warner,William Welfare,David M. Livermore,Neil Woodford +30 more
TL;DR: The prevalence of NDM-1, in multidrug-resistant Enterobacteriaceae in India, Pakistan, and the UK is investigated, and co-ordinated international surveillance is needed.
Journal ArticleDOI
Extended-Spectrum β-Lactamases in the 21st Century: Characterization, Epidemiology, and Detection of This Important Resistance Threat
TL;DR: β-Lactamases continue to be the leading cause of resistance to β-lactam antibiotics among gram-negative bacteria and are now found in a significant percentage of Escherichia coli and Klebsiella pneumoniae strains in certain countries.
Journal ArticleDOI
A functional classification scheme for beta-lactamases and its correlation with molecular structure.
TL;DR: These enzymes are the major cause of bacterial resistance to b-lactam antibiotics and have been the subject of extensive microbiological, biochemical, and genetic investigations.
Journal ArticleDOI
beta-Lactamases in laboratory and clinical resistance.
TL;DR: The ability of the prevalent beta-Lactamases to cause resistance to widely used beta-lactams, whether resistance is accurately reflected in routine tests, and the extent to which the antibiogram for an organism can be used to predict the type of beta- lactamase that it produces are considered.
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