Antibiotic resistance and extended spectrum beta-lactamases: Types, epidemiology and treatment.
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TLDR
The carbapenems are widely regarded as the drugs of choice for the treatment of severe infections caused by ESBL-producing Enterobacteriaceae, although comparative clinical trials are scarce and the feasible modification of guidelines for community-onset bacteremia associated with different infections are prescribed.About:
This article is published in Saudi Journal of Biological Sciences.The article was published on 2015-01-01 and is currently open access. It has received 534 citations till now. The article focuses on the topics: Antibiotic resistance & Antimicrobial.read more
Citations
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Journal ArticleDOI
Detection of Pan drug resistance OXA-48 producing Providencia in an ICU patient for the first time in Nepal.
Ranjit Sah,Shusila Khadka,Gentle Sunder Shrestha,Subhash Prasad Acharya,Diptesh Aryal,Pramesh Sunder Shrestha,Hari Prasad Kattel,Niranjan Prasad Shah,Bharat Mani Pokhrel,Yogendra Prasad Singh,Basista Prasad Rijal,Hakan Erdem +11 more
TL;DR: Carbapenamase production along with intrinsic colistin resistance in infecting bacterial pathogens can cause fatal outcomes in the resource limited countries like Nepal where new antibiotic combinations ceftazidime+ Avibactam, or aztreonam +avibactsam are not available.
Journal ArticleDOI
Implicancias Estructurales y Fisiológicas de la Célula Bacteriana en los Mecanismos de Resistencia Antibiótica
Claudia Troncoso,Claudia Troncoso,Mónica Pavez,Andrés Santos,Rodrigo Salazar,Leticia Barrientos +5 more
TL;DR: In this paper, the authors present a revisión of the implicancias estructurales y fisiológicas de the célula bacteriana en los mecanismos de resistencia antibiótica, considerando the organización estructures and fisio-gicciógicos of bacterias.
Journal ArticleDOI
Genotyping and antimicrobial resistance in Escherichia coli from pig carcasses
Caroline Pissetti,Gabriela Orosco Werlang,Jalusa Deon Kich,Marisa Ribeiro de Itapema Cardoso +3 more
TL;DR: The study showed that resistance to antimicrobials is widespread in E. coli isolated from pig carcasses, since 86.2% of the strains were resistant to at least one antimicrobial and 71% displayed multi-resistance profiles.
Journal ArticleDOI
Resistencia antimicrobiana y genotipificación de cepas de salmonella typhimurium aisladas de cuyes (Cavia porcellus) provenientes de granjas de producción intensiva de la ciudad de Lima, Perú
R Guillermo Salvatierra,B Rocío Rímac,O Ana Chero,W Iván Reyna,A Raúl Rosadio,H Lenin Maturrano +5 more
TL;DR: La deteccion de cepas resistentes puede ocasionar problemas en el tratamiento de salmonelosis en cuyes y the presencia of un solo grupo genetico sugiere una dispersion clonal.
Journal ArticleDOI
Detection of presumed genes encoding beta-lactamases by sequence based screening of metagenomes derived from Antarctic microbial mats
Gastón Azziz,Matías Giménez,Héctor Romero,Patricia M. Valdespino-Castillo,Luisa I. Falcón,Lucas Ruberto,Walter P. Mac Cormack,Silvia Cristina Freitas Batista +7 more
TL;DR: The results suggest that environmental diversity of beta-lactamase genes is higher than that currently reported, although this should be complemented with gene function analysis, as this is a major challenge of public health worldwide.
References
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Journal ArticleDOI
Extended-spectrum beta-lactamases: a clinical update.
TL;DR: Extended-spectrum β-lactamases represent an impressive example of the ability of gram-negative bacteria to develop new antibiotic resistance mechanisms in the face of the introduction of new antimicrobial agents.
Journal ArticleDOI
Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study
Karthikeyan Kumarasamy,Mark Toleman,Timothy R. Walsh,Jay Bagaria,Fafhana Butt,Ravikumar Balakrishnan,Uma Chaudhary,Michel Doumith,Christian G. Giske,Seema Irfan,Padma Krishnan,Anil Kumar,Sunil Maharjan,Shazad Mushtaq,Tabassum Noorie,David L. Paterson,A. Pearson,Claire Perry,Rachel Pike,Bhargavi Rao,Ujjwayini Ray,Jayanta B. Sarma,Madhu Sharma,Elizabeth Sheridan,M A Thirunarayan,Jane F. Turton,Supriya Upadhyay,Marina Warner,William Welfare,David M. Livermore,Neil Woodford +30 more
TL;DR: The prevalence of NDM-1, in multidrug-resistant Enterobacteriaceae in India, Pakistan, and the UK is investigated, and co-ordinated international surveillance is needed.
Journal ArticleDOI
Extended-Spectrum β-Lactamases in the 21st Century: Characterization, Epidemiology, and Detection of This Important Resistance Threat
TL;DR: β-Lactamases continue to be the leading cause of resistance to β-lactam antibiotics among gram-negative bacteria and are now found in a significant percentage of Escherichia coli and Klebsiella pneumoniae strains in certain countries.
Journal ArticleDOI
A functional classification scheme for beta-lactamases and its correlation with molecular structure.
TL;DR: These enzymes are the major cause of bacterial resistance to b-lactam antibiotics and have been the subject of extensive microbiological, biochemical, and genetic investigations.
Journal ArticleDOI
beta-Lactamases in laboratory and clinical resistance.
TL;DR: The ability of the prevalent beta-Lactamases to cause resistance to widely used beta-lactams, whether resistance is accurately reflected in routine tests, and the extent to which the antibiogram for an organism can be used to predict the type of beta- lactamase that it produces are considered.
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