Antibiotic resistance and extended spectrum beta-lactamases: Types, epidemiology and treatment.
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TLDR
The carbapenems are widely regarded as the drugs of choice for the treatment of severe infections caused by ESBL-producing Enterobacteriaceae, although comparative clinical trials are scarce and the feasible modification of guidelines for community-onset bacteremia associated with different infections are prescribed.About:
This article is published in Saudi Journal of Biological Sciences.The article was published on 2015-01-01 and is currently open access. It has received 534 citations till now. The article focuses on the topics: Antibiotic resistance & Antimicrobial.read more
Citations
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Journal ArticleDOI
The Distribution of ESBL-Producing Enterobacteriaceae: Leicestershire UK Compared to Worldwide
TL;DR: The Bush–Jacoby–Medeiros functional scheme takes advantage of the functional properties of the beta-lactamase enzymes to classify them, for example, their substrate and inhibitor profiles, and the Ambler Scheme shall be used from here onwards.
Journal ArticleDOI
Single Escherichia coli bacteria detection using a chemiluminescence digital microwell array chip
TL;DR: In this article , the authors proposed a chemiluminescence digital microwell array chip based on the hydrolysis of 6-Chloro-4-methylumbelliferyl-β-D-glucuronide by the β-D − glucuronidase in E. coli to achieve fast single bacterial fluorescence detection.
Journal ArticleDOI
Complications of breast cancer surgery at Conakry oncological surgery unit
TL;DR: In this article, the authors analyzed surgical complications and their impact on the prognosis of operated breast cancer patients and showed that the high risk of death was related to the occurrence of relapse and lymphedema.
Dissertation
Choosing the optimal combination of antimicrobial peptides and antibiotics to treat acute sepsis
TL;DR: A combination of AMPs/antibiotic that can potentially improve sepsis treatment in preterms is found, but more work is needed to ensure that this combination is a viable new treatment for preterm infant sepsi.
Journal ArticleDOI
Rapid Identification and Classification of Pathogens That Produce Carbapenemases and Cephalosporinases with a Colorimetric Paper-Based Multisensor.
Giulia Santopolo,Antonio Clemente,Estrella Rojo-Molinero,Antonio Oliver,Camilla Noè,R. de la Rica +5 more
TL;DR: A multisensor for identifying pathogens bearing different types of β-lactamases above the infectious dose threshold within 90 min that does not require culturing samples is proposed and validated for the diagnosis of urinary tract infections.
References
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Journal ArticleDOI
Extended-spectrum beta-lactamases: a clinical update.
TL;DR: Extended-spectrum β-lactamases represent an impressive example of the ability of gram-negative bacteria to develop new antibiotic resistance mechanisms in the face of the introduction of new antimicrobial agents.
Journal ArticleDOI
Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study
Karthikeyan Kumarasamy,Mark Toleman,Timothy R. Walsh,Jay Bagaria,Fafhana Butt,Ravikumar Balakrishnan,Uma Chaudhary,Michel Doumith,Christian G. Giske,Seema Irfan,Padma Krishnan,Anil Kumar,Sunil Maharjan,Shazad Mushtaq,Tabassum Noorie,David L. Paterson,A. Pearson,Claire Perry,Rachel Pike,Bhargavi Rao,Ujjwayini Ray,Jayanta B. Sarma,Madhu Sharma,Elizabeth Sheridan,M A Thirunarayan,Jane F. Turton,Supriya Upadhyay,Marina Warner,William Welfare,David M. Livermore,Neil Woodford +30 more
TL;DR: The prevalence of NDM-1, in multidrug-resistant Enterobacteriaceae in India, Pakistan, and the UK is investigated, and co-ordinated international surveillance is needed.
Journal ArticleDOI
Extended-Spectrum β-Lactamases in the 21st Century: Characterization, Epidemiology, and Detection of This Important Resistance Threat
TL;DR: β-Lactamases continue to be the leading cause of resistance to β-lactam antibiotics among gram-negative bacteria and are now found in a significant percentage of Escherichia coli and Klebsiella pneumoniae strains in certain countries.
Journal ArticleDOI
A functional classification scheme for beta-lactamases and its correlation with molecular structure.
TL;DR: These enzymes are the major cause of bacterial resistance to b-lactam antibiotics and have been the subject of extensive microbiological, biochemical, and genetic investigations.
Journal ArticleDOI
beta-Lactamases in laboratory and clinical resistance.
TL;DR: The ability of the prevalent beta-Lactamases to cause resistance to widely used beta-lactams, whether resistance is accurately reflected in routine tests, and the extent to which the antibiogram for an organism can be used to predict the type of beta- lactamase that it produces are considered.
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A-P Magiorakos,Arjun Srinivasan,R B Carey,Yehuda Carmeli,Matthew E. Falagas,Matthew E. Falagas,Christian G. Giske,Stéphan Juergen Harbarth,Janet F. Hindler,Gunnar Kahlmeter,Barbro Olsson-Liljequist,David L. Paterson,Louis B. Rice,John Stelling,Marc Struelens,Alkiviadis Vatopoulos,J T Weber,Dominique L Monnet +17 more