Antibiotic resistance and extended spectrum beta-lactamases: Types, epidemiology and treatment.
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TLDR
The carbapenems are widely regarded as the drugs of choice for the treatment of severe infections caused by ESBL-producing Enterobacteriaceae, although comparative clinical trials are scarce and the feasible modification of guidelines for community-onset bacteremia associated with different infections are prescribed.About:
This article is published in Saudi Journal of Biological Sciences.The article was published on 2015-01-01 and is currently open access. It has received 534 citations till now. The article focuses on the topics: Antibiotic resistance & Antimicrobial.read more
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Nanomaterials for alternative antibacterial therapy
TL;DR: In this article, a review of nanomedicines as innovative tools for combating the high rates of antimicrobial resistance is presented, which encompasses the magnitude of multidrug resistance in nosocomial infections, bacterial evasion of the host immune system, mechanisms used by bacteria to develop drug resistance and the use of nanomaterials based on metals to overcome these challenges.
Journal ArticleDOI
Mechanistic Insights into the Antimicrobial Actions of Metallic Nanoparticles and Their Implications for Multidrug Resistance
Sibhghatulla Shaikh,Nazia Nazam,Syed Mohd Danish Rizvi,Khurshid Ahmad,Mohammad Hassan Baig,Eun Ju Lee,Inho Choi +6 more
TL;DR: Based on encouraging data about the antibacterial effects of NP/antibiotic combinations, it is proposed that this concept be thoroughly researched to identify means of combating drug-resistant bacteria.
Journal ArticleDOI
Persistence and reversal of plasmid-mediated antibiotic resistance
Allison J. Lopatkin,Hannah R. Meredith,Jaydeep K. Srimani,Connor Pfeiffer,Rick Durrett,Lingchong You +5 more
TL;DR: It is shown that common conjugal plasmids, even when costly, are indeed transferred at sufficiently high rates to be maintained in the absence of antibiotics in Escherichia coli, suggesting that reducing antibiotic use alone is likely insufficient for reversing resistance.
Journal ArticleDOI
Antibiotic-Resistant Salmonella in the Food Supply and the Potential Role of Antibiotic Alternatives for Control.
TL;DR: The various antibiotic-resistant Salmonella serotypes in food animals and the food supply, factors that contributed to their emergence, their antibiotic resistance mechanisms, the public health implications of their spread through thefood supply, and the potential antibiotic alternatives for controlling them are discussed.
Journal ArticleDOI
Metagenomic compendium of 189,680 DNA viruses from the human gut microbiome.
Stephen Nayfach,David Paez-Espino,David Paez-Espino,Lee Call,Lee Call,Soo Jen Low,Hila Sberro,Natalia Ivanova,Natalia Ivanova,Amy D Proal,Michael A. Fischbach,Ami S. Bhatt,Philip Hugenholtz,Nikos C. Kyrpides,Nikos C. Kyrpides +14 more
TL;DR: The Metagenomic Gut Virus catalogue as discussed by the authors contains 189,680 genomes from 11,810 publicly available human stool metagenomes and identified 54,118 candidate viral species, 92% of which were not found in existing databases.
References
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Management of multidrug-resistant organisms in health care settings, 2006.
TL;DR: This guideline is intended to provide a jumping-off point for scientists, clinicians, and policymakers to assess the appropriateness of using ultrasound for diagnosis and treatment of central nervous system disorders.
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Transferable resistance to cefotaxime, cefoxitin, cefamandole and cefuroxime in clinical isolates of Klebsiella pneumoniae and Serratia marcescens.
TL;DR: From results obtained in this study, it may be concluded that in some strains of nosocomialEnterobacteriaceae, resistance to newer cephalosporins could be transmissible and thus plasmid-located.
Book
Antibiotics: Actions, Origins, Resistance
TL;DR: This new text offers a comprehensive, up to date account of those structural classes of antibiotics that have had an impact in human infectious disease.
Journal ArticleDOI
Multiresistant Gram-negative bacteria: the role of high-risk clones in the dissemination of antibiotic resistance
TL;DR: 'high-risk clones' play a major role in the spread of resistance, with the risk lying in their tenacity--deriving from poorly understood survival traits--and a flexible ability to accumulate and switch resistance, rather than to constant resistance batteries.
Journal ArticleDOI
Increasing prevalence of ESBL-producing Enterobacteriaceae in Europe.
TL;DR: The emergence of epidemic clones harbouring several beta-lactamases simultaneously (ESBLs, metallo-beta-lacticamases or cephamycinases) and of new mechanisms of resistance to fluoroquinolones and aminoglycosides warrants future surveillance studies.
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