Journal ArticleDOI
Anticancer activity of resveratrol-loaded gelatin nanoparticles on NCI-H460 non-small cell lung cancer cells
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TLDR
RSV carrier system might be a promising mode for controlled delivery and for improved therapeutic index of poorly water soluble RSV, as RSV-GNPs treatment showed greater antiproliferative efficacy than free RSV treatment in NCI-H460 cells.About:
This article is published in Biomedicine & Preventive Nutrition.The article was published on 2013-01-01. It has received 117 citations till now.read more
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Effective use of nanocarriers as drug delivery systems for the treatment of selected tumors.
Fakhar ud Din,Waqar Aman,Izhar Ullah,Omer Salman Qureshi,Omer Mustapha,Shumaila Shafique,Alam Zeb +6 more
TL;DR: This review increases the understanding of tumor treatment with the promising use of nanotechnology by covering the description of selected tumors, including breast, lungs, colorectal and pancreatic tumors, and applications of relative nanocarriers in these tumors.
Journal ArticleDOI
Gelatin-based nanoparticles as drug and gene delivery systems: reviewing three decades of research.
TL;DR: A general review of the different preparation techniques of gelatin nanoparticles (GNPs): desolvation, coacervation-phase separation, emulsification-solvent evaporation, reverse phase microemulsion, nanoprecipitation, self-assembly and layer-by-layer coating, from the point of view of the methodological and mechanistic aspects involved.
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Biopolymer nano-particles and natural nano-carriers for nano-encapsulation of phenolic compounds
TL;DR: Preparation, application and characterization of polymeric based nano-capsules and natural nano-carriers for phenolics, and future investigations could focus on application of phenolic nano-scale delivery systems in pharmaceuticals and functional foods.
Journal ArticleDOI
Resveratrol nanoformulations: Challenges and opportunities
TL;DR: The therapeutic potential of resveratrol is outlined, its mechanisms of action and pharmacokinetic limitations are explored, and potential techniques to improve encapsulation of the drug within nanoparticles, thereby enhancing its clinical potential are highlighted.
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Recent advancement of gelatin nanoparticles in drug and vaccine delivery.
TL;DR: The current review highlights the different formulation aspects of gelatin nanoparticles which affect the particle characteristics like zeta potential, polydispersity index, entrapment efficacy and drug release properties and gives emphasis on the major applications of collagen nanoparticles in drug and vaccine delivery, gene delivery to target tissues and nutraceutical delivery for improving the poor bioavailabity of bioactive phytonutrients.
References
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Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
TL;DR: A tetrazolium salt has been used to develop a quantitative colorimetric assay for mammalian cell survival and proliferation and is used to measure proliferative lymphokines, mitogen stimulations and complement-mediated lysis.
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A simple technique for quantitation of low levels of DNA damage in individual cells
TL;DR: Human lymphocytes were exposed to X-irradiation or treated with H2O2 and the extent of DNA migration was measured using a single-cell microgel electrophoresis technique under alkaline conditions and this technique appears to be sensitive and useful for detecting damage and repair in single cells.
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Biological effects of resveratrol.
TL;DR: Resveratrol has been shown to modulate the metabolism of lipids, and to inhibit the oxidation of low-density lipoproteins and the aggregation of platelets, and may play a role in the prevention of human cardiovascular diseases.
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Gelatin as a delivery vehicle for the controlled release of bioactive molecules.
TL;DR: This review will emphasize how biomolecules released from gelatin controlled-release systems are able to retain their biological activity, allowing for their use in tissue engineering, therapeutic angiogenesis, gene therapy, and drug delivery applications.
Journal ArticleDOI
Mechanism of tumor-targeted delivery of macromolecular drugs, including the EPR effect in solid tumor and clinical overview of the prototype polymeric drug SMANCS.
TL;DR: The general mechanism of the EPR (enhanced permeability and retention) effect and factors involved in the effect are discussed, in view of the advantages of macromolecular therapeutics for cancer treatment, which are based on the highly selective EPR-related delivery of drug to tumor.
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Gelatin-based nanoparticles as drug and gene delivery systems: reviewing three decades of research.
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