Journal ArticleDOI
Antiproliferative Action of Xylopia aethiopica Fruit Extract on Human Cervical Cancer Cells
Oluwatosin A. Adaramoye,Jayanta Sarkar,Neetu Singh,Sanjeev Meena,Bendangla Changkija,Prem P. Yadav,Sanjeev Kanojiya,Sudhir Sinha +7 more
TLDR
Results indicate that XAFE could be a potential therapeutic agent against cancer since it inhibits cell proliferation, and induces apoptosis and cell cycle arrest in C‐33A cells.Abstract:
The anticancer potential of Xylopia aethiopica fruit extract (XAFE), and the mechanism of cell death it elicits, was investigated in various cell lines. Treatment with XAFE led to a dose-dependent growth inhibition in most cell lines, with selective cytotoxicity towards cancer cells and particularly the human cervical cancer cell line C-33A. In this study, apoptosis was confirmed by nuclear fragmentation and sub-G(0)/G(1) phase accumulation. The cell cycle was arrested at the G(2)/M phase with a decreased G(0)/G(1) population. A semi-quantitative gene expression study revealed dose-dependent up-regulation of p53 and p21 genes, and an increase in the Bax/Bcl-2 ratio. These results indicate that XAFE could be a potential therapeutic agent against cancer since it inhibits cell proliferation, and induces apoptosis and cell cycle arrest in C-33A cells.read more
Citations
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A systematic review on ethnomedicines of anti-cancer plants.
Akash Tariq,Sehrish Sadia,Kaiwen Pan,Ihteram Ullah,Sakina Mussarat,Feng Sun,Olatunji Olusanya Abiodun,Olatunji Olusanya Abiodun,Altanzagas Batbaatar,Zilong Li,Dagang Song,Qinli Xiong,Riaz Ullah,Suliman Khan,Buddha Bahadur Basnet,Buddha Bahadur Basnet,Brawin Kumar,Rabiul Islam,Rabiul Islam,Muhammad Adnan +19 more
TL;DR: Results indicated that traditional medicines are mostly being use in developing countries for cancer treatment and Traditionally and scientifically skin and breast cancer types gained more focus.
Journal ArticleDOI
α -Solanine induces ROS-mediated autophagy through activation of endoplasmic reticulum stress and inhibition of Akt/mTOR pathway
Mohammad Hasanain,Ashis Bhattacharjee,Praveen Pandey,Raghib Ashraf,Nagendra Singh,Sharad Sharma,Achchhe Lal Vishwakarma,Dipak Datta,Dipak Datta,Kalyan Mitra,Kalyan Mitra,Jayanta Sarkar,Jayanta Sarkar +12 more
TL;DR: It is concluded that α-solanine induces autophagy to exert anti-proliferative activity by triggering ER stress and inhibiting Akt/mTOR signaling pathway.
Journal ArticleDOI
Potential of Central, Eastern and Western Africa Medicinal Plants for Cancer Therapy: Spotlight on Resistant Cells and Molecular Targets.
TL;DR: Plant extracts from CEWA and isolated compounds thereof exert cytotoxic effects by several modes of action including caspases activation, alteration of mitochondrial membrane potential (MMP), induction of reactive oxygen species (ROS) in cancer cells and inhibition of angiogenesis.
Journal ArticleDOI
Characterization of Keratin Microparticles from Feather Biomass with Potent Antioxidant and Anticancer Activities
Swati Sharma,Arun Gupta,Syed Mohd Saufi Bin Tuan Chik,Chua Geek Kee,Bhupendra M. Mistry,Doo Hun Kim,Gaurav Sharma +6 more
TL;DR: In the present study chicken feathers were hydrolyzed by chemical treatment in alkaline conditions and the pH value of feather hydrolyzing solution was amended accordingly the iso-electric precipitation to reveal that the extracted keratin retained the most of protein backbone.
Journal ArticleDOI
Composition and cytotoxic activity of essential oils from Xylopia aethiopica (Dunal) A. Rich, Xylopia parviflora (A. Rich) Benth.) and Monodora myristica (Gaertn) growing in Chad and Cameroon.
Issakou Bakarnga-Via,Issakou Bakarnga-Via,Jean Baptiste Hzounda,Patrick Valere Tsouh Fokou,Lauve R. Y. Tchokouaha,Magali Gary-Bobo,Audrey Gallud,Marcel Garcia,Lucain Walbadet,Youssouf Secka,Pierre Michel Jazet Dongmo,Fabrice Fekam Boyom,Chantal Menut +12 more
TL;DR: Essential oils from fruits of Monodora myristica,Xylopia aethiopica and Xylopia parviflora have shown acceptable antineoplastic potency, and might be investigated further in this regard.
References
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Journal ArticleDOI
WAF1, a potential mediator of p53 tumor suppression
Wafik S. El-Deiry,Takashi Tokino,Victor E. Velculescu,Daniel B. Levy,Ramon Parsons,Jeffrey M. Trent,D Lin,W. Edward Mercer,Kenneth W. Kinzler,Bert Vogelstein +9 more
TL;DR: A gene is identified, named WAF1, whose induction was associated with wild-type but not mutant p53 gene expression in a human brain tumor cell line and that could be an important mediator of p53-dependent tumor growth suppression.
Journal ArticleDOI
The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases
TL;DR: In this article, an improved two-hybrid system was employed to isolate human genes encoding Cdk-interacting proteins (Cips) and found that CIP1 is a potent, tight-binding inhibitor of Cdks and can inhibit the phosphorylation of Rb by cyclin A-Cdk2.
Journal ArticleDOI
On tyrosine and tryptophane determinations in proteins
Otto Folin,Vintila Ciocalteu +1 more
TL;DR: In this article, the authors summarized research into the existing methods for the quantitative determination of tyrosine and tryptophane in proteins, including the Folin-Looney method, which is based on reaction of a phosphotungstic phosphomolybdic acid in a phenol solution.
Journal ArticleDOI
Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis.
Jerry E. Chipuk,Tomomi Kuwana,Lisa Bouchier-Hayes,Nathalie Droin,Donald D. Newmeyer,Martin Schuler,Douglas R. Green +6 more
TL;DR: It is proposed that when p53 accumulates in the cytosol, it can function analogously to the BH3-only subset of proapoptotic Bcl-2proteins to activate Bax and trigger apoptosis.
Journal ArticleDOI
Movement of Bax from the Cytosol to Mitochondria during Apoptosis
TL;DR: In cells undergoing apoptosis, an early, dramatic change occurs in the intracellular localization of Bax, and this redistribution of soluble Bax to organelle-bound GFP–Bax appears important for Bx to promote cell death.
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