Journal ArticleDOI
Aortic root diameter and risk of cardiovascular events in a general population: data from the PAMELA study.
Cesare Cuspidi,Rita Facchetti,Michele Bombelli,Annalisa Re,Matteo Cairoa,Carla Sala,Marijana Tadic,Guido Grassi,Giuseppe Mancia +8 more
TLDR
The results for the first time show that ARD indexed to height is predictive of incident nonfatal and fatal cardiovascular events among middle-aged individuals in the community and support the view that assessment of ARD in addition to left ventricular mass may refine cardiovascular risk stratification and preventive strategies in the general population.Abstract:
Aim Data on the association of aortic root diameter (ARD), as assessed by echocardiography, with incident cardiovascular morbidity and mortality in the general population, are scanty and limited to elderly individuals. Thus, we investigated the value of ARD in predicting cardiovascular events in the Pressioni Arteriose Monitorate E Loro Associazioni population. Methods At entry, 1860 participants (mean age 50 ± 14, 50.6% men) underwent diagnostic tests including laboratory investigations, office and out-of-office blood pressure (BP) measurements (home and 24-h ambulatory BP monitoring), and echocardiography. ARD was measured at the level of Valsalva's sinuses and indexed to body surface area and height. Results Over a follow-up of 148 months, 137 nonfatal or fatal cardiovascular events were documented. After adjustment for age, sex, BP, fasting blood glucose, total cholesterol, smoking status, previous cardiovascular disease, and use of antihypertensive drugs, ARD/height [hazard ratio for 1 unit increase = 2.62, 95% confidence interval (CI) 1.19-5.75, P = 0.01], but not absolute ARD (hazard ratio 1.44, 95% CI 0.89-2.39, P = 0.13) neither ARD/body surface area (hazard ratio 2.09, 95% CI 0.96-4.55, P = 0.06) predicted the increased risk of cardiovascular events. The association between left ventricular hypertrophy and AR dilatation was a stronger predictor of cardiovascular prognosis than left ventricular hypertrophy alone. Conclusions Our results for the first time show that ARD indexed to height is predictive of incident nonfatal and fatal cardiovascular events among middle-aged individuals in the community and support the view that assessment of ARD in addition to left ventricular mass may refine cardiovascular risk stratification and preventive strategies in the general population.read more
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Journal Article
Alterations of Cardiac Structure in Patients With Isolated Office, Ambulatory, or Home Hypertension
RobertoSega,GiuseppeTrocino,ArturoLanzarotti,StefanoCarugo,GiancarloCesana,RiccardoSchiavina,FrancoValagussa,MicheleBombelli,CristinaGiannattasio,AlbertoZanchetti,GiuseppeMancia +10 more
TL;DR: This study studied the prevalence of isolated office hypertension and its association with echocardiographic left ventricular mass in the general population of the PAMELA Study, which involved a large, randomized sample of the Monza (Milan) population.
Journal ArticleDOI
Placental Growth Factor as an Indicator of Maternal Cardiovascular Risk After Pregnancy
Laura Benschop,Sarah Schalekamp-Timmermans,Zoe A. Broere-Brown,Jeanine E. Roeters van Lennep,Vincent W. V. Jaddoe,Jolien W. Roos-Hesselink,M. Kamran Ikram,Eric A.P. Steegers,James M. Roberts,Robin E. Gandley +9 more
TL;DR: Women with low PlGF in midpregnancy have a greater aortic root diameter, left atrial diameter, and left ventricular mass and higher systolic blood pressure 6 and 9 years after pregnancy compared to women with higher PlGF, including women with uncomplicated pregnancies.
Journal ArticleDOI
Aortic Root Dilatation Is Associated With Incident Cardiovascular Events in a Population of Treated Hypertensive Patients: The Campania Salute Network.
Grazia Canciello,Costantino Mancusi,Maria Angela Losi,Raffaele Izzo,Bruno Trimarco,Giovanni de Simone,Nicola De Luca +6 more
TL;DR: In the context of a population of treated hypertensive patients, ARD defined by z-score of predicted values is an independent predictor of CV events regardless of LVH and other common confounders.
Journal ArticleDOI
Increased Proximal Aortic Diameter is Associated With Risk of Cardiovascular Events and All-Cause Mortality in Blacks The Jackson Heart Study.
Daisuke Kamimura,Takeki Suzuki,Solomon K. Musani,Michael E. Hall,Tandaw E. Samdarshi,Adolfo Correa,Ervin R. Fox +6 more
TL;DR: Greater AoD was associated with an increased risk of cardiovascular events in a community‐based cohort of blacks, suggesting that AoD may be useful as a predictor of incident cardiovascular events.
Journal ArticleDOI
Association of Aortic Root Dilation from Early Adulthood to Middle Age with Cardiac Structure and Function: The CARDIA Study
Chike C. Nwabuo,Henrique T. Moreira,Henrique Doria de Vasconcellos,Bharath Ambale-Venkatesh,Kihei Yoneyama,Yoshiaki Ohyama,Ravi K. Sharma,Anderson C. Armstrong,Mohammed R. Ostovaneh,Cora E. Lewis,Kiang Liu,Pamela J. Schreiner,Kofo O. Ogunyankin,Samuel S. Gidding,Joao A.C. Lima +14 more
TL;DR: The hypothesis that aortic root dilation is associated with adverse cardiac remodeling is supported and the potential importance of sex‐specific ventricular‐arterial interactions in the pathogenesis of heart failure is underscored.
References
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Richard B. Devereux,N Reichek +1 more
TL;DR: The best method for LVM-E identified combined cube function geometry with a modified convention for determination of left ventricular internal dimension (LVID), posterior wall thickness (PWT), and interventricular septal thickness (IVST), which excluded the thickness of endocardial echo lines from wall thicknesses and included the thickness in LVID.
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TL;DR: This document reviews the technical aspects on how to perform quantitative chamber measurements of morphology and function, which is a component of every complete echocardiographic examination.
Journal ArticleDOI
Aortic Diameter ≥5.5 cm Is Not a Good Predictor of Type A Aortic Dissection Observations From the International Registry of Acute Aortic Dissection (IRAD)
Linda Pape,Thomas T. Tsai,Eric M. Isselbacher,Jae K. Oh,Patrick T. O'Gara,Arturo Evangelista,Rossella Fattori,Gabriel Meinhardt,Santi Trimarchi,Eduardo Bossone,Toru Suzuki,Jeanna V. Cooper,James B. Froehlich,Christoph A. Nienaber,Kim A. Eagle +14 more
TL;DR: The majority of patients with acute type A acute aortic dissection present with aorti diameters <5.5 cm and thus do not fall within current guidelines for elective aneurysm surgery, and methods other than size measurement of the ascending aorta are needed to identify patients at risk for dissection.
Journal ArticleDOI
Ambulatory blood pressure normality: results from the PAMELA study
Giuseppe Mancia,Roberto Sega,C. Bravi,G De Vito,Franco Valagussa,Giancarlo Cesana,Alberto Zanchetti +6 more
TL;DR: Data from a large and unbiased sample of a general population show that home and 24 h or daytime average blood pressures are much lower than clinic blood pressure.
Journal ArticleDOI
Aortic Diameter, Aortic Stiffness, and Wave Reflection Increase With Age and Isolated Systolic Hypertension
TL;DR: The purpose of this review is to summarize the conventional view that has evolved over decades but is not precisely argued in recent literature, that early wave reflection from peripheral arteries is the dominant ill effect of aging and the most logical target for therapy.
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