AP-1 in mouse development and tumorigenesis.
TLDR
A better molecular understanding of the cell-context dependent function of AP-1 in cell proliferation and apoptosis, in bone biology as well as in multistep tumorigenesis is obtained.Abstract:
Genetically modified mice have provided important insights into the biological functions of the dimeric transcription factor complex AP-1. Extensive analyses of mice and cells with genetically modified Fos or Jun proteins provide novel insights into the physiological functions of AP-1 proteins. Using knock-out strategies it was found that some components, such as c-Fos, FosB and JunD are dispensable, whereas others, like c-Jun, JunB and Fra-1 are essential in embryonic development and/or in the adult organism. Besides the specific roles of AP-1 proteins in developmental processes, we are beginning to obtain a better molecular understanding of the cell-context dependent function of AP-1 in cell proliferation and apoptosis, in bone biology as well as in multistep tumorigenesis.read more
Citations
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AP-1 as a regulator of cell life and death
Eitan Shaulian,Michael Karin +1 more
TL;DR: Interestingly, the growth-promoting activity of c-Jun is mediated by repression of tumour suppressors, as well as upregulation of positive cell cycle regulators, whereas JunB has the converse effect.
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Mechanisms of Hepatic Fibrogenesis
TL;DR: Clinical and translational implications of these advances have become clear, and have begun to impact significantly on the management and outlook of patients with chronic liver disease.
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Hepatic Stellate Cells: Protean, Multifunctional, and Enigmatic Cells of the Liver
TL;DR: The hepatic stellate cell has surprised and engaged physiologists, pathologists, and hepatologists for over 130 years, yet clear evidence of its role in hepatic injury and fibrosis only emerged following the refinement of methods for its isolation and characterization.
Journal ArticleDOI
AP-1: a double-edged sword in tumorigenesis
Robert Eferl,Erwin F. Wagner +1 more
TL;DR: This work focuses on the JUN and FOS proteins and aims to offer a new perspective on the molecular mechanisms that regulate the oncogenic and anti-oncogenic effects of AP-1 in tumour development.
Journal ArticleDOI
Transcriptional regulation by calcium, calcineurin, and NFAT
TL;DR: The NFAT family of transcription factors encompasses five proteins evolutionarily related to the Rel/NF B family, and it is clear that NFAT activates transcription of a large number of genes during an effective immune response.
References
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TL;DR: This work has been supported by the Department of the Army and the National Institutes of Health, and the author acknowledges the support and encouragement of the National Cancer Institute.
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Peter Angel,Michael Karin +1 more
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Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene
Derek D. Yang,Chia-Yi Kuan,Alan J. Whitmarsh,Alan J. Whitmarsh,Mercedes Rincon,Timothy S. Zheng,Roger J. Davis,Roger J. Davis,Pasko Rakic,Richard A. Flavell +9 more
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Journal ArticleDOI
c-Fos: a Key Regulator of Osteoclast-Macrophage Lineage Determination and Bone Remodeling
Agamemnon E. Grigoriadis,Zhao-Qi Wang,Marco G. Cecchini,Willy Hofstetter,Rolf Felix,Herbert Fleisch,Erwin F. Wagner +6 more
TL;DR: Results identify Fos as a key regulator of osteoclast-macrophage lineage determination in vivo and provide insights into the molecular mechanisms underlying metabolic bone diseases.