Association of serum HDL-cholesterol and apolipoprotein A1 levels with risk of severe SARS-CoV-2 infection.
James R. Hilser,Yi Han,Subarna Biswas,Janet Gukasyan,Zhiheng Cai,Ruowei Zhu,W.H. Wilson Tang,W.H. Wilson Tang,Arjun Deb,Aldons J. Lusis,Jaana Hartiala,Hooman Allayee +11 more
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In this article, the relationship between severity of COVID-19 and metabolic syndrome-related serum biomarkers measured prior to SARS-CoV-2 infection was investigated using data from the UK Biobank.About:
This article is published in Journal of Lipid Research.The article was published on 2021-03-02 and is currently open access. It has received 41 citations till now. The article focuses on the topics: Apolipoprotein B & Apolipoprotein A1.read more
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Atherosclerosis: Recent developments
Johan Björkegren,Aldons J. Lusis +1 more
TL;DR: A review of the current understanding of the molecular, cellular, genetic, and environmental contributions to atherosclerosis, from both individual pathway and systems perspectives, can be found in this paper .
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Incomplete Systemic Recovery and Metabolic Phenoreversion in Post-Acute-Phase Nonhospitalized COVID-19 Patients: Implications for Assessment of Post-Acute COVID-19 Syndrome.
Elaine Holmes,Elaine Holmes,Julien Wist,Julien Wist,Reika Masuda,Samantha Lodge,Philipp Nitschke,Torben Kimhofer,Ruey Leng Loo,Sofina Begum,Berin A. Boughton,Rongchang Yang,Aude-Claire Morillon,Sung Tong Chin,Drew Hall,Monique Ryan,Sze-How Bong,Dale W. Edgar,Dale W. Edgar,John C. Lindon,Toby Richards,Bu B. Yeap,Sven Pettersson,Sven Pettersson,Manfred Spraul,Hartmut Schaefer,Nathan G. Lawler,Nicola Gray,Luke Whiley,Jeremy K. Nicholson,Jeremy K. Nicholson +30 more
TL;DR: In this paper, a multivariate metabotyping approach was used to assess the functional recovery of non-hospitalized COVID-19 patients and the possible biochemical sequelae of "Post-Acute CoV-19 Syndrome", colloquially known as long-COVID.
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Metabolic Reprogramming in COVID-19.
Tao Shen,Tingting Wang +1 more
TL;DR: In this article, a review of metabolic reprogramming in COVID-19 infection is presented, and the possibility of targeting reprogrammed metabolism to combat virus infection is discussed.
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Identifying factors contributing to increased susceptibility to COVID-19 risk: a systematic review of Mendelian randomization studies
TL;DR: Modifiable factors for intervention (e.g. smoking, obesity and inflammatory factors) and proteomic signatures that could help identify drugs for treating COVID-19 are summarized.
References
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TL;DR: Human airway epithelial cells were used to isolate a novel coronavirus, named 2019-nCoV, which formed a clade within the subgenus sarbecovirus, Orthocoronavirinae subfamily, which is the seventh member of the family of coronaviruses that infect humans.
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Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families
Elizabeth H. Corder,Ann M. Saunders,Warren J. Strittmatter,Donald E. Schmechel,P. C. Gaskell,Gary W. Small,A. D. Roses,Jonathan L. Haines,Margaret A. Pericak-Vance +8 more
TL;DR: The APOE-epsilon 4 allele is associated with the common late onset familial and sporadic forms of Alzheimer9s disease (AD) in 42 families with late onset AD.
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An interactive web-based dashboard to track COVID-19 in real time.
TL;DR: The outbreak of the 2019 novel coronavirus disease (COVID-19) has induced a considerable degree of fear, emotional stress and anxiety among individuals around the world.
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Second-generation PLINK: rising to the challenge of larger and richer datasets
Christopher C. Chang,Carson C. Chow,Laurent C. A. M. Tellier,Shashaank Vattikuti,Shaun Purcell,James J. Lee +5 more
TL;DR: The second-generation versions of PLINK will offer dramatic improvements in performance and compatibility, and for the first time, users without access to high-end computing resources can perform several essential analyses of the feature-rich and very large genetic datasets coming into use.