B cell receptor signaling in chronic lymphocytic leukemia.
Jan A. Burger,Nicholas Chiorazzi +1 more
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TLDR
The evolution of this field is discussed, from BCR-related prognostic markers, to mechanisms of BCR activation, and targeting of B CR-associated kinases, the emerging Achilles' heel in CLL pathogenesis.About:
This article is published in Trends in Immunology.The article was published on 2013-12-01 and is currently open access. It has received 378 citations till now. The article focuses on the topics: B-cell receptor & Chronic lymphocytic leukemia.read more
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Journal ArticleDOI
Cytogenetics in Chronic Lymphocytic Leukemia: ERIC Perspectives and Recommendations
Panagiotis Baliakas,Blanca Espinet,Clemens Mellink,Marie Jarošová,Anastasia Athanasiadou,Paolo Ghia,Arnon P. Kater,David Oscier,Claudia Haferlach,Kostas Stamatopoulos +9 more
TL;DR: Cytogenetic analysis is not yet mature enough to guide treatment choices in CLL, and ERIC encourages the wide application of CBA, and potentially also CMA, in clinical trials in order to obtain robust evidence regarding the predictive value of specific cytogenetic profiles towards refining risk stratification and improving the management of patients with CLL.
Journal ArticleDOI
Non-Coding RNAs as Cancer Hallmarks in Chronic Lymphocytic Leukemia.
TL;DR: This review will focus on the most important short and long non-coding RNAs in chronic lymphocytic leukemia (CLL), highlighting their implications as potential biomarkers and therapeutic targets as they relate to the well-established hallmarks of cancer.
Journal ArticleDOI
Lipoprotein lipase in chronic lymphocytic leukemia: function and prognostic implications
TL;DR: Current knowledge on the prognostic and biological relevance of LPL in CLL is reviewed, finding that LPL exerts a central role in overall lipid metabolism and transport, but plays additional, non‐catalytic roles as well.
Journal ArticleDOI
Novel role of prostate apoptosis response-4 tumor suppressor in B-cell chronic lymphocytic leukemia
Mary K. McKenna,Sunil K. Noothi,Sunil K. Noothi,Sara S. Alhakeem,Karine Z. Oben,Joseph T. Greene,Rajeswaran Mani,Kathryn L. Perry,James P. Collard,Jacqueline R. Rivas,Gerhard C. Hildebrandt,Gerhard C. Hildebrandt,Roger A. Fleischman,Roger A. Fleischman,Eric B. Durbin,John C. Byrd,Chi Wang,Natarajan Muthusamy,Vivek M. Rangnekar,Vivek M. Rangnekar,Subbarao Bondada +20 more
TL;DR: It is found that chronic lymphocytic leukemia (CLL) cells from human patients and from Eµ-Tcl1 mice constitutively express Par-4 in greater amounts than normal B-1 or B-2 cells.
Journal ArticleDOI
Calreticulin as a novel B-cell receptor antigen in chronic lymphocytic leukemia.
Elisa Ten Hacken,Maria Gounari,Jaap Willem Back,Ekaterina Shimanovskaya,Lydia Scarfò,Ekaterina Kim,Jared K. Burks,Maurilio Ponzoni,Giuseppe A. Ramirez,William G. Wierda,Zeev Estrov,Michael J. Keating,Alessandra Ferrajoli,Kostas Stamatopoulos,Paolo Ghia,Jan A. Burger +15 more
TL;DR: The mutational status of the immunoglobulin heavy chain variable region (IGHV) genes of the BCR, which distinguishes patients with mutated IGHV from those with unmutated I GHV (M-CLL or U-C LL, with ≥ 2% deviation or <2% deviation from the germline sequence, respectively), is associated with BCR signaling capacity and major differences in disease progression.
References
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Journal ArticleDOI
Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia.
Terry J. Hamblin,Zadie Davis,Zadie Davis,Anne Gardiner,Anne Gardiner,David G. Oscier,David G. Oscier,Freda K. Stevenson,Freda K. Stevenson +8 more
TL;DR: In this paper, the authors sequenced the Ig V(H) genes of the tumor cells of 84 patients with CLL and correlated their findings with clinical features, finding that the lack of somatic mutation and trisomy 12 was associated with a less favorable prognosis.
Journal ArticleDOI
Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia.
Rajendra N. Damle,Tarun Wasil,Tarun Wasil,Tarun Wasil,Franco Fais,Franco Fais,Franco Fais,Fabio Ghiotto,Fabio Ghiotto,Fabio Ghiotto,Angelo Valetto,Angelo Valetto,Angelo Valetto,Steven L. Allen,Steven L. Allen,Steven L. Allen,Aby Buchbinder,Aby Buchbinder,Aby Buchbinder,Daniel R. Budman,Daniel R. Budman,Daniel R. Budman,Klaus Dittmar,Klaus Dittmar,Klaus Dittmar,Jonathan E. Kolitz,Jonathan E. Kolitz,Jonathan E. Kolitz,Stuart M. Lichtman,Stuart M. Lichtman,Stuart M. Lichtman,Philip Schulman,Philip Schulman,Philip Schulman,Vincent Vinciguerra,Vincent Vinciguerra,Vincent Vinciguerra,Kanti R. Rai,Kanti R. Rai,Kanti R. Rai,Manlio Ferrarini,Manlio Ferrarini,Manlio Ferrarini,Nicholas Chiorazzi,Nicholas Chiorazzi,Nicholas Chiorazzi +45 more
TL;DR: In this paper, cellular immunophenotypic studies were performed on a cohort of randomly selected IgM(+) B-chronic lymphocytic leukemia (B-CLL) cases for which Ig V(H) and V(L) gene sequences were available.
Journal ArticleDOI
Targeting BTK with Ibrutinib in Relapsed Chronic Lymphocytic Leukemia
John C. Byrd,Richard R. Furman,Steven Coutre,Ian W. Flinn,Jan A. Burger,Kristie A. Blum,Barbara Grant,Jeff P. Sharman,Morton Coleman,William G. Wierda,Jeffrey A. Jones,Weiqiang Zhao,Nyla A. Heerema,Amy J. Johnson,Juthamas Sukbuntherng,Betty Y. Chang,Fong Clow,Eric Hedrick,Joseph J. Buggy,Danelle F. James,Susan O'Brien +20 more
TL;DR: Ibrutinib was associated with a high frequency of durable remissions in patients with relapsed or refractory CLL and small lymphocytic lymphoma, including patients with high-risk genetic lesions.
Journal ArticleDOI
Chronic lymphocytic leukemia.
TL;DR: From the Institute for Medical Research, North Shore–LIJ Health System (N.R.R.), and the Departments of Medicine, North shore University Hospital, Manhasset, N.Y. (K.C., K.R.) and the Dipartimento di Oncologia Clinica e Sperimentale, Universitá di Genova (M.F.).
Journal ArticleDOI
Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma
R. Eric Davis,Vu N. Ngo,Georg Lenz,Pavel Tolar,Ryan M. Young,Paul B. Romesser,Holger Kohlhammer,Laurence Lamy,Hong Zhao,Yandan Yang,Weihong Xu,Arthur L. Shaffer,George E. Wright,Wenming Xiao,John Powell,Jian Kang Jiang,Craig J. Thomas,Andreas Rosenwald,German Ott,Hans K. Müller-Hermelink,Randy D. Gascoyne,Joseph M. Connors,Nathalie A. Johnson,Lisa M. Rimsza,Elias Campo,Elaine S. Jaffe,Wyndham H. Wilson,Jan Delabie,Erlend B. Smeland,Richard I. Fisher,Rita M. Braziel,Raymond R. Tubbs,James R. Cook,Dennis D. Weisenburger,Wing C. Chan,Susan K. Pierce,Louis M. Staudt +36 more
TL;DR: Findings establish chronic active BCR signalling as a new pathogenetic mechanism in ABC DLBCL, suggesting several therapeutic strategies.
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