Betaglycan presents ligand to the TGFβ signaling receptor
TLDR
Transforming growth factor β signals through a heteromeric protein kinase receptor that has a limited ability to bind ligand is overcome by the action of betaglycan (TGFβ type III receptor), a separate TGFβ-binding membrane protein of previously unknown function.About:
This article is published in Cell.The article was published on 1993-07-02 and is currently open access. It has received 888 citations till now. The article focuses on the topics: Transforming growth factor & Cell surface receptor.read more
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TGF-beta signal transduction.
TL;DR: The transforming growth factor beta (TGF-beta) family of growth factors control the development and homeostasis of most tissues in metazoan organisms and mutations in these pathways are the cause of various forms of human cancer and developmental disorders.
Journal ArticleDOI
TGFβ signalling in context.
TL;DR: The basic elements of the transforming growth factor-β (TGFβ) pathway were revealed and the concept of how the TGFβ signal travels from the membrane to the nucleus has been enriched with additional findings.
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Neuropilin-1 Is Expressed by Endothelial and Tumor Cells as an Isoform-Specific Receptor for Vascular Endothelial Growth Factor
TL;DR: It is proposed that neuropilin-1 is a novel V EGF receptor that modulates VEGF binding to KDR and subsequent bioactivity and therefore may regulate VEGf-induced angiogenesis.
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Inactivation of the Type II TGF-β Receptor in Colon Cancer Cells with Microsatellite Instability
Sanford D. Markowitz,Jing Wang,Lois Myeroff,Ramon Parsons,Lu Zhe Sun,James Lutterbaugh,Robert S. Fan,Elizabeth Zborowska,Kenneth W. Kinzler,Bert Vogelstein,Bert Vogelstein,Michael G. Brattain,James K V Willson +12 more
TL;DR: Human colon cancer cell lines with high rates of microsatellite instability were found to harbor mutations in the type II TGF-beta receptor (RII) gene, which links DNA repair defects with a specific pathway of tumor progression.
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Tgfbeta signaling in growth control, cancer, and heritable disorders
TL;DR: The author would like to thank S. H. Roan for all her help and members of the Massague laboratory for insightful discussions.
References
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Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product.
TL;DR: In this article, six monoclonal antibodies have been isolated from mice immunized with synthetic peptide immunogens whose sequences are derived from that of the human c-myc gene product.
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Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor.
TL;DR: It is demonstrated that free heparin and heparan sulfate can reconstitute a low affinity receptor that is, in turn, required for the high affinity binding of bFGF.
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Requirement of heparan sulfate for bFGF-mediated fibroblast growth and myoblast differentiation.
TL;DR: Prevention of binding between cell surface heparan sulfate and bFGF substantially reduces binding of fibroblast growth factor to its cell-surface receptors, blocks the ability of bF GF to support the growth of Swiss 3T3 fibroblasts, and induces terminal differentiation of MM14 skeletal muscle cells, which is normally repressed by fibro Blast growth factor.