Journal ArticleDOI
Brucine, an effective natural compound derived from nux-vomica, induces G1 phase arrest and apoptosis in LoVo cells.
TLDR
Brucine is effective against Lo Vo cells proliferation, and promotes LoVo cells death via apoptosis, which reveals functional interplay among a series of pathway that are deregulated in cancer and suggest that their simultaneous targeting by Brucine could result in efficacious inhibition on cancer cells.About:
This article is published in Food and Chemical Toxicology.The article was published on 2013-08-01. It has received 36 citations till now. The article focuses on the topics: Brucine & Cell cycle.read more
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Journal ArticleDOI
Emerging Cytotoxic Alkaloids in the Battle against Cancer: Overview of Molecular Mechanisms.
TL;DR: A review of the literature on some of the promising anticancer alkaloids that have not been well discussed previously to provide a better understanding of the anticancer mechanisms of these promising natural products that are a rich reservoir for drug discovery.
Journal ArticleDOI
Botany, Phytochemistry, Pharmacology and Toxicity of Strychnos nux-vomica L.: A Review.
Rixin Guo,Ting Wang,Guohong Zhou,Meng-Ying Xu,Meng-Ying Xu,Xiankuo Yu,Xiao Zhang,Xiao Zhang,Feng Sui,Chun Li,Liying Tang,Zhuju Wang +11 more
TL;DR: This study provides a relevant and comprehensive review of S. nux-vomica L., including its botany, ethnopharmacology, phytochemistry, pharmacology and toxicology, thus providing a foundation for future studies and exploring the detoxification mechanism associated with processing more deeply.
Journal ArticleDOI
Induction of apoptosis in human leukemia cells through an intrinsic pathway by cathachunine, a unique alkaloid isolated from Catharanthus roseus.
Xiaodong Wang,Chenyang Li,Miaomiao Jiang,Dong Li,Ping Wen,Xun Song,Jun-Da Chen,Li-Xuan Guo,Xiaopeng Hu,Guo-Qiang Li,Jian Zhang,Chunhua Wang,Zhendan He +12 more
TL;DR: An unprecedented bisindole alkaloid cathachunine which lost C-18' and C-19' was isolated from C. roseus exerted a potent antitumor effect toward human leukemia cells through the induction of apoptosis via an intrinsic pathway, providing evidence for a new lead compound from a natural source for anti-cancer investigations.
Journal ArticleDOI
Brucine: A Review of Phytochemistry, Pharmacology, and Toxicology.
TL;DR: The physicochemical properties, pharmacological activities, and toxicity of brucine were reviewed, and the novel strategies to address the toxicity issues were discussed, aiming to bring new insights into further research and application of this active component.
Journal ArticleDOI
Brucine, an alkaloid from seeds of Strychnos nux-vomica Linn., represses hepatocellular carcinoma cell migration and metastasis: The role of hypoxia inducible factor 1 pathway
TL;DR: It is demonstrated that brucine dramatically repressed HepG2 and SMMC-7721 HCC cell migration with few cytotoxic effects and the inhibition of the HIF-1 pathway is implicated in the anti-metastasis activity of brucines.
References
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Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis
TL;DR: The effects of dominant-interfering or constitutively activated forms of various components of the JNK-p38 and ERK signaling pathways demonstrated that activation of JNK and p38 and concurrent inhibition of ERK are critical for induction of apoptosis in these cells.
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BCL-2 family members and the mitochondria in apoptosis
TL;DR: As the BCL-2 family members reside upstream of irreversible cellular damage and focus much of their efforts at the level of mitochondria, they play a pivotal role in deciding whether a cell will live or die, and it is argued that the amphipathic a-helical BH3 domain serves as a critical death domain in the pro-apoptotic members.
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Principles of CDK regulation
TL;DR: The activity of cyclin-dependent kinases is controlled by four highly conserved biochemical mechanisms, forming a web of regulatory pathways unmatched in its elegance and intricacy.
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Plants as a source of anti-cancer agents.
Gordon M. Cragg,David J. Newman +1 more
TL;DR: A number of promising new agents are in clinical development based on selective activity against cancer-related molecular targets, including flavopiridol and combretastin A4 phosphate, while some agents which failed in earlier clinical studies are stimulating renewed interest.
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Natural products for cancer prevention: a global perspective
TL;DR: This review focuses on the many natural products that have been implicated in cancer prevention and that promote human health without recognisable side effects from vegetables, fruits, plant extracts, and herbs.