Cancer statistics, 2016
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TLDR
Overall cancer incidence trends are stable in women, but declining by 3.1% per year in men, much of which is because of recent rapid declines in prostate cancer diagnoses, and brain cancer has surpassed leukemia as the leading cause of cancer death among children and adolescents.Abstract:
Each year, the American Cancer Society estimates the numbers of new cancer cases and deaths that will occur in the United States in the current year and compiles the most recent data on cancer incidence, mortality, and survival. Incidence data were collected by the National Cancer Institute (Surveillance, Epidemiology, and End Results [SEER] Program), the Centers for Disease Control and Prevention (National Program of Cancer Registries), and the North American Association of Central Cancer Registries. Mortality data were collected by the National Center for Health Statistics. In 2016, 1,685,210 new cancer cases and 595,690 cancer deaths are projected to occur in the United States. Overall cancer incidence trends (13 oldest SEER registries) are stable in women, but declining by 3.1% per year in men (from 2009-2012), much of which is because of recent rapid declines in prostate cancer diagnoses. The cancer death rate has dropped by 23% since 1991, translating to more than 1.7 million deaths averted through 2012. Despite this progress, death rates are increasing for cancers of the liver, pancreas, and uterine corpus, and cancer is now the leading cause of death in 21 states, primarily due to exceptionally large reductions in death from heart disease. Among children and adolescents (aged birth-19 years), brain cancer has surpassed leukemia as the leading cause of cancer death because of the dramatic therapeutic advances against leukemia. Accelerating progress against cancer requires both increased national investment in cancer research and the application of existing cancer control knowledge across all segments of the population.read more
Citations
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Journal ArticleDOI
Molecular characterization of breast cancer CTCs associated with brain metastasis
Debasish Boral,Monika Vishnoi,Haowen N. Liu,Wei Yin,Marc L. Sprouse,Antonio Scamardo,David S. Hong,Tuan Zea Tan,Jean P. Thiery,Jenny C. Chang,Dario Marchetti +10 more
TL;DR: It is reported that BCBM CTCs is enriched in a distinct sub-population of cells identifiable by their biomarker expression and mutational content, which may allow for early diagnosis of brain metastasis and/or help for treatment choice and its efficacy.
Journal ArticleDOI
IL-6 and ovarian cancer: inflammatory cytokines in promotion of metastasis.
TL;DR: Understanding the important role of IL-6 and its family members’ effects on the pathogenesis of ovarian cancer tumor growth and metastasis may lead to more novel treatments, detection methods, and improvement of overall clinical outcomes.
Journal ArticleDOI
“Smart” materials-based near-infrared light-responsive drug delivery systems for cancer treatment: A review
TL;DR: There are three types of NIR-responsive drug delivery systems (NIRDDSs) based on the mechanism, i.e., photothermal effect, two-photon absorption, and up-converting nanoparticles (UCNPs) as mentioned in this paper.
Book ChapterDOI
Breast Cancer Statistics: Recent Trends.
TL;DR: The incidence rate of breast cancer in the US is clearly on rise, which is indicative of aggressive screenings and detections, and more efforts are needed to improve the prognosis of patients diagnosed at a later stage.
Journal ArticleDOI
Response to anti-PD1 therapy with nivolumab in metastatic sarcomas
Luca Paoluzzi,A. Cacavio,Munir Ghesani,A. Karambelkar,Amy Rapkiewicz,Jeffrey S. Weber,Gerald Rosen +6 more
TL;DR: In this article, the authors retrospectively analyzed a cohort of patients with relapsed metastatic/unresectable sarcomas, who were treated with nivolumab provided under a patient assistance program from the manufacturer.
References
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Permutation tests for joinpoint regression with applications to cancer rates
TL;DR: A joinpoint regression model is applied to describe continuous changes in the recent trend and the grid-search method is used to fit the regression function with unknown joinpoints assuming constant variance and uncorrelated errors.
Book
International Classification of Diseases for Oncology
TL;DR: This list of diseases for oncology includes cancers of the central nervous system, as well as other types of diseases such as lymphoma, leukaemia, and so on.