Cancer statistics, 2016
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TLDR
Overall cancer incidence trends are stable in women, but declining by 3.1% per year in men, much of which is because of recent rapid declines in prostate cancer diagnoses, and brain cancer has surpassed leukemia as the leading cause of cancer death among children and adolescents.Abstract:
Each year, the American Cancer Society estimates the numbers of new cancer cases and deaths that will occur in the United States in the current year and compiles the most recent data on cancer incidence, mortality, and survival. Incidence data were collected by the National Cancer Institute (Surveillance, Epidemiology, and End Results [SEER] Program), the Centers for Disease Control and Prevention (National Program of Cancer Registries), and the North American Association of Central Cancer Registries. Mortality data were collected by the National Center for Health Statistics. In 2016, 1,685,210 new cancer cases and 595,690 cancer deaths are projected to occur in the United States. Overall cancer incidence trends (13 oldest SEER registries) are stable in women, but declining by 3.1% per year in men (from 2009-2012), much of which is because of recent rapid declines in prostate cancer diagnoses. The cancer death rate has dropped by 23% since 1991, translating to more than 1.7 million deaths averted through 2012. Despite this progress, death rates are increasing for cancers of the liver, pancreas, and uterine corpus, and cancer is now the leading cause of death in 21 states, primarily due to exceptionally large reductions in death from heart disease. Among children and adolescents (aged birth-19 years), brain cancer has surpassed leukemia as the leading cause of cancer death because of the dramatic therapeutic advances against leukemia. Accelerating progress against cancer requires both increased national investment in cancer research and the application of existing cancer control knowledge across all segments of the population.read more
Citations
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Hepatocellular Carcinoma Detection by Plasma Methylated DNA: Discovery, Phase I Pilot, and Phase II Clinical Validation
John B. Kisiel,Brian A. Dukek,Reddappa V.S.R. Kanipakam,Hassan Ghoz,Tracy C. Yab,Calise K. Berger,William R. Taylor,Patrick H. Foote,Nasra H. Giama,Kristeen Onyirioha,Mohamed A. Abdallah,Kelli N. Burger,Seth W. Slettedahl,Douglas W. Mahoney,Thomas C. Smyrk,Jason T. Lewis,Maria Giakoumopoulos,Hatim T. Allawi,Graham P. Lidgard,Lewis R. Roberts,David A. Ahlquist +20 more
TL;DR: MDMs identified in this study proved to accurately detect HCC by plasma testing using target enrichment long‐probe quantitative amplified signal (TELQAS) assays.
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Epidemiology of Brain Tumors
TL;DR: Analysis of large, multicenter, epidemiologic studies, as well as well annotated omic datasets can potentially lead to further understanding of the relationship between gene and environment in the process of brain tumor development.
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Immune checkpoint inhibitors in advanced renal cell carcinoma: experience to date and future directions
TL;DR: Current evidence related to the clinical use of checkpoint inhibitors for the treatment of patients with aRCC is discussed, including information on the frequency and management of unconventional responses and the management of immune-related adverse events.
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Survival Rates After Lobectomy, Segmentectomy, and Wedge Resection for Non-Small Cell Lung Cancer
TL;DR: Although the OS rate was better for lobectomy than for wedge resection, no statistical differences in the LCSS rate were identified among the three treatment groups of patients with tumors that were 1.0 cm or smaller.
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Injectable polypeptide hydrogel for dual-delivery of antigen and TLR3 agonist to modulate dendritic cells in vivo and enhance potent cytotoxic T-lymphocyte response against melanoma
Huijuan Song,Pingsheng Huang,Jinfeng Niu,Gaona Shi,Chuangnian Zhang,Deling Kong,Deling Kong,Deling Kong,Weiwei Wang +8 more
TL;DR: Hydrogel as the delivery system significantly improves antigen persistence at the injection site and antigen drainage to lymph nodes, and implies that such a hydrogel may serve as a multifunctional delivery platform of vaccines.
References
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Book
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TL;DR: This list of diseases for oncology includes cancers of the central nervous system, as well as other types of diseases such as lymphoma, leukaemia, and so on.