Cancer statistics, 2016
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TLDR
Overall cancer incidence trends are stable in women, but declining by 3.1% per year in men, much of which is because of recent rapid declines in prostate cancer diagnoses, and brain cancer has surpassed leukemia as the leading cause of cancer death among children and adolescents.Abstract:
Each year, the American Cancer Society estimates the numbers of new cancer cases and deaths that will occur in the United States in the current year and compiles the most recent data on cancer incidence, mortality, and survival. Incidence data were collected by the National Cancer Institute (Surveillance, Epidemiology, and End Results [SEER] Program), the Centers for Disease Control and Prevention (National Program of Cancer Registries), and the North American Association of Central Cancer Registries. Mortality data were collected by the National Center for Health Statistics. In 2016, 1,685,210 new cancer cases and 595,690 cancer deaths are projected to occur in the United States. Overall cancer incidence trends (13 oldest SEER registries) are stable in women, but declining by 3.1% per year in men (from 2009-2012), much of which is because of recent rapid declines in prostate cancer diagnoses. The cancer death rate has dropped by 23% since 1991, translating to more than 1.7 million deaths averted through 2012. Despite this progress, death rates are increasing for cancers of the liver, pancreas, and uterine corpus, and cancer is now the leading cause of death in 21 states, primarily due to exceptionally large reductions in death from heart disease. Among children and adolescents (aged birth-19 years), brain cancer has surpassed leukemia as the leading cause of cancer death because of the dramatic therapeutic advances against leukemia. Accelerating progress against cancer requires both increased national investment in cancer research and the application of existing cancer control knowledge across all segments of the population.read more
Citations
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Journal ArticleDOI
Oncogenic Kras drives invasion and maintains metastases in colorectal cancer
Adam T. Boutin,Wen Ting Liao,Melody Wang,Soyoon Sarah Hwang,Tatiana Karpinets,Hannah Cheung,Gerald C. Chu,Shan Jiang,Jian Hu,Kyle Chang,Eduardo Vilar,Xingzhi Song,Jianhua Zhang,Scott Kopetz,Andrew Futreal,Y. Alan Wang,Lawrence N. Kwong,Ronald A. DePinho +17 more
TL;DR: A mouse model of metastatic CRC that harbors an inducible oncogenic Kras allele (Krasmut ) and conditional null alleles of Apc and Trp53 (iKAP) provides genetic evidence that Krasmut drives CRC invasion and maintenance of metastases.
Proceedings ArticleDOI
Capsule Networks for Brain Tumor Classification Based on MRI Images and Coarse Tumor Boundaries
TL;DR: In this article, a modified CapsNet architecture is proposed for brain tumor classification, which takes the tumor coarse boundaries as extra inputs within its pipeline to increase the CapsNet's focus.
Journal ArticleDOI
Role of the dynamic tumor microenvironment in controversies regarding immune checkpoint inhibitors for the treatment of non-small cell lung cancer (NSCLC) with EGFR mutations
TL;DR: A review of the currently controversial topic of PD-L1 axis inhibitors in patients with NSCLC whose tumors harbor EGFR mutations in an attempt to aid in the decision-making process.
Journal ArticleDOI
Circulating Tumor Cell Count Correlates with Colorectal Neoplasm Progression and Is a Prognostic Marker for Distant Metastasis in Non-Metastatic Patients.
Wen-Sy Tsai,Jinn-Shiun Chen,Hung-Jen Shao,Jen-chia Wu,Jr-Ming Lai,Si-Hong Lu,Si-Hong Lu,Tsung-Fu Hung,Yen-Chi Chiu,Jeng-Fu You,Pao-Shiu Hsieh,Chien-Yuh Yeh,Hsin-Yuan Hung,Sum-Fu Chiang,Geng-Ping Lin,Reiping Tang,Ying-Chih Chang,Ying-Chih Chang +17 more
TL;DR: By employing a sensitive device, CTC counts show good correlation with colorectal neoplasm, thus CTC may be as a simple, independent prognostic marker for the non-metastatic CRC patients who are at high risk of early recurrence.
Journal ArticleDOI
The Role of Gut Microbiome in the Pathogenesis of Prostate Cancer: A Prospective, Pilot Study.
David M. Golombos,Abimbola Ayangbesan,Padraic O'Malley,Patrick Lewicki,LaMont Barlow,Christopher E. Barbieri,Chrystal Chan,Casey DuLong,Galeb Abu-Ali,Curtis Huttenhower,Douglas S. Scherr +10 more
TL;DR: Biologically significant differences exist in the gut microbial composition of men with prostate cancer compared to benign controls, and these differences may play a role in the pathobiology of prostate cancer, and warrant further exploration.
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