Cancer statistics, 2016
Reads0
Chats0
TLDR
Overall cancer incidence trends are stable in women, but declining by 3.1% per year in men, much of which is because of recent rapid declines in prostate cancer diagnoses, and brain cancer has surpassed leukemia as the leading cause of cancer death among children and adolescents.Abstract:
Each year, the American Cancer Society estimates the numbers of new cancer cases and deaths that will occur in the United States in the current year and compiles the most recent data on cancer incidence, mortality, and survival. Incidence data were collected by the National Cancer Institute (Surveillance, Epidemiology, and End Results [SEER] Program), the Centers for Disease Control and Prevention (National Program of Cancer Registries), and the North American Association of Central Cancer Registries. Mortality data were collected by the National Center for Health Statistics. In 2016, 1,685,210 new cancer cases and 595,690 cancer deaths are projected to occur in the United States. Overall cancer incidence trends (13 oldest SEER registries) are stable in women, but declining by 3.1% per year in men (from 2009-2012), much of which is because of recent rapid declines in prostate cancer diagnoses. The cancer death rate has dropped by 23% since 1991, translating to more than 1.7 million deaths averted through 2012. Despite this progress, death rates are increasing for cancers of the liver, pancreas, and uterine corpus, and cancer is now the leading cause of death in 21 states, primarily due to exceptionally large reductions in death from heart disease. Among children and adolescents (aged birth-19 years), brain cancer has surpassed leukemia as the leading cause of cancer death because of the dramatic therapeutic advances against leukemia. Accelerating progress against cancer requires both increased national investment in cancer research and the application of existing cancer control knowledge across all segments of the population.read more
Citations
More filters
Journal ArticleDOI
Comparative genomic analysis of esophageal squamous cell carcinoma between Asian and Caucasian patient populations
Jiaying Deng,Hu Chen,Hu Chen,Daizhan Zhou,Junhua Zhang,Yun Chen,Qi Liu,Dashan Ai,Hanting Zhu,Li Chu,Wenjia Ren,Xiaofei Zhang,Yi Xia,Menghong Sun,H. Zhang,Jun Li,Xinxin Peng,Liang Li,Leng Han,Hui Lin,Xiujun Cai,Jiaqing Xiang,Shufeng Chen,Yihua Sun,Yawei Zhang,Jie Zhang,Haiquan Chen,Shijian Zhang,Yi Zhao,Yun Liu,Han Liang,Han Liang,Kuaile Zhao +32 more
TL;DR: Analysis of Chinese and TCGA ESCC patients reveals that Asian patients exhibit higher TP53, EP300 and NFE2L2 mutational frequencies, and mutated CSMD3 associates with better prognosis, and represents a general computational framework for cross-population comparison.
Journal ArticleDOI
Plumbagin inhibits the proliferation and survival of esophageal cancer cells by blocking STAT3-PLK1-AKT signaling.
Ying-Ya Cao,Jing Yu,Ting-Ting Liu,Kai-Xia Yang,Li-Yan Yang,Qun Chen,Feng Shi,Jia-Jie Hao,Yan Cai,Ming-Rong Wang,Weihua Lu,Yu Zhang +11 more
TL;DR: It is found that treatment with plumbagin reduced proliferation and survival of the KYSE150 and KYSE450 ESCC cell lines in a dose-dependent manner in vitro and in vivo, and inhibited the viability of primary ESCC cells from fresh biopsy specimens.
Journal ArticleDOI
Phase 1 trial evaluating cisplatin, gemcitabine, and veliparib in 2 patient cohorts: Germline BRCA mutation carriers and wild-type BRCA pancreatic ductal adenocarcinoma.
Eileen M. O'Reilly,Eileen M. O'Reilly,Jonathan W. Lee,Maeve A. Lowery,Marinela Capanu,Zsofia K. Stadler,Zsofia K. Stadler,Malcolm J. Moore,Neesha C. Dhani,Hedy L. Kindler,Hayley Estrella,Hannah Maynard,Talia Golan,Amiel Segal,Erin E. Salo-Mullen,Kenneth H. Yu,Kenneth H. Yu,Andrew S. Epstein,Andrew S. Epstein,Michal Segal,Robin Brenner,Richard K. G. Do,Richard K. G. Do,Alice P. Chen,Laura H. Tang,Laura H. Tang,David P. Kelsen,David P. Kelsen +27 more
TL;DR: The aims were to determine the safety, dose‐limiting toxicities (DLTs), maximum tolerated dose, and recommended phase 2 dose (RP2D) of veliparib combined with cisplatin and gemcitabine and to assess the antitumor efficacy and overall survival.
Journal ArticleDOI
Blockade of TIM3 relieves immunosuppression through reducing regulatory T cells in head and neck cancer
TL;DR: The present study demonstrated that TIM3 was associated with the immunosuppression in HNSCC and targeting TIM3 can enhance anti-tumor immune response by decreasing Tregs in H NSCC.
Journal ArticleDOI
Consuming a Ketogenic Diet while Receiving Radiation and Chemotherapy for Locally Advanced Lung Cancer and Pancreatic Cancer: The University of Iowa Experience of Two Phase 1 Clinical Trials
Amir Zahra,Melissa A. Fath,Emyleigh Opat,Kranti A. Mapuskar,Sudershan K. Bhatia,Daniel C. Ma,Samuel N. Rodman,Travis Snyders,Catherine A. Chenard,Julie M. Eichenberger-Gilmore,Kellie L. Bodeker,Logan Ahmann,Brian J. Smith,Sandy Vollstedt,Heather Brown,Taher Abu Hejleh,Gerald H. Clamon,Daniel J. Berg,Luke I. Szweda,Douglas R. Spitz,John M. Buatti,Bryan G. Allen +21 more
TL;DR: The preclinical experiments demonstrate that a ketogenic diet increases radiation sensitivity in a pancreatic cancer xenograft model, and demonstrates prolonged survival and increased 4HNE-modfied proteins in animals consuming aketogenic diet combined with radiation compared to radiation alone.
References
More filters
Journal ArticleDOI
Reduced lung-cancer mortality with low-dose computed tomographic screening.
Denise R. Aberle,Amanda M. Adams,Christine D. Berg,William C. Black,Jonathan D. Clapp,Richard M. Fagerstrom,Ilana F. Gareen,Constantine Gatsonis,Pamela M. Marcus,JoRean D. Sicks +9 more
TL;DR: Screening with the use of low-dose CT reduces mortality from lung cancer, as compared with the radiography group, and the rate of death from any cause was reduced.
SEER Cancer Statistics Review, 1975-2003
Lynn A. G. Ries,D. Harkins,Martin Krapcho,Angela B. Mariotto,Barry A. Miller,Eric J. Feuer,Limin X. Clegg,M. P. Eisner,Marie-Josèphe Horner,Nadia Howlader,Matthew J. Hayat,Benjamin F. Hankey,Brenda K. Edwards +12 more
The Health consequences of smoking—50 years of progress : a report of the Surgeon General
TL;DR: The scientific evidence is incontrovertible: inhaling tobacco smoke, particularly from cigarettes, is deadly.
Journal ArticleDOI
Permutation tests for joinpoint regression with applications to cancer rates
TL;DR: A joinpoint regression model is applied to describe continuous changes in the recent trend and the grid-search method is used to fit the regression function with unknown joinpoints assuming constant variance and uncorrelated errors.
Book
International Classification of Diseases for Oncology
TL;DR: This list of diseases for oncology includes cancers of the central nervous system, as well as other types of diseases such as lymphoma, leukaemia, and so on.