Cancer statistics, 2016
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TLDR
Overall cancer incidence trends are stable in women, but declining by 3.1% per year in men, much of which is because of recent rapid declines in prostate cancer diagnoses, and brain cancer has surpassed leukemia as the leading cause of cancer death among children and adolescents.Abstract:
Each year, the American Cancer Society estimates the numbers of new cancer cases and deaths that will occur in the United States in the current year and compiles the most recent data on cancer incidence, mortality, and survival. Incidence data were collected by the National Cancer Institute (Surveillance, Epidemiology, and End Results [SEER] Program), the Centers for Disease Control and Prevention (National Program of Cancer Registries), and the North American Association of Central Cancer Registries. Mortality data were collected by the National Center for Health Statistics. In 2016, 1,685,210 new cancer cases and 595,690 cancer deaths are projected to occur in the United States. Overall cancer incidence trends (13 oldest SEER registries) are stable in women, but declining by 3.1% per year in men (from 2009-2012), much of which is because of recent rapid declines in prostate cancer diagnoses. The cancer death rate has dropped by 23% since 1991, translating to more than 1.7 million deaths averted through 2012. Despite this progress, death rates are increasing for cancers of the liver, pancreas, and uterine corpus, and cancer is now the leading cause of death in 21 states, primarily due to exceptionally large reductions in death from heart disease. Among children and adolescents (aged birth-19 years), brain cancer has surpassed leukemia as the leading cause of cancer death because of the dramatic therapeutic advances against leukemia. Accelerating progress against cancer requires both increased national investment in cancer research and the application of existing cancer control knowledge across all segments of the population.read more
Citations
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Biology of colorectal cancer.
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ILC2-modulated T cell-to-MDSC balance is associated with bladder cancer recurrence
Mathieu F. Chevalier,Sara Trabanelli,Julien Racle,Julien Racle,Bérengère Salomé,Valérie Cesson,Dalila Gharbi,Perrine Bohner,Sonia Domingos-Pereira,Florence Dartiguenave,Anne-Sophie Fritschi,Daniel E. Speiser,Cyrill A. Rentsch,David Gfeller,David Gfeller,Patrice Jichlinski,Denise Nardelli-Haefliger,Camilla Jandus,Laurent Derré +18 more
TL;DR: The T cell–to-MDSC balance, associated with a skewing toward type 2 immunity, may predict bladder tumor recurrence and influence the mortality of patients with muscle-invasive cancer.
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Immune checkpoint inhibitors and elderly people: A review
Amaury Daste,Charlotte Domblides,Marine Gross-Goupil,Camille Chakiba,Amandine Quivy,Valérie Cochin,Erwan de Mones,Nicolas Larmonier,Pierre Soubeyran,Alain Ravaud +9 more
TL;DR: The impact of ageing and immunosenescence on immune system functions is discussed, and the safety and efficacy of immune checkpoint inhibitors in elderly patients are assessed, principally from the data of pivotal clinical trials with subgroup analysis.
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The value of pyrans as anticancer scaffolds in medicinal chemistry
Dinesh Kumar,Pooja Sharma,Harmanpreet Singh,Kunal Nepali,Girish Kumar Gupta,Subheet Kumar Jain,Fidele Ntie-Kang,Fidele Ntie-Kang +7 more
TL;DR: The promising activities revealed by these pyran-based scaffolds undoubtedly place them at the forefront for the discovery of prospective drug candidates, and could therefore be of great interest to researchers working on the synthesis of antitumour drug candidates.
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Alterations of gastric mucosal microbiota across different stomach microhabitats in a cohort of 276 patients with gastric cancer.
Xiaosun Liu,Li Shao,Xia Liu,Feng Ji,Ying Mei,Yiwen Cheng,Fengping Liu,Chongxian Yan,Lanjuan Li,Zongxin Ling +9 more
TL;DR: New insights are provided into the roles of gastric microbiota in different stomach microhabitats in gastric carcinogenesis, especially the pathogenesis of HP.
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TL;DR: This list of diseases for oncology includes cancers of the central nervous system, as well as other types of diseases such as lymphoma, leukaemia, and so on.