Cancer statistics, 2016
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TLDR
Overall cancer incidence trends are stable in women, but declining by 3.1% per year in men, much of which is because of recent rapid declines in prostate cancer diagnoses, and brain cancer has surpassed leukemia as the leading cause of cancer death among children and adolescents.Abstract:
Each year, the American Cancer Society estimates the numbers of new cancer cases and deaths that will occur in the United States in the current year and compiles the most recent data on cancer incidence, mortality, and survival. Incidence data were collected by the National Cancer Institute (Surveillance, Epidemiology, and End Results [SEER] Program), the Centers for Disease Control and Prevention (National Program of Cancer Registries), and the North American Association of Central Cancer Registries. Mortality data were collected by the National Center for Health Statistics. In 2016, 1,685,210 new cancer cases and 595,690 cancer deaths are projected to occur in the United States. Overall cancer incidence trends (13 oldest SEER registries) are stable in women, but declining by 3.1% per year in men (from 2009-2012), much of which is because of recent rapid declines in prostate cancer diagnoses. The cancer death rate has dropped by 23% since 1991, translating to more than 1.7 million deaths averted through 2012. Despite this progress, death rates are increasing for cancers of the liver, pancreas, and uterine corpus, and cancer is now the leading cause of death in 21 states, primarily due to exceptionally large reductions in death from heart disease. Among children and adolescents (aged birth-19 years), brain cancer has surpassed leukemia as the leading cause of cancer death because of the dramatic therapeutic advances against leukemia. Accelerating progress against cancer requires both increased national investment in cancer research and the application of existing cancer control knowledge across all segments of the population.read more
Citations
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Journal ArticleDOI
Artificial Mini Dendritic Cells Boost T Cell-Based Immunotherapy for Ovarian Cancer
Shanshan Cheng,Cong Xu,Yue Jin,Yu Li,Cheng Zhong,Jun Ma,Jiani Yang,Nan Zhang,Yuan Li,Chao Wang,Zhiyou Yang,Yu Wang +11 more
TL;DR: In a mouse model of ovarian cancer,mini DCs exhibit superior therapeutic and prophylactic efficacy against cancer including delayed tumor growth and reduced tumor metastasis compared with DC vaccine, suggesting that mini DCs may serve as a facile and potent vaccine to boost anticancer immunotherapy.
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New therapies for advanced, recurrent, and metastatic endometrial cancers
Vicky Makker,Angela K Green,Robert M. Wenham,David G. Mutch,Brittany A. Davidson,David Miller +5 more
TL;DR: Current and emerging treatment options for endometrial cancer are discussed, including chemotherapy, targeted therapy, and immunotherapy, which are essential for the advancement of cancer care for women, which is threatened by a severe enrollment decline of approximately 80% for gynecologic oncology clinical trials.
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Characterization of outcomes in patients with metastatic non-small cell lung cancer treated with programmed cell death protein 1 inhibitors past RECIST version 1.1-defined disease progression in clinical trials.
Dickran Kazandjian,Dickran Kazandjian,Patricia Keegan,Daniel L. Suzman,Richard Pazdur,Gideon M. Blumenthal +5 more
TL;DR: The findings of a pooled analysis of three clinical trials where treatment of patients with mNSCLC permitted TPP in terms of reduction in the sum of target lesions following initial RECIST-defined progression suggest that a treatment strategy that includes TPP may not benefit the overall population.
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Self-immolative nanoparticles for simultaneous delivery of microRNA and targeting of polyamine metabolism in combination cancer therapy.
Ying Xie,Tracy Murray-Stewart,Yazhe Wang,Fei Yu,Jing Li,Laurence J. Marton,Robert A. Casero,David Oupický +7 more
TL;DR: The reported findings validate the self‐immolative nanoparticles as delivery vectors of therapeutic miRNA capable of simultaneously targeting dysregulated polyamine metabolism in cancer, thereby providing an elegant and efficient approach to combination nanomedicines.
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Efficacy of bacillus Calmette-Guérin Strains for Treatment of Nonmuscle Invasive Bladder Cancer: A Systematic Review and Network Meta-Analysis
Brock E. Boehm,John E. Cornell,Hanzhang Wang,Neelam Mukherjee,Jacob S. Oppenheimer,Robert S. Svatek +5 more
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