Cardiomyocyte Cell Cycle Regulation
Reads0
Chats0
TLDR
This compilation of approaches and studies that have shed some light on cardiomyocyte cell cycle regulation is reviewed and it is hoped that this compilation will serve to stimulate thought and experimentation in this intriguing area of cardiomeocyte cell biology.Abstract:
Although rapid progress is being made in many areas of molecular cardiology, issues pertaining to the origins of heart-forming cells, the mechanisms responsible for cardiogenic induction, and the pathways that regulate cardiomyocyte proliferation during embryonic and adult life remain unanswered. In the present study, we review approaches and studies that have shed some light on cardiomyocyte cell cycle regulation. For reference, an initial description of cardiomyogenic induction and morphogenesis is provided, which is followed by a summary of published cell cycle analyses during these stages of cardiac ontology. A review of studies examining cardiomyocyte cell cycle analysis and de novo cardiomyogenic induction in the adult heart is then presented. Finally, studies in which cardiomyocyte cell cycle activity was experimentally manipulated in vitro and in vivo are reviewed. It is hoped that this compilation will serve to stimulate thought and experimentation in this intriguing area of cardiomyocyte cell biology.read more
Citations
More filters
Journal ArticleDOI
Cardiomyocytes derived from human embryonic stem cells in pro-survival factors enhance function of infarcted rat hearts
Michael A. Laflamme,Kent Chen,Anna V. Naumova,Veronica Muskheli,James A. Fugate,Sarah K. Dupras,Hans Reinecke,Chunhui Xu,Mohammad Hassanipour,Chris O'Sullivan,Lila R. Collins,Yinhong Chen,Elina Minami,Edward A. Gill,Shuichi Ueno,Chun Yuan,Joseph K. Gold,Charles E. Murry +17 more
TL;DR: This work generated highly purified human cardiomyocytes using a readily scalable system for directed differentiation that relies on activin A and BMP4, and identified a cocktail of pro-survival factors that limitsCardiomyocyte death after transplantation.
Journal ArticleDOI
Heart Regeneration in Zebrafish
TL;DR: It is demonstrated histologically that zebrafish fully regenerate hearts within 2 months of 20% ventricular resection, showing that injury-induced cardiomyocyte proliferation in zebra fish can overcome scar formation, allowing cardiac muscle regeneration.
Journal ArticleDOI
Regenerating the heart.
TL;DR: Future research is likely to focus on improving the ability to guide the differentiation of stem cells, control their survival and proliferation, identify factors that mediate their homing and modulate the heart's innate inflammatory and fibrotic responses.
Journal ArticleDOI
Neuregulin1/ErbB4 Signaling Induces Cardiomyocyte Proliferation and Repair of Heart Injury
TL;DR: It is shown that differentiated heart muscle cells, cardiomyocytes, can be induced to proliferate and regenerate and an underlying molecular mechanism for controlling this process that involves the growth factor neuregulin1 (NRG1) and its tyrosine kinase receptor, ErbB4 is identified.
Journal ArticleDOI
Electromechanical integration of cardiomyocytes derived from human embryonic stem cells.
Izhak Kehat,Leonid Khimovich,Oren Caspi,Amira Gepstein,Rona Shofti,Gil Arbel,Irit Huber,Jonathan Satin,Joseph Itskovitz-Eldor,Lior Gepstein +9 more
TL;DR: The potential of hES-cell cardiomyocytes to act as a rate-responsive biological pacemaker and for future myocardial regeneration strategies are demonstrated.
References
More filters
Journal ArticleDOI
Bone marrow cells regenerate infarcted myocardium
Donald Orlic,Jan Kajstura,Stefano Chimenti,Igor Jakoniuk,Stacie M. Anderson,Baosheng Li,James Pickel,Ronald D.G. McKay,Bernardo Nadal-Ginard,David M. Bodine,Annarosa Leri,Piero Anversa +11 more
TL;DR: It is indicated that locally delivered bone marrow cells can generate de novo myocardium, ameliorating the outcome of coronary artery disease.
Journal ArticleDOI
Human Mesenchymal Stem Cells Differentiate to a Cardiomyocyte Phenotype in the Adult Murine Heart
TL;DR: The persistence of the engrafted hMSCs and their in situ differentiation in the heart may represent the basis for using these adult stem cells for cellular cardiomyoplasty.
Journal ArticleDOI
Regeneration of ischemic cardiac muscle and vascular endothelium by adult stem cells
Kathyjo A. Jackson,Susan M. Majka,Hongyu Wang,Jennifer Pocius,Craig J. Hartley,Mark W. Majesky,Mark L. Entman,Lloyd H. Michael,Karen K. Hirschi,Margaret A. Goodell +9 more
TL;DR: The results demonstrate the cardiomyogenic potential of hematopoietic stem cells and suggest a therapeutic strategy that eventually could benefit patients with myocardial infarction.
Journal ArticleDOI
Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion
Naohiro Terada,Takashi Hamazaki,Masahiro Oka,Masanori Hoki,Diana M. Mastalerz,Yuka Nakano,Edwin M. Meyer,Laurence Morel,Bryon E. Petersen,Edward W. Scott +9 more
TL;DR: It is demonstrated that mouse bone marrow cells can fuse spontaneously with embryonic stem cells in culture in vitro that contains interleukin-3, which, without detailed genetic analysis, might be interpreted as ‘dedifferentiation’ or transdifferentiation.
Journal ArticleDOI
Changing potency by spontaneous fusion
TL;DR: A mechanism by which progenitor cells of the central nervous system can give rise to non-neural derivatives is defined, and it is proposed that transdetermination consequent to cell fusion could underlie many observations otherwise attributed to an intrinsic plasticity of tissue stem cells.