Cardiovascular Risk Factors in Adolescents Born Preterm
Marika Sipola-Leppänen,Marja Vääräsmäki,Marjaana Tikanmäki,Petteri Hovi,Satu Miettola,Aimo Ruokonen,Anneli Pouta,Anneli Pouta,Marjo-Riitta Järvelin,Eero Kajantie +9 more
Reads0
Chats0
TLDR
In this article, the association between preterm birth and cardiovascular risk factors in 6642 16-year-old adolescents of the population-based Northern Finland Birth Cohort 1986 was studied.Abstract:
BACKGROUND: Adolescents and adults born as small preterm infants show more pronounced risk factors of cardiovascular disease. Whether similar risks apply across all degrees of preterm birth is poorly known. METHODS: We studied the association between preterm birth and cardiovascular risk factors in 6642 16-year-old adolescents of the population-based Northern Finland Birth Cohort 1986. Of these, 79 (1.2%) were born at RESULTS: Girls born early preterm had 6.7 mm Hg (95% confidence interval: 3.1–10.2) higher systolic blood pressure (BP) and 3.5 mm Hg (1.1–5.8) higher diastolic BP, but no difference in serum lipid levels compared with control girls. Boys showed no differences in BP, but boys born early preterm had 6.7% (0.2%–13.7%) higher total cholesterol, 11.7% (2.1%–22.3%) higher low-density lipoprotein cholesterol, and 12.3% (3.1%–22.4%) higher apolipoprotein B concentrations. The differences were similar (BP) or stronger (lipids) when adjusted for maternal smoking, birth weight SD score, parental education, pubertal stage, BMI, and lifestyle. There were similar associations with length of gestation as a continuous variable. Accordingly, mean differences between late preterm and controls were in the same direction but weaker, although most were not statistically significant. CONCLUSIONS: Preterm birth was associated with elevated BP in adolescent girls and an atherogenic lipid profile in boys. Because these associations were strongest among those born early preterm, our findings are consistent with a dose-response relationship between shorter length of gestation and cardiovascular risk factors.read more
Citations
More filters
Journal ArticleDOI
Cardiometabolic Risk Factors in Young Adults Who Were Born Preterm
Marika Sipola-Leppänen,Marja Vääräsmäki,Marjaana Tikanmäki,Hanna-Maria Matinolli,Satu Miettola,Petteri Hovi,Karoliina Wehkalampi,Aimo Ruokonen,Jouko Sundvall,Anneli Pouta,Johan G. Eriksson,Marjo-Riitta Järvelin,Eero Kajantie +12 more
TL;DR: In this paper, the authors investigated cardiometabolic risk factors in young adults who were born at any degree of prematurity in the Preterm Birth and Early Life Programming of Adult Health and Disease (ESTER) Study, a population-based cohort study of individuals born in 1985-1989 in Northern Finland.
Journal ArticleDOI
Adults born preterm: a review of general health and system-specific outcomes.
TL;DR: A small, but a significant fraction of adults born at preterm gestations remain at higher risk for neurological, personality and behavioural abnormalities, cardio‐pulmonary functional limitations, systemic hypertension and metabolic syndrome compared to their term‐born counterparts.
Journal ArticleDOI
Long-term metabolic risk among children born premature or small for gestational age.
Verónica Mericq,Alejandro Martinez-Aguayo,Ricardo Uauy,Ricardo Uauy,Germán Iñiguez,Manouk van der Steen,Anita C. S. Hokken-Koelega +6 more
TL;DR: The available human data supporting increased metabolic risk among children born premature or small for gestational age; the adrenal and pubertal modifications that contribute to this risk; metabolic changes that occur during adolescence and early adulthood; and approaches to potentially modify or decrease risk of metabolic disease are reviewed.
Journal ArticleDOI
Long-Term Healthcare Outcomes of Preterm Birth: An Executive Summary of a Conference Sponsored by the National Institutes of Health.
Tonse N.K. Raju,Victoria L. Pemberton,Saroj Saigal,Carol J. Blaisdell,Marva Moxey-Mims,Sonia Buist +5 more
TL;DR: The Journal of Pediatrics, The - In PressProof corrected by the author available online since lundi 31 octobre 2016 as mentioned in this paper, The -In Press proof corrected by as mentioned in this paper.
Journal ArticleDOI
Fetal programming and the angiotensin-(1-7) axis: a review of the experimental and clinical data.
Andrew M South,Hossam A. Shaltout,Lisa K. Washburn,Alexa S. Hendricks,Debra I. Diz,Mark C. Chappell +5 more
TL;DR: The potential role of the ACE2-Ang-(1-7)-Mas receptor (MasR) axis of the RAS in fetal programming events and cardiovascular and renal dysfunction is evaluated.
References
More filters
Journal ArticleDOI
A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010
Stephen S Lim,Theo Vos,Abraham D. Flaxman,Goodarz Danaei,Kenji Shibuya,Heather Adair-Rohani,Mohammad A. AlMazroa,Markus Amann,H. Ross Anderson,Kathryn G. Andrews,Martin J. Aryee,Charles Atkinson,Loraine J. Bacchus,Adil N. Bahalim,Kalpana Balakrishnan,John R. Balmes,Suzanne Barker-Collo,Amanda J Baxter,Michelle L. Bell,Jed D. Blore,Fiona M. Blyth,Carissa Bonner,Guilherme Borges,Rupert R A Bourne,Michel Boussinesq,Michael Brauer,Peter Brooks,Nigel Bruce,Bert Brunekreef,Claire Bryan-Hancock,Chiara Bucello,Rachelle Buchbinder,Fiona Bull,Richard T. Burnett,Tim Byers,Bianca Calabria,Jonathan R. Carapetis,Emily Carnahan,Zoë Chafe,Fiona J Charlson,Honglei Chen,Jian Shen Chen,Andrew T. A. Cheng,Jennifer C. Child,Aaron Cohen,K. Ellicott Colson,Benjamin C Cowie,Sarah C. Darby,Susan Darling,Adrian Davis,Louisa Degenhardt,Frank Dentener,Don C. Des Jarlais,Karen Devries,Mukesh Dherani,Eric L. Ding,E. Ray Dorsey,Tim Driscoll,Karen Edmond,S. Ali,Rebecca E. Engell,Patricia J. Erwin,Saman Fahimi,Gail Falder,Farshad Farzadfar,Alize J. Ferrari,Mariel M. Finucane,Seth Flaxman,F.G.R. Fowkes,Greg Freedman,Michael Freeman,Emmanuela Gakidou,Santu Ghosh,Edward Giovannucci,Gerhard Gmel,Kathryn Graham,Rebecca Grainger,Rebecca Grainger,Bridget F. Grant,David Gunnell,Hialy R. Gutierrez,Wayne Hall,Hans W. Hoek,Anthony Hogan,H. Dean Hosgood,Damian G Hoy,Howard Hu,Bryan Hubbell,Sally Hutchings,Sydney E. Ibeanusi,Gemma Jacklyn,Rashmi Jasrasaria,Jost B. Jonas,Haidong Kan,John A. Kanis,Nicholas J Kassebaum,Norito Kawakami,Young-Ho Khang,Shahab Khatibzadeh,Jon-Paul Khoo,Cindy Kok,Francine Laden,Ratilal Lalloo,Qing Lan,Tim Lathlean,Janet L Leasher,James Leigh,Yang Li,John K Lin,Steven E. Lipshultz,Stephanie J. London,Rafael Lozano,Yuan Lu,Joelle Mak,Reza Malekzadeh,Leslie Mallinger,Wagner Marcenes,Lyn March,Robin Marks,Randall V. Martin,Paul McGale,John J. McGrath,Sumi Mehta,Ziad A. Memish,George A. Mensah,Tony R. Merriman,Renata Micha,Renata Micha,Catherine Michaud,Vinod Mishra,Khayriyyah Mohd Hanafiah,Ali A. Mokdad,Lidia Morawska,Dariush Mozaffarian,Tasha B. Murphy,Mohsen Naghavi,Bruce Neal,Paul K. Nelson,Joan M. Nolla,Rosana E. Norman,Casey Olives,Saad B. Omer,Jessica Orchard,Richard H. Osborne,Bart Ostro,Andrew Page,Kiran Pandey,Charles D. H. Parry,Erin Passmore,Jayadeep Patra,Neil Pearce,Pamela M. Pelizzari,Max Petzold,Michael Phillips,Daniel Pope,C. Arden Pope,John Powles,Mayuree Rao,Homie Razavi,Eva Rehfuess,Jürgen Rehm,Beate Ritz,Frederick P. Rivara,Thomas Roberts,Carolyn Robinson,Jose Adolfo Rodriguez-Portales,Isabelle Romieu,Robin Room,Lisa C. Rosenfeld,Ananya Roy,Lesley Rushton,Joshua A. Salomon,Uchechukwu Sampson,Lidia Sanchez-Riera,Ella Sanman,Amir Sapkota,Soraya Seedat,Peilin Shi,Kevin D. Shield,Rupak Shivakoti,Gitanjali M Singh,David A. Sleet,Emma Smith,Kirk R. Smith,Nicolas J. C. Stapelberg,Kyle Steenland,Heidi Stöckl,Lars Jacob Stovner,Kurt Straif,Lahn Straney,George D. Thurston,Jimmy H. Tran,Rita Van Dingenen,Aaron van Donkelaar,J. Lennert Veerman,Lakshmi Vijayakumar,Robert G. Weintraub,Myrna M. Weissman,Richard A. White,Harvey Whiteford,Steven T. Wiersma,James D. Wilkinson,Hywel C Williams,Warwick Williams,Nick Wilson,Anthony D. Woolf,Paul S. F. Yip,Jan M Zielinski,Alan D. Lopez,Christopher J L Murray,Majid Ezzati +210 more
TL;DR: In this paper, the authors estimated deaths and disability-adjusted life years (DALYs; sum of years lived with disability [YLD] and years of life lost [YLL]) attributable to the independent effects of 67 risk factors and clusters of risk factors for 21 regions in 1990 and 2010.
Journal ArticleDOI
Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies.
TL;DR: Throughout middle and old age, usual blood pressure is strongly and directly related to vascular (and overall) mortality, without any evidence of a threshold down to at least 115/75 mm Hg.
Journal ArticleDOI
Epidemiology and causes of preterm birth
TL;DR: A short cervical length and a raised cervical-vaginal fetal fibronectin concentration are the strongest predictors of spontaneous preterm birth.
Journal ArticleDOI
The fourth report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents
Bonita Falkner,Stephen R. Daniels,Joseph T. Flynn,Samuel S. Gidding,Lee A. Green,Julie R. Ingelfinger,Ronald M. Lauer,Bruce Z. Morgenstern,Ronald J. Portman,Ronald J. Prineas,Albert P. Rocchini,Bernard Rosner,Alan R. Sinaiko,Nicolas Stettler,Elaine M. Urbina,Edward J. Roccella,Tracey R. Hoke,Carl E. Hunt,Gail D. Pearson,Joanne Karimbakas,Ann Horton +20 more
Journal ArticleDOI
Use and Abuse of HOMA Modeling
TL;DR: The HOMA model has become a widely used clinical and epidemiological tool and, when used appropriately, it can yield valuable data, however, as with all models, the primary input data needs to be robust, and the data need to be interpreted carefully.