Journal ArticleDOI
Challenges translating breast cancer gene signatures into the clinic
TLDR
The hurdles in the development and validation of molecular classification systems, and prognostic and predictive signatures based on microarray gene-expression profiling are discussed and it is suggested that similar challenges are likely to be encountered in translating next-generation sequencing data into clinically useful information.Abstract:
The advent of microarray-based gene-expression profiling a decade ago raised high expectations for rapid advances in breast cancer classification, prognostication and prediction. Despite the development of molecular classifications, and prognostic and predictive gene-expression signatures, microarray-based studies have not yielded definitive answers to many of the questions that remain germane for the successful implementation of personalized medicine. There are a lack of robust signatures to predict benefit from specific therapeutic agents and it is still not possible to predict prognosis or chemotherapy treatment response in specific disease subsets accurately, such as triple-negative breast cancer. We discuss the hurdles in the development and validation of molecular classification systems, and prognostic and predictive signatures based on microarray gene-expression profiling. We suggest that similar challenges are likely to be encountered in translating next-generation sequencing data into clinically useful information. Finally we highlight strategies for the development of clinically useful molecular predictors in the future.read more
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Journal ArticleDOI
Molecular Pathology of the Breast.
TL;DR: Phenotypes and genotypes of breast cancer are presented, along with the role of biomarkers, gene profiling, and hormone receptors, and targeted therapies and prognostic indicators are presented.
Book ChapterDOI
Molecular Pathology and Diagnostics of Breast Cancer
TL;DR: Significant advancements in a variety of scientific disciplines in basic research, integration of next-generation sequencing technologies, and innovative computational and mathematical methods in integration of diverse data types on a large scale will likely translate into clinical applications such as breast cancer diagnosis.
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The scalable Birth-Death MCMC Algorithm for Mixed Graphical Model Learning with Application to Genomic Data Integration
TL;DR: A novel mixed graphical model approach to analyze multi-omic data of different types and perform model selection by extending the Birth-Death MCMC (BDMCMC) algorithm is proposed and found that this method is superior in terms of both computational efficiency and the accuracy of the model selection results.
Book ChapterDOI
Molecular Classification and Prognostic Signatures of Breast Tumors
TL;DR: The markedly extensive breast cancer heterogeneity combined with the lack of reliable predictive factors among these categories limits their ability to distinguish subtle phenotypic differences that may present relevant therapeutic implications.
Application of personalised medicine to solid tumours: opportunities and challenges
TL;DR: This review will provide an overview on the current state of personalised medicine in cancer by Discussion of the use and development of the various technologies will help to understand the opportunities and challenges that arise when novel technologies are implemented.
References
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Hercbergs,M Yoshimoto,Gerrit DeBoer,Alexander H.G. Paterson,JW Meakin,T. Panzarella,Y. Shan,Y. F. Shao,X. Wang,D. B. Zhao,Z. M. Chen,H. C. Pan,J. Bahi,M. Reid,M. Spittle,G. P. Deutsch,F. Senanayake,D. L. W. Kwong,Angelo Raffaele Bianco,Chiara Carlomagno,M. De Laurentiis,S. De Placido,Aman U. Buzdar,Tae C Smith,Jonas Bergh,Lars Holmberg,Göran Liljegren,Jan Nilsson,M. Seifert,P. Sevelda,C. C. Zielinsky,R. B. Buchanan,M. Cross,G.T. Royle,Janet A. Dunn,Robert Kerrin Hills,Michael Lee,J. M. Morrison,D. Spooner,A. Litton,Rowan T. Chlebowski,H. Caffier +412 more
TL;DR: The 10-year and 15-year effects of various systemic adjuvant therapies on breast cancer recurrence and survival are reported and it is found that the cumulative reduction in mortality is more than twice as big at 15 years as at 5 years after diagnosis.
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