Changes in DNA Methylation Patterns in Subjects Exposed to Low-Dose Benzene
Valentina Bollati,Andrea A. Baccarelli,Lifang Hou,Matteo Bonzini,Silvia Fustinoni,Domenico Maria Cavallo,Hyang-Min Byun,Jia Yi Jiang,Barbara Marinelli,Angela Cecilia Pesatori,Pier Alberto Bertazzi,Allen S. Yang +11 more
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TLDR
This is the first human study to link altered DNA methylation, reproducing the aberrant epigenetic patterns found in malignant cells, to low-level carcinogen exposure.Abstract:
Aberrant DNA methylation patterns, including global hypomethylation, gene-specific hypermethylation/hypomethylation, and loss of imprinting (LOI), are common in acute myelogenous leukemia (AML) and other cancer tissues We investigated for the first time whether such epigenetic changes are induced in healthy subjects by low-level exposure to benzene, a widespread pollutant associated with AML risk Blood DNA samples and exposure data were obtained from subjects with different levels of benzene exposure, including 78 gas station attendants, 77 traffic police officers, and 58 unexposed referents in Milan, Italy (personal airborne benzene range, 020) This is the first human study to link altered DNA methylation, reproducing the aberrant epigenetic patterns found in malignant cells, to low-level carcinogen exposureread more
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References
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A simple method for estimating global DNA methylation using bisulfite PCR of repetitive DNA elements
Allen S. Yang,Marcos R. Estecio,Ketan Doshi,Yutaka Kondo,Eloiza H. Tajara,Jean Pierre J. Issa +5 more
TL;DR: This method is less labor intensive and requires less DNA than previous methods of assessing global DNA methylation, and can be used as a surrogate marker of genome-wide methylation changes.
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Oxidative damage to methyl-CpG sequences inhibits the binding of the methyl-CpG binding domain (MBD) of methyl-CpG binding protein 2 (MeCP2)
Victoria Valinluck,Hsin-Hao Tsai,Daniel K. Rogstad,Artur Burdzy,Adrian Bird,Lawrence C. Sowers +5 more
TL;DR: Oxidative damage to DNA could result in heritable, epigenetic changes in chromatin organization, and oxidation of either a single guanine to 8-oxoG or of a single 5mC to HmC, significantly inhibits binding of the MBD to the oligonucleotide duplex, reducing the binding affinity.
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TL;DR: There is a general deregulation of CpG island methylation in leukemia and that hypermethylation is not limited to single genes, but a number of genes are methylated concurrently.
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Chronic inorganic arsenic exposure induces hepatic global and individual gene hypomethylation: implications for arsenic hepatocarcinogenesis
TL;DR: Long-term exposure of mice to arsenic in the drinking water can induce aberrant gene expression, global DNA hypomethylation, and the hypometHylation of the ER-alpha gene promoter, all of which could potentially contribute to arsenic hepatocarcinogenesis.
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Vincent L. Wilson,Peter A. Jones +1 more
TL;DR: Ccinogenic agents may cause heritable changes in 5-methylcytosine patterns in certain cell types by a variety of mechanisms, including adduct formation, induction of apurinic sites and single-strand breaks and direct inactivation of DNA methyltransferase.
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