Open AccessJournal Article
Characterization of murine lung interstitial macrophages in comparison with alveolar macrophages in vitro.
G Franke-Ullmann,C Pförtner,P Walter,Christiane Steinmüller,M L Lohmann-Matthes,Lester Kobzik +5 more
TLDR
Alveolar macrophages appear to be particularly effective as nonspecific first line defense cells against infectious agents, whereas INT are equipped to cooperate with interstitial lymphocytes in inducing a specific immune reaction.Abstract:
The present study was performed to characterize the immunologic potential of interstitial macrophages (INT) in comparison with alveolar macrophages (AL). The data showed that AL, compared with INT, have a more efficient phagocytic potential. In addition, they have a strong microbicidal activity and secrete large amounts of reactive oxygen radicals, nitric oxides, TNF, and IFN on appropriate stimulation. They also exert strong tumoricidal and parasiticidal activities. In contrast, INT are more efficient in releasing immunoregulatory cytokines such as IL-1 and IL-6. As determined by Ab staining, INT express more MHC class II molecules and are more effective in functioning as accessory cells for mitogen-stimulated lymphocyte proliferation compared with AL. Thus, AL appear to be particularly effective as nonspecific first line defense cells against infectious agents, whereas INT are equipped to cooperate with interstitial lymphocytes in inducing a specific immune reaction.read more
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Lung interstitial macrophages alter dendritic cell functions to prevent airway allergy in mice
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Pulmonary macrophages: key players in the innate defence of the airways
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Depletion of Alveolar Macrophages during Influenza Infection Facilitates Bacterial Superinfections
TL;DR: It is concluded that resident AM depletion occurs during influenza infection, which establishes a niche for secondary pneumococcal infection by altering early cellular innate immunity in the lungs, resulting in pneumococCal outgrowth and lethal pneumonia.
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Alveolar macrophages have a protective antiinflammatory role during murine pneumococcal pneumonia
Sylvia Knapp,Jaklien C. Leemans,Sandrine Florquin,Judith Branger,Nico A. Maris,Jennie M. Pater,Nico van Rooijen,Tom van der Poll +7 more
TL;DR: The data suggest that AMs are indispensable in the host response to pneumococcal pneumonia by means of their capacity to modulate inflammation, possibly via elimination of apoptotic PMNs.
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Update on Macrophage Clearance of Inhaled Micro- and Nanoparticles
TL;DR: Uptake by spontaneous or stimulated pinocytosis or electrokinetic phenomena may become more important and translocation of nanometer-sized particles into the interstitium and to the blood circulation brings them into contact with other fluids; altered particle properties may influence particle uptake.
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