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Chem. Pharm. Bull.(オピニオン)
國郎 小笠原
- Vol. 43, Iss: 12, pp 1161
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The article was published on 2007-12-01 and is currently open access. It has received 1121 citations till now.read more
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Regucalcin as a potential biomarker for metabolic and neuronal diseases.
TL;DR: Serum regucalcin has been found to increase with liver injury, and also urinary reguc alcin is elevated with kidney damage, suggesting a useful tool as biomarker for diagnosis, and regucAlcin has be good tool in early diagnosis for Alzheimer’s disease and other brain diseases.
Journal ArticleDOI
Solid Dispersions of Chitosan Glutamate for the Local Delivery of Miconazole: Characterization and In Vitro Activity
TL;DR: Results suggest that the released drug was the fraction of drug desorbed from the CHG particle surface, while a residual amount of drug remained associated or entrapped within them, and the inclusion of MCN in spray-dried microparticles generally did not improve the activity of the drug.
Journal ArticleDOI
Purification and characterization of laccase secreted by Phellinus linteus MTCC-1175 and its role in the selective oxidation of aromatic methyl group.
TL;DR: A laccase from the culture filtrate of Phellinus linteus MTCC-1175 has been purified to homogeneity using ABTS as the mediator and the enzyme transformed toluene, 3-nitrotoluene and 4-chlorotoluenes to benzaldehyde,3-nitrobenzaldehyde and4-chlorobenzaldehyde, respectively.
Journal Article
An Green and Efficient OnePot Synthesis of Coumari n Derivatives Catalyzed by Cerium(IV) triflate at Room Temperature
TL;DR: In this article, a Cerium(IV) triflate was employed as a catalyst for facile preparation of coumarin derivatives via the one pot Pechmann condensation of phenol derivatives with a β ketoester.
Journal ArticleDOI
Isoxazole derivatives as new nitric oxide elicitors in plants
Anca Oancea,Emilian Georgescu,Florentina Georgescu,Alina Nicolescu,Elena Iulia Oprita,Catalina Tudora,Lucian Vladulescu,Marius-Constantin Vladulescu,Florin Oancea,Calin Deleanu +9 more
TL;DR: Several 3,5-disubstituted isoxazoles were obtained in good yields by regiospecific 1,3-dipolar cycloaddition reactions between aromatic nitrile oxides generated in situ from the corresponding hydroxyimidoyl chlorides with non-symmetrical activated alkynes in the presence of catalytic amounts of copper(I) iodide.
References
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Kinetic modeling on drug release from controlled drug delivery systems.
TL;DR: The mathematical modeling can ultimately help to optimize the design of a therapeutic device to yield information on the efficacy of various release models.
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Fluorescent Sensors for Measuring Metal Ions in Living Systems
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Dietary phenolics: chemistry, bioavailability and effects on health.
TL;DR: This review summarizes the chemistry, biosynthesis and occurrence of the compounds involved, namely the C6-C3-C6 flavonoids-anthocyanins, dihydrochalcones, Flavan-3-ols, flavanones, flavones, Flavonols and isoflavones, and the mechanisms underlying these processes are discussed.
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Amide bond formation: beyond the myth of coupling reagents
Eric Valeur,Mark Bradley +1 more
TL;DR: This critical review is focussed on the most recently developed coupling reagents with particular attention paid to the pros and cons of the plethora of "acronym" based reagents.
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Facile Discrimination of Aldose Enantiomers by Reversed-Phase HPLC
TL;DR: The reaction was applied to the determination of absolute configuration the sugar residues of an aroma precursor and direct HPLC analysis of the reaction mixture and UV detection at 250 nm discriminated D- and L-enantiomers of aldoses.