Open Access
Chem. Pharm. Bull.(オピニオン)
國郎 小笠原
- Vol. 43, Iss: 12, pp 1161
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The article was published on 2007-12-01 and is currently open access. It has received 1121 citations till now.read more
Citations
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Kinetic modeling on drug release from controlled drug delivery systems.
TL;DR: The mathematical modeling can ultimately help to optimize the design of a therapeutic device to yield information on the efficacy of various release models.
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Fluorescent Sensors for Measuring Metal Ions in Living Systems
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Dietary phenolics: chemistry, bioavailability and effects on health.
TL;DR: This review summarizes the chemistry, biosynthesis and occurrence of the compounds involved, namely the C6-C3-C6 flavonoids-anthocyanins, dihydrochalcones, Flavan-3-ols, flavanones, flavones, Flavonols and isoflavones, and the mechanisms underlying these processes are discussed.
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Amide bond formation: beyond the myth of coupling reagents
Eric Valeur,Mark Bradley +1 more
TL;DR: This critical review is focussed on the most recently developed coupling reagents with particular attention paid to the pros and cons of the plethora of "acronym" based reagents.
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Facile Discrimination of Aldose Enantiomers by Reversed-Phase HPLC
TL;DR: The reaction was applied to the determination of absolute configuration the sugar residues of an aroma precursor and direct HPLC analysis of the reaction mixture and UV detection at 250 nm discriminated D- and L-enantiomers of aldoses.
References
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Synthesis and Antitumor Activity of Novel Pyrimidinyl Pyrazole Derivatives. III. Synthesis and Antitumor Activity of 3-Phenylpiperazinyl-1-trans-propenes
Hiroyuki Naito,Satoru Ohsuki,Ryo Atsumi,Megumi Minami,Mineko Mochizuki,Kenji Hirotani,Eiji Kumazawa,Akio Ejima +7 more
TL;DR: The 3-cyano-5-fluorophenyl derivative (29b) exhibited potent antitumor activity against several tumor cells including human carcinoma without causing undesirable effects in mice.
Journal ArticleDOI
Structural and bioactive studies of terpenes and cyclopeptides from the Genus Rubia
TL;DR: All 65 terpenes and 44 cyclopeptides with their distributions, physiological activities and melting points (or optical rotations) as reported in 85 references are compiled and structure-activity relationships of these derivatives were briefly discussed.
Journal ArticleDOI
Phellinus linteus mycelium alleviates myocardial ischemia-reperfusion injury through autophagic regulation
Hsing Hui Su,Ya Chun Chu,Jiuan Miaw Liao,Yi Hsin Wang,Ming-Shiou Jan,Chia-Wei Lin,Chiu Yeh Wu,Chin Yin Tseng,Jiin-Cherng Yen,Shiang Suo Huang +9 more
TL;DR: Pretreatment with PL mycelium (PLM) significantly reduced ventricular arrhythmia and mortality due to myocardial IR injury, suggesting that PLM is effective in protecting the myocardium against IR injury.
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Characterization of the synthetic cannabinoid MDMB-CHMCZCA
TL;DR: The synthetic cannabinoid MDMB-CHMCZCA was characterized by various spectroscopic techniques including NMR spectroscopy and tandem mass spectrometry and the enantiomeric purity of samples from test purchases and police seizures was assessed by a self-developed chiral HPLC method.
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Pyrimidine: The Molecule of Diverse Biological and Medicinal Importance
Raghav Mishra,Isha Tomar +1 more
TL;DR: A broad view of the biological and medicinal activity possessed by compounds having pyrimidine nucleus is provided, exhibiting remarkable pharmacological activities.