Open Access
Chem. Pharm. Bull.(オピニオン)
國郎 小笠原
- Vol. 43, Iss: 12, pp 1161
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The article was published on 2007-12-01 and is currently open access. It has received 1121 citations till now.read more
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Kinetic modeling on drug release from controlled drug delivery systems.
TL;DR: The mathematical modeling can ultimately help to optimize the design of a therapeutic device to yield information on the efficacy of various release models.
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Fluorescent Sensors for Measuring Metal Ions in Living Systems
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Dietary phenolics: chemistry, bioavailability and effects on health.
TL;DR: This review summarizes the chemistry, biosynthesis and occurrence of the compounds involved, namely the C6-C3-C6 flavonoids-anthocyanins, dihydrochalcones, Flavan-3-ols, flavanones, flavones, Flavonols and isoflavones, and the mechanisms underlying these processes are discussed.
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Amide bond formation: beyond the myth of coupling reagents
Eric Valeur,Mark Bradley +1 more
TL;DR: This critical review is focussed on the most recently developed coupling reagents with particular attention paid to the pros and cons of the plethora of "acronym" based reagents.
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Facile Discrimination of Aldose Enantiomers by Reversed-Phase HPLC
TL;DR: The reaction was applied to the determination of absolute configuration the sugar residues of an aroma precursor and direct HPLC analysis of the reaction mixture and UV detection at 250 nm discriminated D- and L-enantiomers of aldoses.
References
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The chemistry of bisallenes
TL;DR: Bisallenes are especially useful in isomerization and cycloaddition reactions of all kinds leading to the respective target molecules with high atom economy and often in high yield and substrates for generating molecular complexity in a small number of steps.
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Solubility Temperature Dependence Predicted from 2D Structure
TL;DR: In this paper, a simple procedure was devised to predict enthalpies of solution, ΔH sol, from which the temperature dependence of intrinsic (uncharged form) solubility, log S 0, could be calculated.
Journal ArticleDOI
Determination of digoxin in human serum using stable isotope dilution liquid chromatography/electrospray ionization-tandem mass spectrometry.
TL;DR: The intra- and inter-assay reproducibility and accuracy were satisfactory within the quantification range of 0.20-3.20 ng/ml, and the concentrations of digoxin in the serum samples obtained from digitalized patients were compared to those obtained by radioimmunoassay.
Journal ArticleDOI
Neolignans from Selaginella moellendorffii.
Jing-Xian Zhuo,Yue-Hu Wang,Xing-Li Su,Ren-Qiang Mei,Jun Yang,Yi Kong,Chunlin Long,Chunlin Long +7 more
TL;DR: Several compounds from this plant showed the activity against platelet aggregation induced by ADP or collagen, and the dihydrobenzofuran neolignans (8, 11, and 12) are more potent than the benzofuranNeolignan (13) and other types of neolIGNans (1–7).
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New cytotoxic bicyclic hexapeptides, RA-XXIII and RA-XXIV, from Rubia cordifolia L.
TL;DR: Two new bicyclic hexapeptides, RA-XXIII and RA- XXIV, were isolated from the roots of Rubia cordifolia L. (Rubiaceae) by the analysis of their 2D NMR spectra, chemical methods, and X-ray crystallography.