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Chem. Pharm. Bull.(オピニオン)

國郎 小笠原
- Vol. 43, Iss: 12, pp 1161
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The article was published on 2007-12-01 and is currently open access. It has received 1121 citations till now.

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A synthetic glycosphingolipid-induced antiproliferative effect in melanoma cells is associated with suppression of FAK, Akt, and Erk activation.

Yoshiko Sonoda, +6 more
- 01 Jun 2008 - 
TL;DR: Glycosphingolipid 7, which was identified in the millipede Parafontaria laminata armigera, had an antiproliferative effect on the melanoma cells, and might be a candidate for an inhibitor of cell proliferation in melanomas.
Journal ArticleDOI

Polyyne hybrid compounds from Notopterygium incisum with peroxisome proliferator-activated receptor gamma agonistic effects.

Xin Liu, +13 more
- 21 Oct 2014 - 
TL;DR: In the search for peroxisome proliferator-activated receptor gamma (PPARγ) active constituents from the roots and rhizomes of Notopterygium incisum, 11 new polyacetylene derivatives were isolated as new polyyne hybrid molecules of falcarindiol with sesquiterpenoid or phenylpropanoid moieties, named notoethers A–H and notoincisols A–C (9–11), respectively.
Journal ArticleDOI

Evaluation of the anti-mycobacterium tuberculosis activity and in vivo acute toxicity of Annona sylvatic.

Rafaele Carla Pivetta de Araujo, +7 more
- 28 Jun 2014 - 
TL;DR: This is the first chemical characterization, antituberculosis activity and acute toxicity evaluation of Annona sylvatica, and among the compounds isolated, luteolin and almunequin were the most promising.
Journal ArticleDOI

Achillinin A, a cytotoxic guaianolide from the flower of Yarrow, Achillea millefolium.

Yong Li, +9 more
- 23 Aug 2011 - 
TL;DR: A new guaianolide isolated from the flower of Achillea millefolium exhibited potential antiproliferative activity to A549, RERF-LC-kj and QG-90 cells with 50% inhibitory concentration (IC50) values of 5.8, 10 and 0.31 μM, respectively.
Journal ArticleDOI

Antiproliferative Withanolides from Datura wrightii

Huaping Zhang, +9 more
- 22 Mar 2013 - 
TL;DR: A new withanolide, named withawrightolide (1), and four known withanolides (2-5) were isolated from the aerial parts of Datura wrightii and showed antiproliferative activities against human glioblastoma, head and neck squamous cell carcinoma, and normal fetal lung fibroblast cells with IC50 values in the range between 0.56 and 5.6 μM.
References
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Kinetic modeling on drug release from controlled drug delivery systems.

Suvakanta Dash, +3 more
- 01 May 2010 - 
TL;DR: The mathematical modeling can ultimately help to optimize the design of a therapeutic device to yield information on the efficacy of various release models.
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Fluorescent Sensors for Measuring Metal Ions in Living Systems

Kyle P. Carter, +2 more
- 03 Mar 2014 - 
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Dietary phenolics: chemistry, bioavailability and effects on health.

Alan Crozier, +2 more
- 22 Jul 2009 - 
TL;DR: This review summarizes the chemistry, biosynthesis and occurrence of the compounds involved, namely the C6-C3-C6 flavonoids-anthocyanins, dihydrochalcones, Flavan-3-ols, flavanones, flavones, Flavonols and isoflavones, and the mechanisms underlying these processes are discussed.
Journal ArticleDOI

Amide bond formation: beyond the myth of coupling reagents

Eric Valeur, +1 more
- 26 Jan 2009 - 
TL;DR: This critical review is focussed on the most recently developed coupling reagents with particular attention paid to the pros and cons of the plethora of "acronym" based reagents.
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Facile Discrimination of Aldose Enantiomers by Reversed-Phase HPLC

Takashi Tanaka, +4 more
- 01 Jun 2007 - 
TL;DR: The reaction was applied to the determination of absolute configuration the sugar residues of an aroma precursor and direct HPLC analysis of the reaction mixture and UV detection at 250 nm discriminated D- and L-enantiomers of aldoses.