Journal ArticleDOI
Chemical study and medical application of saponins as anti-cancer agents
TLDR
This article reviews many such structures and their related chemistry along with the recent advances in understanding mechanism of action and structure-function relationships of saponins at the molecular and cellular levels.About:
This article is published in Fitoterapia.The article was published on 2010-10-01. It has received 377 citations till now. The article focuses on the topics: Diosgenin.read more
Citations
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Journal ArticleDOI
Molecular activities, biosynthesis and evolution of triterpenoid saponins.
TL;DR: This review summarizes current knowledge of triterpenoid saponin biosynthesis in plants, molecular activities, evolutionary aspects and perspectives for further gene discovery.
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Cultivation, Genetic, Ethnopharmacology, Phytochemistry and Pharmacology of Moringa oleifera Leaves: An Overview
Alessandro Leone,Alberto Spada,Alberto Battezzati,Alberto Schiraldi,Junior Aristil,Simona Bertoli +5 more
TL;DR: It is suggested that a germplasm bank encompassing the genetic variability present in Moringa is needed to perform breeding programmes and develop elite varieties adapted to local conditions and further studies on humans are recommended.
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Metabolic and functional diversity of saponins, biosynthetic intermediates and semi-synthetic derivatives.
TL;DR: The industrial uses and potential of saponins are discussed with respect to structure and activity, highlighting the undoubted value of these molecules as therapeutics.
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Extraction and quantification of saponins: A review
TL;DR: A review of the saponin extraction with emphasis on conventional and green technology techniques employed in previous works by relating to their specific objective in each study to provide a point of reference to researchers who wish to design experiment to suit their particular objective in swift.
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The saponins: polar isoprenoids with important and diverse biological activities
TL;DR: This review will focus on the biological activity of some of the best-studied examples of saponins, on the relationship between structure and function, and on prospects for synthesis of ‘‘designer’’ saponin compounds.
References
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Biological activities and distribution of plant saponins.
TL;DR: Isolation studies of saponins were examined to determine which are the more commonly studied plant families and in which families saponin have been identified.
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Pharmacological and toxicological properties of Nigella sativa
Badreldin H. Ali,Gerald Blunden +1 more
TL;DR: The main reports of the pharmacological and toxicological properties of N. sativa and its constituents are reviewed, which include asthma, diarrhoea and dyslipidaemia.
Journal ArticleDOI
Saponins, classification and occurrence in the plant kingdom
TL;DR: The oleanane skeleton was the most common skeleton and is present in most orders of the plant kingdom, and the relationship between the type of skeleton and the plant origin was investigated.
Journal Article
Diosgenin, a steroid saponin of Trigonella foenum graecum (Fenugreek), inhibits azoxymethane-induced aberrant crypt foci formation in F344 rats and induces apoptosis in HT-29 human colon cancer cells
TL;DR: Results from the in vitro experiments indicated that diosgenin inhibits cell growth and induces apoptosis in the HT-29 human colon cancer cell line in a dose-dependent manner and seems to have potential as a novel colon cancer preventive agent.
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In vitro anti-cancer activity and structure-activity relationships of natural products isolated from fruits of Panax ginseng.
Wei Wang,Yuqing Zhao,Yuqing Zhao,Elizabeth R. Rayburn,Donald L. Hill,Hui Wang,Hui Wang,Ruiwen Zhang,Ruiwen Zhang +8 more
TL;DR: The results suggest that the type of dammarane, the number of sugar moieties, and differences in the substituent groups affect their anti-cancer activity.