Cholesterol efflux promoting function of high-density lipoproteins in calcific aortic valve stenosis
Duygu Kocyigit,Francesca Zimetti,Kadri Murat Gurses,Ilaria Zanotti,Cinzia Marchi,Marcus Ståhlman,Jan Borén,Hande Canpinar,Mehmet F. T. Soyal,Dicle Guc,Tuncay Hazirolan,Necla Ozer,Lale Tokgozoglu +12 more
- Vol. 44, pp 18-24
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Results indicate an impairment of HDL-CEC in moderate-severe CAVS and may contribute to identify potential novel targets for CAVS management.Abstract:
Background and aims Cholesterol efflux capacity is a functional property of high-density lipoproteins (HDL) reflecting the efficiency of the atheroprotective reverse cholesterol transport process in humans. Its relationship with calcific aortic valve stenosis (CAVS) has not been fully assessed yet. Methods We evaluated HDL-CEC in a patient population with varying degrees of aortic valvular calcific disease, assessed using echocardiography and cardiac computed tomography. Measurement of biomarkers that reflect osteogenic and tissue remodeling, along with dietary and gut microbiota-derived metabolites were performed. Results Patients with moderate-severe CAVS had significantly lower HDL-CEC compared to both control and aortic sclerosis subjects (mean: 6.09%, 7.32% and 7.26%, respectively). HDL-CEC displayed negative correlations with peak aortic jet velocity and aortic valve calcium score, indexes of CAVS severity (ρ = -0.298, p = 0.002 and ρ = -0.358, p = 0.005, respectively). In multivariable regression model, HDL-CEC had independent association with aortic valve calcium score (B: -0.053, SE: 0.014, p Conclusion These results indicate an impairment of HDL-CEC in moderate-severe CAVS and may contribute to identify potential novel targets for CAVS management.read more
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TL;DR: In this paper , the effects of high-density lipoprotein (HDL) particles isolated from the plasma of men and women with severe aortic stenosis were studied for cholesterol efflux capacity (CEC).
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Measures of high-density lipoprotein function in men and women with severe aortic stenosis
TL;DR: In this paper , the effects of high-density lipoprotein (HDL) particles isolated from the plasma of men and women with severe aortic stenosis were studied for cholesterol efflux capacity (CEC).
References
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Recommendations on the Echocardiographic Assessment of Aortic Valve Stenosis: A Focused Update from the European Association of Cardiovascular Imaging and the American Society of Echocardiography
Helmut Baumgartner,Judy Hung,Javier Bermejo,John B. Chambers,Thor Edvardsen,Steven A. Goldstein,Patrizio Lancellotti,Melissa LeFevre,Fletcher A. Miller,Catherine M Otto +9 more
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Suhny Abbara,Philipp Blanke,Christopher D. Maroules,Michael K. Cheezum,Andrew D. Choi,B. Kelly Han,Mohamed Marwan,Christopher Naoum,Bjarne L. Nørgaard,Ronen Rubinshtein,Paul Schoenhagen,Todd C. Villines,Jonathon Leipsic +12 more
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Roux-en-Y Gastric Bypass and Vertical Banded Gastroplasty Induce Long-Term Changes on the Human Gut Microbiome Contributing to Fat Mass Regulation
Valentina Tremaroli,Fredrik Karlsson,Malin Werling,Marcus Ståhlman,Petia Kovatcheva-Datchary,Torsten Olbers,Lars Fändriks,Carel W. le Roux,Carel W. le Roux,Jens Nielsen,Fredrik Bäckhed,Fredrik Bäckhed +11 more
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The Ability to Promote Efflux Via ABCA1 Determines the Capacity of Serum Specimens With Similar High-Density Lipoprotein Cholesterol to Remove Cholesterol From Macrophages
Margarita de la Llera-Moya,Denise Drazul-Schrader,Bela F. Asztalos,Marina Cuchel,Daniel J. Rader,George H. Rothblat +5 more
TL;DR: It is found that independently of HDL-C, sera with higher efflux capacity had a significant increase in ABCA1-mediated efflux, which was significantly correlated to the concentration of pre&bgr;-1 HDL.
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