Open AccessJournal Article
Chromosomal aberrations in lymphocytes predict human cancer independently of exposure to carcinogens
Stefano Bonassi,Lars Hagmar,Ulf Strömberg,Alicia Huici Montagud,Håkan Tinnerberg,Alessandra Forni,Pirjo Heikkilä,Saskia Wanders,Peter Wilhardt,Inger Lise Hansteen,Lisbeth E. Knudsen,Hannu Norppa +11 more
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TLDR
The risk for high versus low levels of CAs was similar in subjects heavily exposed to carcinogens and in those who had never, to their knowledge, been exposed to any major carcinogenic agent during their lifetime, supporting the idea that chromosome damage itself is involved in the pathway to cancer.Abstract:
An increased risk of cancer in healthy individuals with high levels of chromosomal aberrations (CAs) in peripheral blood lymphocytes has been described in recent epidemiological studies. This association did not appear to be modified by sex, age, country, or time since CA test, whereas the role played by exposure to carcinogens is still uncertain because of the requisite information concerning occupation and lifestyle was lacking. We evaluated in the present study whether CAs predicted cancer because they were the result of past exposure to carcinogens or because they were an intermediate end point in the pathway leading to disease. A nested case-control study was performed on 93 incident cancer cases and 62 deceased cancer cases coming from two prospective cohort studies performed in Nordic countries (Denmark, Finland, Norway, and Sweden) and Italy. For each case, four controls matched by country, sex, year of birth, and year of CA test were randomly selected. Occupational exposure and smoking habit were assessed by a collaborative group of occupational hygienists. Logistic regression models indicated a statistically significant increase in risk for subjects with a high level of CAs compared to those with a low level in the Nordic cohort (odds ratio, 2.35; 95% confidence interval, 1.31-4.23) and in the Italian cohort (odds ratio, 2.66; 95% confidence interval, 1.26-5.62). These estimates were not affected by the inclusion of occupational exposure level and smoking habit in the regression model. The risk for high versus low levels of CAs was similar in subjects heavily exposed to carcinogens and in those who had never, to their knowledge, been exposed to any major carcinogenic agent during their lifetime, supporting the idea that chromosome damage itself is involved in the pathway to cancer. The results have important ramifications for the understanding of the role played by sporadic chromosome damage for the origin of neoplasia-associated CAs.read more
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An increased micronucleus frequency in peripheral blood lymphocytes predicts the risk of cancer in humans.
Stefano Bonassi,Ariana Znaor,Marcello Ceppi,Cecilia Lando,Wushou P. Chang,Nina Holland,Micheline Kirsch-Volders,Errol Zeiger,Sadayuki Ban,Sadayuki Ban,Roberto Barale,Maria Paola Bigatti,Claudia Bolognesi,Antonina Cebulska-Wasilewska,Eleonora Fabianova,Alexandra Fucic,Lars Hagmar,Gordana Joksić,Antonietta Martelli,Lucia Migliore,Ekaterina Mirkova,Maria Rosaria Scarfì,Andrea Zijno,Hannu Norppa,Michael Fenech +24 more
TL;DR: Preliminary evidence is provided that MN frequency in PBL is a predictive biomarker of cancer risk within a population of healthy subjects and in all national cohorts and for all major cancer sites.
Journal ArticleDOI
Cancer epidemiology in the last century and the next decade
TL;DR: The remarkable advances in cell and molecular biology over the past two decades have transformed the scope and methods of cancer epidemiology, and modern epidemiological studies often depend on genetic, biochemical or viral assays that had not been developed 20 years ago.
Journal ArticleDOI
DNA damage from micronutrient deficiencies is likely to be a major cause of cancer.
TL;DR: Micronutrient deficiency may explain why the quarter of the population that eats the fewest fruits and vegetables has about double the cancer rate for most types of cancer when compared to the quarter with the highest intake.
Journal ArticleDOI
The micronucleus assay in human buccal cells as a tool for biomonitoring DNA damage: The HUMN project perspective on current status and knowledge gaps
Nina Holland,Claudia Bolognesi,Micheline Kirsch-Volders,Stefano Bonassi,Errol Zeiger,Siegfried Knasmueller,Michael Fenech +6 more
TL;DR: The harmonization and standardization of the buccal MN assay will allow more reliable comparison of the data among human populations and laboratories, evaluation of the assay's performance, and consolidation of its world-wide use for biomonitoring of DNA damage.
Journal ArticleDOI
The role of folic acid and Vitamin B12 in genomic stability of human cells.
TL;DR: Dietary intakes above the current RDI may be particularly important in those with extreme defects in the absorption and metabolism of these Vitamins, for which ageing is a contributing factor.
References
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Book
Applied Logistic Regression
David W. Hosmer,Stanley Lemeshow +1 more
TL;DR: Hosmer and Lemeshow as discussed by the authors provide an accessible introduction to the logistic regression model while incorporating advances of the last decade, including a variety of software packages for the analysis of data sets.
Journal ArticleDOI
Applied Logistic Regression.
TL;DR: Applied Logistic Regression, Third Edition provides an easily accessible introduction to the logistic regression model and highlights the power of this model by examining the relationship between a dichotomous outcome and a set of covariables.
Journal Article
An international system for human cytogenetic nomenclature
TL;DR: An exceptional reading e-book entitled International System For Human Cytogenetic Nomenclature provides a thorough legal analysis and guidance to state authorities, human rights and humanitarian actors and others.
Journal ArticleDOI
Genetic instabilities in human cancers
TL;DR: There is now evidence that most cancers may indeed be genetically unstable, but that the instability exists at two distinct levels, and recognition and comparison of these instabilities are leading to new insights into tumour pathogenesis.
Journal ArticleDOI
Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: Implications for cancer and neuronal damage
Benjamin C. Blount,Matthew M. Mack,Carol M. Wehr,James T. MacGregor,Robert A. Hiatt,Gene Wang,Sunitha N. Wickramasinghe,Richard B. Everson,Bruce N. Ames +8 more
TL;DR: Both high DNA uracil levels and elevated micronucleus frequency (a measure of chromosome breaks) are reversed by folate administration, which could contribute to the increased risk of cancer and cognitive defects associated with folate deficiency in humans.
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An increased micronucleus frequency in peripheral blood lymphocytes predicts the risk of cancer in humans.
Stefano Bonassi,Ariana Znaor,Marcello Ceppi,Cecilia Lando,Wushou P. Chang,Nina Holland,Micheline Kirsch-Volders,Errol Zeiger,Sadayuki Ban,Sadayuki Ban,Roberto Barale,Maria Paola Bigatti,Claudia Bolognesi,Antonina Cebulska-Wasilewska,Eleonora Fabianova,Alexandra Fucic,Lars Hagmar,Gordana Joksić,Antonietta Martelli,Lucia Migliore,Ekaterina Mirkova,Maria Rosaria Scarfì,Andrea Zijno,Hannu Norppa,Michael Fenech +24 more