Chromosome Organization in Early Meiotic Prophase.
Corinne Grey,Bernard de Massy +1 more
TLDR
In this article, the axial elements are used to set the stage for efficient sister chromatid cohesion and meiotic recombination, necessary for the recognition of the homologous chromosomes.Abstract:
One of the most fascinating aspects of meiosis is the extensive reorganization of the genome at the prophase of the first meiotic division (prophase I). The first steps of this reorganization are observed with the establishment of an axis structure, that connects sister chromatids, from which emanate arrays of chromatin loops. This axis structure, called the axial element, consists of various proteins, such as cohesins, HORMA-domain proteins, and axial element proteins. In many organisms, axial elements are required to set the stage for efficient sister chromatid cohesion and meiotic recombination, necessary for the recognition of the homologous chromosomes. Here, we review the different actors involved in axial element formation in Saccharomyces cerevisiae and in mouse. We describe the current knowledge of their localization pattern during prophase I, their functional interdependence, their role in sister chromatid cohesion, loop axis formation, homolog pairing before meiotic recombination, and recombination. We also address further challenges that need to be resolved, to fully understand the interplay between the chromosome structure and the different molecular steps that take place in early prophase I, which lead to the successful outcome of meiosis I.read more
Citations
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Meiotic recombination: insights into its mechanisms and its role in human reproduction with a special focus on non-obstructive azoospermia.
TL;DR: The cumulative results suggest that variants of meiotic recombination-related genes can cause human subfertility or infertility, especially NOA, and should be avoided when an NOA-affected individual carries definite disease-causing mutations of a meiotic gene.
Journal ArticleDOI
OUP accepted manuscript
TL;DR: In this article , the molecular mechanisms of meiotic recombination and related human infertility disorders, particularly male infertility caused by non-obstructive azoospermia (NOA), were investigated.
Journal ArticleDOI
Rec8 Cohesin: A Structural Platform for Shaping the Meiotic Chromosomes
Takeshi Sakuno,Yasushi Hiraoka +1 more
TL;DR: The current understanding of Rec8 cohesin as a structural platform for meiotic chromosomes is reviewed, which indicates its function in modulating chromosomal architecture during the pairing and recombination of homologous chromosomes in meiosis.
Journal ArticleDOI
SCF ubiquitin E3 ligase regulates DNA double-strand breaks in early meiotic recombination
TL;DR: The results support a model wherein the SCF ubiquitin E3 ligase prevents hyperactive DSB formation through proteasome-mediated degradation of HORMAD1 and subsequent modulation of the pre-DSB complex during meiosis.
Journal ArticleDOI
OUP accepted manuscript
TL;DR: In this paper , SKP1, a constitutive subunit of the SCF ubiquitin E3 ligase, was shown to be crucial for sister chromatid cohesion during the pre-meiotic S-phase.
References
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Journal ArticleDOI
Formation of Chromosomal Domains by Loop Extrusion
Geoffrey Fudenberg,Maxim Imakaev,Carolyn Lu,Anton Goloborodko,Nezar Abdennur,Leonid A. Mirny,Leonid A. Mirny +6 more
TL;DR: This model produces TADs and finer-scale features of Hi-C data because each TAD emerges from multiple loops dynamically formed through extrusion, contrary to typical illustrations of single static loops.
Journal ArticleDOI
Meiotic chromosomes: integrating structure and function.
Denise Zickler,Nancy Kleckner +1 more
TL;DR: The current article reviews recent information on diverse aspects of chromosome morphogenesis, notably relationships between sisters, development of axial structure, and variations in chromatin status in an historical context.
Journal ArticleDOI
Recombinational DNA double-strand breaks in mice precede synapsis
Shantha K. Mahadevaiah,James M. A. Turner,Frédéric Baudat,Emmy P. Rogakou,Peter Boer,Josefa Blanco-Rodríguez,Maria Jasin,Scott Keeney,William M. Bonner,Paul S. Burgoyne +9 more
TL;DR: It is shown that, as in yeast, recombination in the mouse is initiated by Spo11-dependent DSBs that form during leptotene, and loss of γ-H2AX staining is temporally and spatially correlated with synapsis, even when thissynapsis is 'non-homologous'.
Journal ArticleDOI
Organization and function of the 3D genome.
TL;DR: The insights into chromatin architecture that have been gained through recent technological developments in quantitative biology, genomics and cell and molecular biology approaches are discussed and how these new concepts have been used to address important biological questions in development and disease are explained.
Journal ArticleDOI
A central role for cohesins in sister chromatid cohesion, formation of axial elements, and recombination during yeast meiosis.
Franz Klein,Peter Mahr,Marta Galova,Sara B.C. Buonomo,Christine Michaelis,Knud Nairz,Kim Nasmyth +6 more
TL;DR: It is shown that Smc3p and a meiotic version of Scc1p called Rec8p are required for cohesion between sister chromatids, for formation of axial elements, for reciprocal recombination, and for preventing hyperresection of double-strand breaks during meiosis.
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