Circadian Clock and Breast Cancer: A Molecular Link
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TLDR
This work speculates on the molecular pathways that may couple the circadian machinery to breast cancer.Abstract:
The circadian clock controls a large array of behavioral and physiological systems of fundamental importance to most organisms. Consequently, abnormal functioning of the clock results in severe dysfunctions and pathologies. Although epidemiological studies show a clear correlation between disruption of circadian rhythms and incidence of breast cancer, a molecular interpretation of how clock-related mechanisms may link to tumor development remains elusive. Here we speculate on the molecular pathways that may couple the circadian machinery to breast cancer.read more
Citations
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Metabolism and cancer: the circadian clock connection
TL;DR: Connections between the circadian clock and cellular metabolism have been identified that are regulated by chromatin remodelling, suggesting that abnormal metabolism in cancer could also be a consequence of a disrupted circadian clock.
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TL;DR: Current evidence indicates that lifestyle factors might affect human health via epigenetic mechanisms, such as DNA methylation, histone acetylation and miRNA expression.
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Melatonin, the circadian multioscillator system and health: the need for detailed analyses of peripheral melatonin signaling.
TL;DR: It is an aim of this review to stimulate research on melatonin signaling in peripheral tissues and discriminate between direct effects of the pineal indoleamine at the target organ and others mediated by modulation of oscillators.
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Considerations of circadian impact for defining 'shift work' in cancer studies: IARC working group report
Richard G. Stevens,Johnni Hansen,Giovanni Costa,Erhard Haus,Timo Kauppinen,Kristan J. Aronson,Gemma Castaño-Vinyals,Scott Davis,Monique H. W. Frings-Dresen,Lin Fritschi,Manolis Kogevinas,Kazutaka Kogi,Jenny Anne S. Lie,Arne Lowden,Beata Peplonska,Beate Pesch,Eero Pukkala,Eva S. Schernhammer,Ruth C. Travis,Roel Vermeulen,Tongzhang Zheng,Vincent Cogliano,Kurt Straif +22 more
TL;DR: It is recognised that for further domains of non-day shifts and shift schedules to be identified, more research needs to be conducted on the impact of various shift schedules and routines on physiological and circadian rhythms of workers in real-world environments.
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Light-at-night, circadian disruption and breast cancer: assessment of existing evidence
TL;DR: If a consensus eventually emerges that LAN does increase risk, then the mechanisms for the effect are important to elucidate for intervention and mitigation and will provide for the development of lighting technologies at home and at work that minimize circadian disruption, while maintaining visual efficiency and aesthetics.
References
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