Clinical and Preclinical Evidence for Functional Interactions of Cannabidiol and Δ9-Tetrahydrocannabinol.
TLDR
Future cannabis-related policy decisions should include consideration of scientific findings, including the individual and interactive effects of CBD and THC, as well as other cannabinoid molecules currently being evaluated for medicinal purposes, separately and in combination.About:
This article is published in Neuropsychopharmacology.The article was published on 2018-01-01 and is currently open access. It has received 164 citations till now. The article focuses on the topics: Effects of cannabis & Cannabis.read more
Citations
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New trends in cannabis potency in USA and Europe during the last decade (2008-2017).
Suman Chandra,Mohamed M. Radwan,Chandrani G. Majumdar,James C. Church,Tom P. Freeman,Tom P. Freeman,Mahmoud A. ElSohly +6 more
TL;DR: The results showed that the mean Δ9-THC concentration has increased dramatically over the last 10 years, and trends in the last decade suggest that cannabis is becoming an increasingly harmful product in the USA and Europe.
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Cannabidiol (CBD) content in vaporized cannabis does not prevent tetrahydrocannabinol (THC)-induced impairment of driving and cognition
Thomas R. Arkell,Nicholas Lintzeris,Richard C. Kevin,Johannes G. Ramaekers,Ryan Vandrey,Christopher Irwin,Paul S. Haber,Paul S. Haber,Iain S. McGregor +8 more
TL;DR: Cannabis containing equivalent concentrations of CBD and THC appears no less impairing than THC-dominant cannabis, and in some circumstances, CBD may actually exacerbate THC-induced impairment.
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Review of the Endocannabinoid System
Hui-Chen Lu,Ken Mackie +1 more
TL;DR: This review discusses how phytocannabinoids and other exogenous compounds may perturb the ECS, emphasizing examples relevant to psychosis and a description of ECS components and their role in synaptic plasticity and neurodevelopment.
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Cannabidiol and other non-psychoactive cannabinoids for prevention and treatment of gastrointestinal disorders: Useful nutraceuticals?
Vicente Martinez,Vicente Martinez,Amaia Iriondo De-Hond,Francesca Borrelli,Raffaele Capasso,María Dolores del Castillo,Raquel Abalo,Raquel Abalo +7 more
TL;DR: The hemp plant is looked at as a possible source of new functional food ingredients and nutraceuticals that might be eventually useful to treat or even prevent gastrointestinal conditions and the available data showing that non-psychoactive phytocannabinoids, particularly cannabidiol, may be useful to treatment different disorders and diseases of the gastrointestinal tract are revised.
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Corrigendum: Potential Clinical Benefits of CBD-Rich Cannabis Extracts Over Purified CBD in Treatment-Resistant Epilepsy: Observational Data Meta-analysis.
TL;DR: CBD-rich extracts seem to present a better therapeutic profile than purified CBD, at least in this population of patients with refractory epilepsy, but this remains to be confirmed in controlled clinical studies.
References
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Isolation and structure of a brain constituent that binds to the cannabinoid receptor
William A. Devane,Lumir Hanus,Aviva Breuer,Roger G. Pertwee,Lesley A. Stevenson,Graeme Griffin,Dan Gibson,Asher Mandelbaum,A. Etinger,Raphael Mechoulam +9 more
TL;DR: In this article, an arachidonylethanthanolamide (anandamide) was identified in a screen for endogenous ligands for the cannabinoid receptor and its structure was determined by mass spectrometry and nuclear magnetic resonance spectroscopy and confirmed by synthesis.
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Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors.
Raphael Mechoulam,Shimon Ben-Shabat,Lumir Hanus,Moshe Ligumsky,Norbert E. Kaminski,Anthony R. Schatz,Asher Gopher,Shlomo Almog,Billy R. Martin,David R. Compton,Roger G. Pertwee,Graeme Griffin,Michael Bayewitch,Jacob Barg,Zvi Vogel +14 more
TL;DR: Upon intravenous administration to mice, 2-Ara-Gl caused the typical tetrad of effects produced by THC: antinociception, immobility, reduction of spontaneous activity, and lowering of the rectal temperature.
Journal Article
Determination and characterization of a cannabinoid receptor in rat brain.
TL;DR: The criteria for a high affinity, stereoselective, pharmacologically distinct cannabinoid receptor in brain tissue have been fulfilled.
Journal ArticleDOI
Isolation, Structure, and Partial Synthesis of an Active Constituent of Hashish
Y. Gaoni,Raphael Mechoulam +1 more
TL;DR: In this paper, the extinction coefficients of stilbene, stil bene-, and stilben-2 were determined for tetrahydrofuran, 2-methyltetrahydrlfurfh-fragments, and 1,2-dime thoxye thane.
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2-Arachidonoylgylcerol: A Possible Endogenous Cannabinoid Receptor Ligand in Brain
Takayuki Sugiura,Sachiko Kondo,Akihiro Sukagawa,Shinji Nakane,A. Shinoda,K. Itoh,Atsushi Yamashita,Keizo Waku +7 more
TL;DR: 2-Arachidonoylglycerol was shown to bind appreciably to the cannabinoid receptor in competitive inhibition experiments and may be an endogenous cannabinoid receptor ligand in the brain.