Clinical Pharmacogenetics Implementation Consortium Guidelines for CYP2C19 Genotype and Clopidogrel Therapy: 2013 Update
Stuart A. Scott,Katrin Sangkuhl,Charles M. Stein,Jean-Sébastien Hulot,Jean-Sébastien Hulot,Jessica L. Mega,Dan M. Roden,Teri E. Klein,Marc S. Sabatine,Julie A. Johnson,Julie A. Johnson,Alan R. Shuldiner,Alan R. Shuldiner +12 more
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TLDR
In this article, an expanded literature review showed that CYP2C19 loss-of-function alleles confer increased risks for serious adverse cardiovascular (CV) events among clopidogrel-treated patients with acute coronary syndromes (ACSs) undergoing percutaneous coronary intervention (PCI).Abstract:
Cytochrome P450 (CYP)2C19 catalyzes the bioactivation of the antiplatelet prodrug clopidogrel, and CYP2C19 loss-of-function alleles impair formation of active metabolites, resulting in reduced platelet inhibition. In addition, CYP2C19 loss-of-function alleles confer increased risks for serious adverse cardiovascular (CV) events among clopidogrel-treated patients with acute coronary syndromes (ACSs) undergoing percutaneous coronary intervention (PCI). Guideline updates include emphasis on appropriate indication for CYP2C19 genotype–directed antiplatelet therapy, refined recommendations for specific CYP2C19 alleles, and additional evidence from an expanded literature review (updates at http://www.pharmgkb.org).read more
Citations
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Journal ArticleDOI
Influence of CYP2C19 Phenotype on the Effect of Clopidogrel in Patients Undergoing a Percutaneous Neurointervention Procedure
Miriam Saiz-Rodríguez,Daniel Romero-Palacián,Carlos Villalobos-Vilda,José Luis Caniego,Carmen Belmonte,Dora Koller,Eduardo Bárcena,María Talegón,Francisco Abad-Santos,Francisco Abad-Santos +9 more
TL;DR: The antiplatelet response and clinical events after clopidogrel treatment in patients who underwent percutaneous neurointervention, related to CYP2C19 metabolizer status (normal), intermediate/poor (IM‐PM), and ultrarapid (UM); inferred from *2, *3, and *17 allele determination.
Journal ArticleDOI
Clopidogrel-associated genetic variants on inhibition of platelet activity and clinical outcome for acute coronary syndrome patients.
TL;DR: The aim of this study is to unravel the effect of clopidogrel‐associated genetic variants on inhibition of platelet activity and clinical outcomes in ACS patients.
Journal ArticleDOI
Feasibility and implementation of CYP2C19 genotyping in patients using antiplatelet therapy.
Thomas O. Bergmeijer,Gerrit J.A. Vos,Daniel M.F. Claassens,Paul Wa Janssen,Remko Harms,Richard van der Heide,Folkert W. Asselbergs,Jurriën M. ten Berg,Vera H.M. Deneer +8 more
TL;DR: CYP2C19 genotyping is feasible in everyday clinical practice, both in the acute and non-acute settings, and may reduce atherothrombotic and bleeding events.
Journal ArticleDOI
Dutch Pharmacogenetics Working Group (DPWG) guideline for the gene-drug interaction between CYP2C19 and CYP2D6 and SSRIs.
Jurriaan M. J. L. Brouwer,Jurriaan M. J. L. Brouwer,Marga Nijenhuis,Bianca Soree,Henk-Jan Guchelaar,Jesse J. Swen,Ron H.N. van Schaik,Jan van der Weide,Gerard A. Rongen,Anne-Marie Buunk,Nienke J de Boer-Veger,Elisa J. F. Houwink,Roos van Westrhenen,Roos van Westrhenen,Bob Wilffert,Vera H.M. Deneer,Vera H.M. Deneer,Hans Mulder +17 more
TL;DR: The Dutch Pharmacogenetics Working Group (DPWG) guideline as mentioned in this paper presents the gene-drug interaction between the genes CYP2C19 and CYP 2D6 and antidepressants of the selective serotonin reuptake inhibitor type (SSRIs).
Journal ArticleDOI
Genotype-guided antiplatelet therapy compared with conventional therapy for patients with acute coronary syndromes: a systematic review and meta-analysis.
TL;DR: Genotype-guided strategies could reduce the rates of cardiovascular events without increasing bleeding events compared with conventional treatment in ACS and future multi-centre genotype-based randomized control trials are required to confirm these findings.
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