Clinical Pharmacogenetics Implementation Consortium Guidelines for CYP2C19 Genotype and Clopidogrel Therapy: 2013 Update
Stuart A. Scott,Katrin Sangkuhl,Charles M. Stein,Jean-Sébastien Hulot,Jean-Sébastien Hulot,Jessica L. Mega,Dan M. Roden,Teri E. Klein,Marc S. Sabatine,Julie A. Johnson,Julie A. Johnson,Alan R. Shuldiner,Alan R. Shuldiner +12 more
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TLDR
In this article, an expanded literature review showed that CYP2C19 loss-of-function alleles confer increased risks for serious adverse cardiovascular (CV) events among clopidogrel-treated patients with acute coronary syndromes (ACSs) undergoing percutaneous coronary intervention (PCI).Abstract:
Cytochrome P450 (CYP)2C19 catalyzes the bioactivation of the antiplatelet prodrug clopidogrel, and CYP2C19 loss-of-function alleles impair formation of active metabolites, resulting in reduced platelet inhibition. In addition, CYP2C19 loss-of-function alleles confer increased risks for serious adverse cardiovascular (CV) events among clopidogrel-treated patients with acute coronary syndromes (ACSs) undergoing percutaneous coronary intervention (PCI). Guideline updates include emphasis on appropriate indication for CYP2C19 genotype–directed antiplatelet therapy, refined recommendations for specific CYP2C19 alleles, and additional evidence from an expanded literature review (updates at http://www.pharmgkb.org).read more
Citations
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The ChinaMAP analytics of deep whole genome sequences in 10,588 individuals.
Yanan Cao,Lin Li,Min Xu,Zhimin Feng,Xiaohui Sun,Jieli Lu,Yu Xu,Peina Du,Tiange Wang,Ruying Hu,Zhen Ye,Lixin Shi,Xulei Tang,Li Yan,Zhengnan Gao,Gang Chen,Yinfei Zhang,Lulu Chen,Guang Ning,Yufang Bi,Weiqing Wang +20 more
TL;DR: This study establishes a large-scale and deep resource for the genetics of East Asians and provides opportunities for novel genetic discoveries of metabolic characteristics and disorders.
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Recommendations for Clinical CYP2C19 Genotyping Allele Selection: A Report of the Association for Molecular Pathology.
Victoria M. Pratt,Andria L. Del Tredici,Houda Hachad,Yuan Ji,Lisa V. Kalman,Stuart A. Scott,Stuart A. Scott,Karen E. Weck +7 more
TL;DR: In this article, the Association for Molecular Pathology (PGx) working group developed a set of recommendations for PGx genotyping assays, including a minimum panel of variant alleles and an extended panel of variants.
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The East Asian Paradox: An Updated Position Statement on the Challenges to the Current Antithrombotic Strategy in Patients with Cardiovascular Disease
Hyun Kuk Kim,Udaya S. Tantry,Sidney C. Smith,Myung Ho Jeong,Seung-Jung Park,Moo Hyun Kim,Do Sun Lim,Eun-Seok Shin,Duk-Woo Park,Yong Huo,Shao-Liang Chen,Zheng Bo,Shinya Goto,Takeshi Kimura,Satoshi Yasuda,Wen Jone Chen,Mark Y. Chan,Daniel Aradi,Tobias Geisler,Diana A. Gorog,Diana A. Gorog,Dirk Sibbing,Gregory Y.H. Lip,Dominick J. Angiolillo,Paul A. Gurbel,Young-Hoon Jeong +25 more
TL;DR: New evidence and future directions of antithrombotic treatment in East Asian patients are proposed and the unique risk-benefit trade-off in East Asians is proposed.
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Genetic variation in the human cytochrome P450 supergene family
TL;DR: The results suggest that the variant spectrum of human CYP genes is extensive and only a fraction of SNVs has been characterized to date, and the multitude of very rare novel sequence variants indicates that the commonly used SNV platforms are not satisfactory for determining the true genotype.
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The effect of pharmacogenetic profiling with a clinical decision support tool on healthcare resource utilization and estimated costs in the elderly exposed to polypharmacy.
Diana I. Brixner,Eman Biltaji,Adam P. Bress,Sudhir Unni,Xiangyang Ye,T Mamiya,K. Ashcraft,J. Biskupiak +7 more
TL;DR: Patients CYP DNA tested and treated according to the personalized prescribing system had a significant decrease in hospitalizations and emergency department visits, resulting in potential cost savings.
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