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Clonal evolution in cancer
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The article was published on 2010-01-01 and is currently open access. It has received 817 citations till now. The article focuses on the topics: Somatic evolution in cancer & Cancer.read more
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Università degli Studi di Ferrara DOTTORATO DI RICERCA IN FARMACOLOGIA ED ONCOLOGIA MOLECOLARE
TL;DR: The nuclear PKCζ-inhibitor reverts the apoptotic effect of Doxorubicin in chemotherapeuticresistant cells and the adipogenic differentiation of muscle-derived stem cells is reversed.
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Resistance Development: A Major Piece in the Jigsaw Puzzle of Tumor Size Modeling
TL;DR: A general framework for developing future semi‐mechanistic TS/TGI models of drug resistance is proposed, which can foster the incorporation of new mechanistic aspects into modeling approaches, improving anticancer drug effect prediction.
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Enhancing cancer clonality analysis with integrative genomics
Erich A. Peterson,Michael A Bauer,Shweta S. Chavan,Cody Ashby,Niels Weinhold,Christoph Heuck,Gareth J. Morgan,Donald J. Johann +7 more
TL;DR: The iCloneViz approach can be used for analysis of clonal evolution and mutational dynamics of multi-omic data sets and facilitates improved mutational characterization, understanding, and therapeutic assignments.
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Protein-based identification of quantitative trait loci associated with malignant transformation in two HER2+ cellular models of breast cancer
Yogesh Kulkarni,David J. Klinke +1 more
TL;DR: While "protein ubiquitination" and "apoptosis signaling" pathways were common to both the cell lines, the observed patterns of protein expression suggest that the evasion of apoptosis in each tumorigenic cell line occurs via different mechanisms.
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Stem cell technology in breast cancer: current status and potential applications.
TL;DR: This review will specifically emphasize on the therapeutic use of naïve or engineered normal stem cells in the treatment of breast cancer and present contradictory findings challenging their safety.
References
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Journal ArticleDOI
Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics
Andrea Sottoriva,Andrea Sottoriva,Andrea Sottoriva,Inmaculada Spiteri,Sara Grazia Maria Piccirillo,Anestis Touloumis,V. Peter Collins,John C. Marioni,Christina Curtis,Colin Watts,Simon Tavaré,Simon Tavaré,Simon Tavaré +12 more
TL;DR: The genome-wide architecture of intratumor variability in GB is revealed across multiple spatial scales and patient-specific patterns of cancer evolution, with consequences for treatment design.
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Metastatic colonization by circulating tumour cells
TL;DR: An improved understanding of the mechanistic determinants of such colonization is needed to better prevent and treat metastatic cancer.
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Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia
Liran I. Shlush,Sasan Zandi,Amanda Mitchell,Weihsu Claire Chen,Joseph M. Brandwein,Vikas Gupta,James A. Kennedy,Aaron D. Schimmer,Andre C. Schuh,Karen W.L. Yee,Jessica McLeod,Monica Doedens,Jessie J. F. Medeiros,Rene Marke,Hyeoung Joon Kim,Kwon Lee,John Douglas Mcpherson,Thomas J. Hudson,Andrew M.K. Brown,Fouad Yousif,Quang M. Trinh,Lincoln Stein,Mark D. Minden,Jean C.Y. Wang,John E. Dick +24 more
TL;DR: Highly purified haematopoietic stem cells, progenitor and mature cell fractions from the blood of AML patients were found to contain recurrent DNMT3A mutations at high allele frequency, but without coincident NPM1 mutations (NPM1c) present in AML blasts.
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The evolutionary history of lethal metastatic prostate cancer.
Gunes Gundem,Peter Van Loo,Peter Van Loo,Peter Van Loo,Barbara Kremeyer,Ludmil B. Alexandrov,Jose M. C. Tubio,Elli Papaemmanuil,Daniel Brewer,Heini Kallio,Gunilla Högnäs,Matti Annala,Kati Kivinummi,Victoria Goody,Calli Latimer,Sarah O’Meara,Kevin J. Dawson,William B. Isaacs,Michael R. Emmert-Buck,Matti Nykter,Christopher S. Foster,Zsofia Kote-Jarai,Douglas F. Easton,Hayley C. Whitaker,David E. Neal,Colin Cooper,Colin Cooper,Rosalind A. Eeles,Rosalind A. Eeles,Tapio Visakorpi,Peter J. Campbell,Ultan McDermott,David C. Wedge,G. Steven Bova +33 more
TL;DR: In this article, the existence of polyclonal seeding in human malignancy and the clonal relationship among different metastases in the context of androgen-deprived metastatic prostate cancer was established.
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Clonal evolution in breast cancer revealed by single nucleus genome sequencing
Yong Wang,Jill Waters,Marco L. Leung,Anna K. Unruh,Whijae Roh,Xiuqing Shi,Ken Chen,Paul Scheet,Selina Vattathil,Han Liang,Asha S. Multani,Hong Zhang,Rui Zhao,Franziska Michor,Funda Meric-Bernstam,Nicholas Navin +15 more
TL;DR: The data show that aneuploid rearrangements occurred early in tumour evolution and remained highly stable as the tumour masses clonally expanded, which has important implications for the diagnosis, therapeutic treatment and evolution of chemoresistance in breast cancer.