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Clonal evolution in cancer
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The article was published on 2010-01-01 and is currently open access. It has received 817 citations till now. The article focuses on the topics: Somatic evolution in cancer & Cancer.read more
Citations
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Journal ArticleDOI
Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics
Andrea Sottoriva,Andrea Sottoriva,Andrea Sottoriva,Inmaculada Spiteri,Sara Grazia Maria Piccirillo,Anestis Touloumis,V. Peter Collins,John C. Marioni,Christina Curtis,Colin Watts,Simon Tavaré,Simon Tavaré,Simon Tavaré +12 more
TL;DR: The genome-wide architecture of intratumor variability in GB is revealed across multiple spatial scales and patient-specific patterns of cancer evolution, with consequences for treatment design.
Journal ArticleDOI
Metastatic colonization by circulating tumour cells
TL;DR: An improved understanding of the mechanistic determinants of such colonization is needed to better prevent and treat metastatic cancer.
Journal ArticleDOI
Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia
Liran I. Shlush,Sasan Zandi,Amanda Mitchell,Weihsu Claire Chen,Joseph M. Brandwein,Vikas Gupta,James A. Kennedy,Aaron D. Schimmer,Andre C. Schuh,Karen W.L. Yee,Jessica McLeod,Monica Doedens,Jessie J. F. Medeiros,Rene Marke,Hyeoung Joon Kim,Kwon Lee,John Douglas Mcpherson,Thomas J. Hudson,Andrew M.K. Brown,Fouad Yousif,Quang M. Trinh,Lincoln Stein,Mark D. Minden,Jean C.Y. Wang,John E. Dick +24 more
TL;DR: Highly purified haematopoietic stem cells, progenitor and mature cell fractions from the blood of AML patients were found to contain recurrent DNMT3A mutations at high allele frequency, but without coincident NPM1 mutations (NPM1c) present in AML blasts.
Journal Article
The evolutionary history of lethal metastatic prostate cancer
Gunes Gundem,P Van Loo,Barbara Kremeyer,Ludmil B. Alexandrov,Tubio Jmc.,Elli Papaemmanuil,Daniel Brewer,Heini Kallio,Gunilla Högnäs,Matti Annala,Kati Kivinummi,Victoria Goody,Calli Latimer,Sarah O’Meara,Kevin J. Dawson,William B. Isaacs,Michael R. Emmert-Buck,Matti Nykter,Claire Foster,Z Kote-Jarai,Doug Easton,Hayley C. Whitaker,David E. Neal,Colin Cooper,Rosalind A. Eeles,Tapio Visakorpi,Peter J. Campbell,Ultan McDermott,David C. Wedge,G S Bova +29 more
TL;DR: Using whole-genome sequencing, multiple metastases arising from prostate tumours in ten patients are characterized and the complex patterns of metastatic spread are elucidate in detail and the development of resistance to androgen-deprivation therapy in prostate cancer is understood.
Journal ArticleDOI
Clonal evolution in breast cancer revealed by single nucleus genome sequencing
Yong Wang,Jill Waters,Marco L. Leung,Anna K. Unruh,Whijae Roh,Xiuqing Shi,Ken Chen,Paul Scheet,Selina Vattathil,Han Liang,Asha S. Multani,Hong Zhang,Rui Zhao,Franziska Michor,Funda Meric-Bernstam,Nicholas Navin +15 more
TL;DR: The data show that aneuploid rearrangements occurred early in tumour evolution and remained highly stable as the tumour masses clonally expanded, which has important implications for the diagnosis, therapeutic treatment and evolution of chemoresistance in breast cancer.
References
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Oncolytic Virotherapy versus Cancer Stem Cells: A Review of Approaches and Mechanisms
TL;DR: The mechanism through which CSCs can escape conventional therapies and how they may still be susceptible to different classes of oncolytic viruses is discussed.
Journal ArticleDOI
Combination of Ponatinib with Hedgehog Antagonist Vismodegib for Therapy-Resistant BCR-ABL1–Positive Leukemia
Seiichiiro Katagiri,Tetsuzo Tauchi,Seiichi Okabe,Yosuke Minami,Shinya Kimura,Taira Maekawa,Tomoki Naoe,Kazuma Ohyashiki +7 more
TL;DR: The preclinical results indicate that vismodegib has potential as an important option for controlling minimal residual cells in BCR-ABL1–positive leukemia, and the combination with a Smo inhibitor and ABL1 tyrosine kinase inhibitors may help eliminate therapy-resistant T315I B CR-ABl1– positive leukemia cells.
Journal ArticleDOI
Cancer stem cells display extremely large evolvability: alternating plastic and rigid networks as a potential mechanism
Peter Csermely,Janos Hodsagi,Tamas Korcsmaros,Dezső Módos,Aron R. Perez-Lopez,Kristof Z. Szalay,Daniel V. Veres,Katalin Lenti,Ling-Yun Wu,Xiang-Sun Zhang +9 more
TL;DR: In this article, a two-phase process of malignant transformation is described, where an initial increase of network plasticity is followed by a decrease of plasticity at late stages of tumor development.
Journal ArticleDOI
Treatment resistance in urothelial carcinoma: an evolutionary perspective
TL;DR: The molecular basis of the clonal evolution of urothelial carcinomas and the use of genomic approaches to predict treatment responses are described and various mechanisms of resistance to chemotherapy are discussed, with a focus on the mutagenic effects of the DNA dC->dU-editing enzymes APOBEC3 family of proteins.
Journal ArticleDOI
ANKRD22 promotes progression of non-small cell lung cancer through transcriptional up-regulation of E2F1
TL;DR: It is suggested that ANKRD22 could potentially act as a novel therapeutic target for NSCLC by enhancing cell proliferation and up-regulating the expression of E2F1 which enhanced cell cycle progression.