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Clonal evolution in cancer
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The article was published on 2010-01-01 and is currently open access. It has received 817 citations till now. The article focuses on the topics: Somatic evolution in cancer & Cancer.read more
Citations
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Cancer stem cells, cancer cell plasticity and radiation therapy.
Erina Vlashi,Frank Pajonk +1 more
TL;DR: Evidence is provided supporting the idea that non-stem cancer cells exhibit a remarkable degree of plasticity that allows them to re-acquire cancer stem cell traits, especially in the context of radiation therapy.
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Pancreatic Cancer Metastases Harbor Evidence of Polyclonality
TL;DR: It is demonstrated by lineage tracing that metastases often involve seeding by more than one clone and that subsequent cellular outgrowth depends on the metastatic site, providing insight into clonal diversity and evolution in metastatic disease.
Journal ArticleDOI
Molecular profiling of single circulating tumor cells with diagnostic intention
Bernhard Polzer,Gianni Medoro,Sophie Pasch,Francesca Fontana,Laura Zorzino,Aurelia Pestka,Ulrich Andergassen,Franziska Meier-Stiegen,Zbigniew T. Czyż,Zbigniew T. Czyż,Barbara Alberter,Steffi Treitschke,Thomas Schamberger,M. Sergio,Giulia Bregola,Anna Doffini,Stefano Gianni,Alex Calanca,Giulio Signorini,Chiara Bolognesi,Arndt Hartmann,Peter A. Fasching,Maria T. Sandri,Brigitte Rack,Tanja Fehm,Giuseppe Giorgini,Nicolò Manaresi,Christoph Klein,Christoph Klein +28 more
TL;DR: Microheterogeneity analysis among individual CTCs uncovered pre‐existing cells resistant to ERBB2‐targeted therapies suggesting ongoing microevolution at late‐stage disease whose exploration may provide essential information for personalized treatment decisions and shed light into mechanisms of acquired drug resistance.
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Pan-cancer analysis of intratumor heterogeneity as a prognostic determinant of survival
Luc G. T. Morris,Nadeem Riaz,Alexis Desrichard,Yasin Senbabaoglu,A. Ari Hakimi,Vladimir Makarov,Jorge S. Reis-Filho,Timothy A. Chan +7 more
TL;DR: A pan-cancer analysis of over 3300 tumors shows that ITH is a prognostic marker in multiple cancers, indicating that tumor heterogeneity represents a significant obstacle to cancer control.
Journal ArticleDOI
Cancer heterogeneity—a multifaceted view
TL;DR: It is of utmost importance to understand the biological causes that distinguish tumours as well as distinct tumour cell populations within malignancies, as these will ultimately point the way to more rational anti‐cancer treatments.
References
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Journal ArticleDOI
Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics
Andrea Sottoriva,Andrea Sottoriva,Andrea Sottoriva,Inmaculada Spiteri,Sara Grazia Maria Piccirillo,Anestis Touloumis,V. Peter Collins,John C. Marioni,Christina Curtis,Colin Watts,Simon Tavaré,Simon Tavaré,Simon Tavaré +12 more
TL;DR: The genome-wide architecture of intratumor variability in GB is revealed across multiple spatial scales and patient-specific patterns of cancer evolution, with consequences for treatment design.
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Metastatic colonization by circulating tumour cells
TL;DR: An improved understanding of the mechanistic determinants of such colonization is needed to better prevent and treat metastatic cancer.
Journal ArticleDOI
Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia
Liran I. Shlush,Sasan Zandi,Amanda Mitchell,Weihsu Claire Chen,Joseph M. Brandwein,Vikas Gupta,James A. Kennedy,Aaron D. Schimmer,Andre C. Schuh,Karen W.L. Yee,Jessica McLeod,Monica Doedens,Jessie J. F. Medeiros,Rene Marke,Hyeoung Joon Kim,Kwon Lee,John Douglas Mcpherson,Thomas J. Hudson,Andrew M.K. Brown,Fouad Yousif,Quang M. Trinh,Lincoln Stein,Mark D. Minden,Jean C.Y. Wang,John E. Dick +24 more
TL;DR: Highly purified haematopoietic stem cells, progenitor and mature cell fractions from the blood of AML patients were found to contain recurrent DNMT3A mutations at high allele frequency, but without coincident NPM1 mutations (NPM1c) present in AML blasts.
Journal ArticleDOI
The evolutionary history of lethal metastatic prostate cancer.
Gunes Gundem,Peter Van Loo,Peter Van Loo,Peter Van Loo,Barbara Kremeyer,Ludmil B. Alexandrov,Jose M. C. Tubio,Elli Papaemmanuil,Daniel Brewer,Heini Kallio,Gunilla Högnäs,Matti Annala,Kati Kivinummi,Victoria Goody,Calli Latimer,Sarah O’Meara,Kevin J. Dawson,William B. Isaacs,Michael R. Emmert-Buck,Matti Nykter,Christopher S. Foster,Zsofia Kote-Jarai,Douglas F. Easton,Hayley C. Whitaker,David E. Neal,Colin Cooper,Colin Cooper,Rosalind A. Eeles,Rosalind A. Eeles,Tapio Visakorpi,Peter J. Campbell,Ultan McDermott,David C. Wedge,G. Steven Bova +33 more
TL;DR: In this article, the existence of polyclonal seeding in human malignancy and the clonal relationship among different metastases in the context of androgen-deprived metastatic prostate cancer was established.
Journal ArticleDOI
Clonal evolution in breast cancer revealed by single nucleus genome sequencing
Yong Wang,Jill Waters,Marco L. Leung,Anna K. Unruh,Whijae Roh,Xiuqing Shi,Ken Chen,Paul Scheet,Selina Vattathil,Han Liang,Asha S. Multani,Hong Zhang,Rui Zhao,Franziska Michor,Funda Meric-Bernstam,Nicholas Navin +15 more
TL;DR: The data show that aneuploid rearrangements occurred early in tumour evolution and remained highly stable as the tumour masses clonally expanded, which has important implications for the diagnosis, therapeutic treatment and evolution of chemoresistance in breast cancer.