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Clonal evolution in cancer
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The article was published on 2010-01-01 and is currently open access. It has received 817 citations till now. The article focuses on the topics: Somatic evolution in cancer & Cancer.read more
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Journal ArticleDOI
Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics
Andrea Sottoriva,Andrea Sottoriva,Andrea Sottoriva,Inmaculada Spiteri,Sara Grazia Maria Piccirillo,Anestis Touloumis,V. Peter Collins,John C. Marioni,Christina Curtis,Colin Watts,Simon Tavaré,Simon Tavaré,Simon Tavaré +12 more
TL;DR: The genome-wide architecture of intratumor variability in GB is revealed across multiple spatial scales and patient-specific patterns of cancer evolution, with consequences for treatment design.
Journal ArticleDOI
Metastatic colonization by circulating tumour cells
TL;DR: An improved understanding of the mechanistic determinants of such colonization is needed to better prevent and treat metastatic cancer.
Journal ArticleDOI
Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia
Liran I. Shlush,Sasan Zandi,Amanda Mitchell,Weihsu Claire Chen,Joseph M. Brandwein,Vikas Gupta,James A. Kennedy,Aaron D. Schimmer,Andre C. Schuh,Karen W.L. Yee,Jessica McLeod,Monica Doedens,Jessie J. F. Medeiros,Rene Marke,Hyeoung Joon Kim,Kwon Lee,John Douglas Mcpherson,Thomas J. Hudson,Andrew M.K. Brown,Fouad Yousif,Quang M. Trinh,Lincoln Stein,Mark D. Minden,Jean C.Y. Wang,John E. Dick +24 more
TL;DR: Highly purified haematopoietic stem cells, progenitor and mature cell fractions from the blood of AML patients were found to contain recurrent DNMT3A mutations at high allele frequency, but without coincident NPM1 mutations (NPM1c) present in AML blasts.
Journal Article
The evolutionary history of lethal metastatic prostate cancer
Gunes Gundem,P Van Loo,Barbara Kremeyer,Ludmil B. Alexandrov,Tubio Jmc.,Elli Papaemmanuil,Daniel Brewer,Heini Kallio,Gunilla Högnäs,Matti Annala,Kati Kivinummi,Victoria Goody,Calli Latimer,Sarah O’Meara,Kevin J. Dawson,William B. Isaacs,Michael R. Emmert-Buck,Matti Nykter,Claire Foster,Z Kote-Jarai,Doug Easton,Hayley C. Whitaker,David E. Neal,Colin Cooper,Rosalind A. Eeles,Tapio Visakorpi,Peter J. Campbell,Ultan McDermott,David C. Wedge,G S Bova +29 more
TL;DR: Using whole-genome sequencing, multiple metastases arising from prostate tumours in ten patients are characterized and the complex patterns of metastatic spread are elucidate in detail and the development of resistance to androgen-deprivation therapy in prostate cancer is understood.
Journal ArticleDOI
Clonal evolution in breast cancer revealed by single nucleus genome sequencing
Yong Wang,Jill Waters,Marco L. Leung,Anna K. Unruh,Whijae Roh,Xiuqing Shi,Ken Chen,Paul Scheet,Selina Vattathil,Han Liang,Asha S. Multani,Hong Zhang,Rui Zhao,Franziska Michor,Funda Meric-Bernstam,Nicholas Navin +15 more
TL;DR: The data show that aneuploid rearrangements occurred early in tumour evolution and remained highly stable as the tumour masses clonally expanded, which has important implications for the diagnosis, therapeutic treatment and evolution of chemoresistance in breast cancer.
References
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Copy number profiling of adult relapsed B-cell precursor acute lymphoblastic leukemia reveals potential leukemia progression mechanisms.
Jordi Ribera,Lurdes Zamora,Mireia Morgades,Mar Mallo,Neus Solanes,Montserrat Batlle,Susana Vives,Isabel Granada,Jordi Juncà,Roberto Malinverni,Eulàlia Genescà,Ramon Guardia,Santiago Mercadal,Lourdes Escoda,Joaquin Martinez-Lopez,Mar Tormo,Jordi Esteve,Marta Pratcorona,Carmen Martinez-Losada,Francesc Solé,Evarist Feliu,Josep-Maria Ribera +21 more
TL;DR: Genomics of relapsed adult B‐cell precursor ALL is highly heterogeneous, although some recurrent lesions involved in essential pathways deregulation were frequently observed, and selective and simultaneous targeting of these deregulated pathways may improve the results of current salvage therapies.
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Genomics of Cancer and a New Era for Cancer Prevention.
Paul Brennan,Christopher P. Wild +1 more
TL;DR: The potential for these techniques to identify cancers at an earlier and more treatable stage using screening or other early detection approaches based on prediagnostic biospecimens is large, and their successful outcome will depend on international collaboration and planning similar to that of recent sequencing initiatives.
Journal ArticleDOI
Proposed Terminology and Classification of Pre-Malignant Neoplastic Conditions: A Consensus Proposal.
Peter Valent,Cem Akin,Michel Arock,Christoph Bock,Tracy I. George,Stephen J. Galli,Jason Gotlib,Torsten Haferlach,Gregor Hoermann,Olivier Hermine,Ulrich Jäger,Lukas Kenner,Hans Kreipe,Ravindra Majeti,Dean D. Metcalfe,Alberto Orfao,Andreas Reiter,Wolfgang R. Sperr,Philipp B. Staber,Karl Sotlar,Charles A. Schiffer,Giulio Superti-Furga,Hans-Peter Horny +22 more
TL;DR: A basic proposal for a nomenclature and classification of pre-malignant conditions should assist in the communication among patients, physicians and scientists, which is critical as genome-sequencing will soon be offered widely for early cancer-detection.
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Statistical Molecule Counting in Super-Resolution Fluorescence Microscopy: Towards Quantitative Nanoscopy
TL;DR: In this article, a hidden Markov model is proposed to estimate the number of fluorescent markers in a statistically meaningful manner from the raw data generated by single-marker-switching (SMS) microscopy.
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Adaptive response of resistant cancer cells to chemotherapy
TL;DR: The mechanistic studies investigating the three major components of the adaptive response, autophagy, endoplasmic reticulum (ER) stress signaling, and senescence, in response to cancer chemotherapy are summarized.