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Clonal evolution in cancer
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The article was published on 2010-01-01 and is currently open access. It has received 817 citations till now. The article focuses on the topics: Somatic evolution in cancer & Cancer.read more
Citations
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Whole-genome and multisector exome sequencing of primary and post-treatment glioblastoma reveals patterns of tumor evolution
Hoon Kim,Siyuan Zheng,Seyed S. Amini,Selene Virk,Tom Mikkelsen,Daniel J. Brat,Jonna Grimsby,Carrie Sougnez,Florian L. Muller,Jian Hu,Andrew E. Sloan,Mark L. Cohen,Erwin G. Van Meir,Lisa Scarpace,Peter W. Laird,John N. Weinstein,Eric S. Lander,Stacey Gabriel,Gad Getz,Matthew Meyerson,Matthew Meyerson,Lynda Chin,Jill S. Barnholtz-Sloan,Roel G.W. Verhaak +23 more
TL;DR: This study used whole-genome sequencing and whole-exome sequencing of multiple sectors from primary and paired recurrent GBM tumors to reconstruct the genomic profile of residual, therapy resistant tumor initiating cells and found that genetic alteration of the p53 pathway is a primary molecular event predictive of a high number of subclonal mutations in glioblastoma.
Journal ArticleDOI
Extremely high genetic diversity in a single tumor points to prevalence of non-Darwinian cell evolution
Shaoping Ling,Zheng Hu,Z.F. Yang,Fang Yang,Yawei Li,Pei Lin,Ke Chen,Lili Dong,Lihua Cao,Yong Tao,Lingtong Hao,Qingjian Chen,Qiang Gong,Dafei Wu,Wenjie Li,Wenming Zhao,Xiuyun Tian,Chunyi Hao,Eric A. Hungate,Daniel V.T. Catenacci,Richard R. Hudson,Wen-Hsiung Li,Xuemei Lu,Chung-I Wu,Chung-I Wu,Chung-I Wu +25 more
TL;DR: A single tumor is evaluated by sequencing or genotyping nearly 300 regions from the tumor and the number of coding region mutations was estimated to be greater than 100 million in this unexceptional tumor, suggesting non-Darwinian evolution should be heeded in cancer treatments even for microscopic tumors.
Journal ArticleDOI
Ordering of mutations in preinvasive disease stages of esophageal carcinogenesis
Jamie M J Weaver,Caryn S. Ross-Innes,Nicholas B. Shannon,Andy G. Lynch,Tim Forshew,Mariagnese Barbera,Muhammed Murtaza,Chin-Ann Johnny Ong,Pierre Lao-Sirieix,Mark J Dunning,Laura Smith,Mike L. Smith,Charlotte Anderson,Benilton S. Carvalho,Maria O'Donovan,Timothy J. Underwood,Andrew May,Nicola Grehan,Richard H. Hardwick,Jim Davies,Arusha Oloumi,Samuel Aparicio,Carlos Caldas,Matthew D. Eldridge,Paul A.W. Edwards,Nitzan Rosenfeld,Simon Tavaré,Rebecca C. Fitzgerald +27 more
TL;DR: In conclusion, mutations in EAC driver genes generally occur exceptionally early in disease development with profound implications for diagnostic and therapeutic strategies.
Journal ArticleDOI
Limited heterogeneity of known driver gene mutations among the metastases of individual patients with pancreatic cancer
Alvin Makohon-Moore,Ming Zhang,Johannes G. Reiter,Ivana Bozic,Benjamin L. Allen,Benjamin L. Allen,Deepanjan Kundu,Krishnendu Chatterjee,Fay Wong,Yuchen Jiao,Zachary A. Kohutek,Jungeui Hong,Marc A. Attiyeh,Breanna Javier,Laura D. Wood,Ralph H. Hruban,Martin A. Nowak,Nickolas Papadopoulos,Kenneth W. Kinzler,Bert Vogelstein,Bert Vogelstein,Christine A. Iacobuzio-Donahue +21 more
TL;DR: The genetic similarity among the founding cells of metastases was higher than that expected for any two cells randomly taken from a normal tissue and has critical and encouraging implications for the success of future targeted therapies in advanced-stage disease.
Journal ArticleDOI
Classifying the evolutionary and ecological features of neoplasms
Carlo C. Maley,Athena Aktipis,Trevor A. Graham,Andrea Sottoriva,Amy M. Boddy,Michalina Janiszewska,Ariosto S. Silva,Marco Gerlinger,Yinyin Yuan,Kenneth J. Pienta,Karen S. Anderson,Robert A. Gatenby,Charles Swanton,David Posada,Chung I. Wu,Joshua D. Schiffman,E. Shelley Hwang,Kornelia Polyak,Alexander R. A. Anderson,Joel S. Brown,Mel Greaves,Darryl Shibata +21 more
TL;DR: A framework for classifying tumours is proposed that holds promise for enabling clinicians to personalize optimal interventions based on the evolvability of the patient's tumour, and the Evo- and Eco-indices provide a common lexicon for communicating about how neoplasms change in response to interventions.
References
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Journal ArticleDOI
Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics
Andrea Sottoriva,Andrea Sottoriva,Andrea Sottoriva,Inmaculada Spiteri,Sara Grazia Maria Piccirillo,Anestis Touloumis,V. Peter Collins,John C. Marioni,Christina Curtis,Colin Watts,Simon Tavaré,Simon Tavaré,Simon Tavaré +12 more
TL;DR: The genome-wide architecture of intratumor variability in GB is revealed across multiple spatial scales and patient-specific patterns of cancer evolution, with consequences for treatment design.
Journal ArticleDOI
Metastatic colonization by circulating tumour cells
TL;DR: An improved understanding of the mechanistic determinants of such colonization is needed to better prevent and treat metastatic cancer.
Journal ArticleDOI
Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia
Liran I. Shlush,Sasan Zandi,Amanda Mitchell,Weihsu Claire Chen,Joseph M. Brandwein,Vikas Gupta,James A. Kennedy,Aaron D. Schimmer,Andre C. Schuh,Karen W.L. Yee,Jessica McLeod,Monica Doedens,Jessie J. F. Medeiros,Rene Marke,Hyeoung Joon Kim,Kwon Lee,John Douglas Mcpherson,Thomas J. Hudson,Andrew M.K. Brown,Fouad Yousif,Quang M. Trinh,Lincoln Stein,Mark D. Minden,Jean C.Y. Wang,John E. Dick +24 more
TL;DR: Highly purified haematopoietic stem cells, progenitor and mature cell fractions from the blood of AML patients were found to contain recurrent DNMT3A mutations at high allele frequency, but without coincident NPM1 mutations (NPM1c) present in AML blasts.
Journal ArticleDOI
The evolutionary history of lethal metastatic prostate cancer.
Gunes Gundem,Peter Van Loo,Peter Van Loo,Peter Van Loo,Barbara Kremeyer,Ludmil B. Alexandrov,Jose M. C. Tubio,Elli Papaemmanuil,Daniel Brewer,Heini Kallio,Gunilla Högnäs,Matti Annala,Kati Kivinummi,Victoria Goody,Calli Latimer,Sarah O’Meara,Kevin J. Dawson,William B. Isaacs,Michael R. Emmert-Buck,Matti Nykter,Christopher S. Foster,Zsofia Kote-Jarai,Douglas F. Easton,Hayley C. Whitaker,David E. Neal,Colin Cooper,Colin Cooper,Rosalind A. Eeles,Rosalind A. Eeles,Tapio Visakorpi,Peter J. Campbell,Ultan McDermott,David C. Wedge,G. Steven Bova +33 more
TL;DR: In this article, the existence of polyclonal seeding in human malignancy and the clonal relationship among different metastases in the context of androgen-deprived metastatic prostate cancer was established.
Journal ArticleDOI
Clonal evolution in breast cancer revealed by single nucleus genome sequencing
Yong Wang,Jill Waters,Marco L. Leung,Anna K. Unruh,Whijae Roh,Xiuqing Shi,Ken Chen,Paul Scheet,Selina Vattathil,Han Liang,Asha S. Multani,Hong Zhang,Rui Zhao,Franziska Michor,Funda Meric-Bernstam,Nicholas Navin +15 more
TL;DR: The data show that aneuploid rearrangements occurred early in tumour evolution and remained highly stable as the tumour masses clonally expanded, which has important implications for the diagnosis, therapeutic treatment and evolution of chemoresistance in breast cancer.