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Clonal evolution in cancer
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The article was published on 2010-01-01 and is currently open access. It has received 817 citations till now. The article focuses on the topics: Somatic evolution in cancer & Cancer.read more
Citations
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Intra-tumour heterogeneity – going beyond genetics
TL;DR: Understanding how cancer genetics synergize with the emerging non‐genetic factors will be key for development of therapies able to tackle tumour escape and thereby improve cancer patient survival is believed to be key.
Journal ArticleDOI
Applying ecological and evolutionary theory to cancer: a long and winding road
Frédéric Thomas,Daniel Fisher,Philippe Fort,Jean-Pierre Marie,Simon P. Daoust,Benjamin Roche,Christoph Grunau,Céline Cosseau,Guillaume Mitta,Stephen Baghdiguian,François Rousset,Patrice Lassus,Eric Assenat,Damien Grégoire,Dorothée Missé,Alexander Lorz,Frédérique Billy,W. Vainchenker,François Delhommeau,Serge Koscielny,Raphael Itzykson,Ruoping Tang,Fanny Fava,Annabelle Ballesta,Thomas Lepoutre,Liliana Krasinska,Liliana Krasinska,Vjekoslav Dulic,Vjekoslav Dulic,Peggy Raynaud,Peggy Raynaud,Philippe Blache,Corinne Quittau-Prévostel,Corinne Quittau-Prévostel,Emmanuel Vignal,Emmanuel Vignal,Helene Trauchessec,Benoît Perthame,Jean Clairambault,Vitali Volpert,Eric Solary,Urszula Hibner,Michael E. Hochberg +42 more
TL;DR: The objective of this introduction is to describe the basic ideas and concepts linking evolutionary biology to cancer, and to present four major fronts where the evolutionary perspective is most developed, namely laboratory and clinical models, mathematical models, databases, and techniques and assays.
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A general framework for analyzing tumor subclonality using SNP array and DNA sequencing data.
TL;DR: The Clonal Heterogeneity Analysis Tool is presented, which estimates cellular fractions for both sCNAs and mutations, and uses their distributions to inform macroscopic clonal architecture.
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Cancer stem cells as ‘units of selection’
TL;DR: The so‐called ‘cancer stem cells’ have the essential properties required to function as the key units of selection, particularly with respect to their proliferative potential and longevity.
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Tracking the evolution of cancer cell populations through the mathematical lens of phenotype-structured equations
TL;DR: The theoretical work offers a formal basis for the development of anti-cancer therapeutic protocols that go beyond the ‘maximum-tolerated-dose paradigm’, as they may be more effective than traditional protocols at keeping the size of cancer cell populations under control while avoiding the expansion of drug tolerant clones.
References
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Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics
Andrea Sottoriva,Andrea Sottoriva,Andrea Sottoriva,Inmaculada Spiteri,Sara Grazia Maria Piccirillo,Anestis Touloumis,V. Peter Collins,John C. Marioni,Christina Curtis,Colin Watts,Simon Tavaré,Simon Tavaré,Simon Tavaré +12 more
TL;DR: The genome-wide architecture of intratumor variability in GB is revealed across multiple spatial scales and patient-specific patterns of cancer evolution, with consequences for treatment design.
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Metastatic colonization by circulating tumour cells
TL;DR: An improved understanding of the mechanistic determinants of such colonization is needed to better prevent and treat metastatic cancer.
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Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia
Liran I. Shlush,Sasan Zandi,Amanda Mitchell,Weihsu Claire Chen,Joseph M. Brandwein,Vikas Gupta,James A. Kennedy,Aaron D. Schimmer,Andre C. Schuh,Karen W.L. Yee,Jessica McLeod,Monica Doedens,Jessie J. F. Medeiros,Rene Marke,Hyeoung Joon Kim,Kwon Lee,John Douglas Mcpherson,Thomas J. Hudson,Andrew M.K. Brown,Fouad Yousif,Quang M. Trinh,Lincoln Stein,Mark D. Minden,Jean C.Y. Wang,John E. Dick +24 more
TL;DR: Highly purified haematopoietic stem cells, progenitor and mature cell fractions from the blood of AML patients were found to contain recurrent DNMT3A mutations at high allele frequency, but without coincident NPM1 mutations (NPM1c) present in AML blasts.
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The evolutionary history of lethal metastatic prostate cancer.
Gunes Gundem,Peter Van Loo,Peter Van Loo,Peter Van Loo,Barbara Kremeyer,Ludmil B. Alexandrov,Jose M. C. Tubio,Elli Papaemmanuil,Daniel Brewer,Heini Kallio,Gunilla Högnäs,Matti Annala,Kati Kivinummi,Victoria Goody,Calli Latimer,Sarah O’Meara,Kevin J. Dawson,William B. Isaacs,Michael R. Emmert-Buck,Matti Nykter,Christopher S. Foster,Zsofia Kote-Jarai,Douglas F. Easton,Hayley C. Whitaker,David E. Neal,Colin Cooper,Colin Cooper,Rosalind A. Eeles,Rosalind A. Eeles,Tapio Visakorpi,Peter J. Campbell,Ultan McDermott,David C. Wedge,G. Steven Bova +33 more
TL;DR: In this article, the existence of polyclonal seeding in human malignancy and the clonal relationship among different metastases in the context of androgen-deprived metastatic prostate cancer was established.
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Clonal evolution in breast cancer revealed by single nucleus genome sequencing
Yong Wang,Jill Waters,Marco L. Leung,Anna K. Unruh,Whijae Roh,Xiuqing Shi,Ken Chen,Paul Scheet,Selina Vattathil,Han Liang,Asha S. Multani,Hong Zhang,Rui Zhao,Franziska Michor,Funda Meric-Bernstam,Nicholas Navin +15 more
TL;DR: The data show that aneuploid rearrangements occurred early in tumour evolution and remained highly stable as the tumour masses clonally expanded, which has important implications for the diagnosis, therapeutic treatment and evolution of chemoresistance in breast cancer.