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Clonal evolution in cancer
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The article was published on 2010-01-01 and is currently open access. It has received 817 citations till now. The article focuses on the topics: Somatic evolution in cancer & Cancer.read more
Citations
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Journal ArticleDOI
Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics
Andrea Sottoriva,Andrea Sottoriva,Andrea Sottoriva,Inmaculada Spiteri,Sara Grazia Maria Piccirillo,Anestis Touloumis,V. Peter Collins,John C. Marioni,Christina Curtis,Colin Watts,Simon Tavaré,Simon Tavaré,Simon Tavaré +12 more
TL;DR: The genome-wide architecture of intratumor variability in GB is revealed across multiple spatial scales and patient-specific patterns of cancer evolution, with consequences for treatment design.
Journal ArticleDOI
Metastatic colonization by circulating tumour cells
TL;DR: An improved understanding of the mechanistic determinants of such colonization is needed to better prevent and treat metastatic cancer.
Journal ArticleDOI
Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia
Liran I. Shlush,Sasan Zandi,Amanda Mitchell,Weihsu Claire Chen,Joseph M. Brandwein,Vikas Gupta,James A. Kennedy,Aaron D. Schimmer,Andre C. Schuh,Karen W.L. Yee,Jessica McLeod,Monica Doedens,Jessie J. F. Medeiros,Rene Marke,Hyeoung Joon Kim,Kwon Lee,John Douglas Mcpherson,Thomas J. Hudson,Andrew M.K. Brown,Fouad Yousif,Quang M. Trinh,Lincoln Stein,Mark D. Minden,Jean C.Y. Wang,John E. Dick +24 more
TL;DR: Highly purified haematopoietic stem cells, progenitor and mature cell fractions from the blood of AML patients were found to contain recurrent DNMT3A mutations at high allele frequency, but without coincident NPM1 mutations (NPM1c) present in AML blasts.
Journal Article
The evolutionary history of lethal metastatic prostate cancer
Gunes Gundem,P Van Loo,Barbara Kremeyer,Ludmil B. Alexandrov,Tubio Jmc.,Elli Papaemmanuil,Daniel Brewer,Heini Kallio,Gunilla Högnäs,Matti Annala,Kati Kivinummi,Victoria Goody,Calli Latimer,Sarah O’Meara,Kevin J. Dawson,William B. Isaacs,Michael R. Emmert-Buck,Matti Nykter,Claire Foster,Z Kote-Jarai,Doug Easton,Hayley C. Whitaker,David E. Neal,Colin Cooper,Rosalind A. Eeles,Tapio Visakorpi,Peter J. Campbell,Ultan McDermott,David C. Wedge,G S Bova +29 more
TL;DR: Using whole-genome sequencing, multiple metastases arising from prostate tumours in ten patients are characterized and the complex patterns of metastatic spread are elucidate in detail and the development of resistance to androgen-deprivation therapy in prostate cancer is understood.
Journal ArticleDOI
Clonal evolution in breast cancer revealed by single nucleus genome sequencing
Yong Wang,Jill Waters,Marco L. Leung,Anna K. Unruh,Whijae Roh,Xiuqing Shi,Ken Chen,Paul Scheet,Selina Vattathil,Han Liang,Asha S. Multani,Hong Zhang,Rui Zhao,Franziska Michor,Funda Meric-Bernstam,Nicholas Navin +15 more
TL;DR: The data show that aneuploid rearrangements occurred early in tumour evolution and remained highly stable as the tumour masses clonally expanded, which has important implications for the diagnosis, therapeutic treatment and evolution of chemoresistance in breast cancer.
References
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Dissertation
Biomarkers of mismatch repair deficiency in colorectal cancer and cancer predisposition syndromes
TL;DR: In this paper, acknowledgements and acknowledgements are given for the work presented in this paper: https://www.gazetteer.com.au/blogs/blogs.
Posted ContentDOI
Multi-modal meta-analysis of 1494 hepatocellular carcinoma samples reveals vast impacts of consensus driver genes on phenotypes
TL;DR: This study consolidates a group of consensus driver genes in HCC which collectively show vast impacts on the phenotypes and may warrant as valuable therapeutic targets of HCC.
Journal ArticleDOI
Evidence for a Functional Link between Chromosomal Breakpoints and Aberrant DNA Methylation in Cancer
Sven Bilke,Yevgeniy Gindin +1 more
TL;DR: The tumor “clonal evolution” aspect is investigated by analyzing the gene content proximal to the BEDMRs, which find several cancer biology relevant genes, such as AKT1, ARNT, and PMS2 and their literature analysis finds that 57% of the BedMRs overlap with at least one gene that has more than three literature references related to cancer.
Journal ArticleDOI
Functional genomic screening to enhance oncolytic virotherapy.
TL;DR: The thoughts on the future of RNAi screening as a tool to enhance OVT are given and recent technical improvements that are poised to make genome-scale RNAi experiments more sensitive, less noisy, more applicable in vivo, and more easily validated in clinically relevant animal models are described.
Dissertation
Metabolic rewiring in response to genetic and environmental preturbations in cancer
TL;DR: A metabolic vulnerability that could be therapeutically targeted to treat SDH-mutated tumours is revealed, and a novel redox-sensitive metabolic pathway is exhibited by both pseudohypoxic SDH and IDH1 mutated tumours, used to retain metabolic plasticity.