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Clonal evolution in cancer
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The article was published on 2010-01-01 and is currently open access. It has received 817 citations till now. The article focuses on the topics: Somatic evolution in cancer & Cancer.read more
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Journal ArticleDOI
Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics
Andrea Sottoriva,Andrea Sottoriva,Andrea Sottoriva,Inmaculada Spiteri,Sara Grazia Maria Piccirillo,Anestis Touloumis,V. Peter Collins,John C. Marioni,Christina Curtis,Colin Watts,Simon Tavaré,Simon Tavaré,Simon Tavaré +12 more
TL;DR: The genome-wide architecture of intratumor variability in GB is revealed across multiple spatial scales and patient-specific patterns of cancer evolution, with consequences for treatment design.
Journal ArticleDOI
Metastatic colonization by circulating tumour cells
TL;DR: An improved understanding of the mechanistic determinants of such colonization is needed to better prevent and treat metastatic cancer.
Journal ArticleDOI
Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia
Liran I. Shlush,Sasan Zandi,Amanda Mitchell,Weihsu Claire Chen,Joseph M. Brandwein,Vikas Gupta,James A. Kennedy,Aaron D. Schimmer,Andre C. Schuh,Karen W.L. Yee,Jessica McLeod,Monica Doedens,Jessie J. F. Medeiros,Rene Marke,Hyeoung Joon Kim,Kwon Lee,John Douglas Mcpherson,Thomas J. Hudson,Andrew M.K. Brown,Fouad Yousif,Quang M. Trinh,Lincoln Stein,Mark D. Minden,Jean C.Y. Wang,John E. Dick +24 more
TL;DR: Highly purified haematopoietic stem cells, progenitor and mature cell fractions from the blood of AML patients were found to contain recurrent DNMT3A mutations at high allele frequency, but without coincident NPM1 mutations (NPM1c) present in AML blasts.
Journal Article
The evolutionary history of lethal metastatic prostate cancer
Gunes Gundem,P Van Loo,Barbara Kremeyer,Ludmil B. Alexandrov,Tubio Jmc.,Elli Papaemmanuil,Daniel Brewer,Heini Kallio,Gunilla Högnäs,Matti Annala,Kati Kivinummi,Victoria Goody,Calli Latimer,Sarah O’Meara,Kevin J. Dawson,William B. Isaacs,Michael R. Emmert-Buck,Matti Nykter,Claire Foster,Z Kote-Jarai,Doug Easton,Hayley C. Whitaker,David E. Neal,Colin Cooper,Rosalind A. Eeles,Tapio Visakorpi,Peter J. Campbell,Ultan McDermott,David C. Wedge,G S Bova +29 more
TL;DR: Using whole-genome sequencing, multiple metastases arising from prostate tumours in ten patients are characterized and the complex patterns of metastatic spread are elucidate in detail and the development of resistance to androgen-deprivation therapy in prostate cancer is understood.
Journal ArticleDOI
Clonal evolution in breast cancer revealed by single nucleus genome sequencing
Yong Wang,Jill Waters,Marco L. Leung,Anna K. Unruh,Whijae Roh,Xiuqing Shi,Ken Chen,Paul Scheet,Selina Vattathil,Han Liang,Asha S. Multani,Hong Zhang,Rui Zhao,Franziska Michor,Funda Meric-Bernstam,Nicholas Navin +15 more
TL;DR: The data show that aneuploid rearrangements occurred early in tumour evolution and remained highly stable as the tumour masses clonally expanded, which has important implications for the diagnosis, therapeutic treatment and evolution of chemoresistance in breast cancer.
References
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Stochasticity in the Genotype-Phenotype Map: Implications for the Robustness and Persistence of Bet-Hedging.
TL;DR: This work studies how bet-hedging emerges in genotype–phenotype (GP) mapping through a simple interaction model: a molecular switch, and investigates the impact of structurally distinct mappings on the evolution of phenotypic heterogeneity.
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Hypermutable DNA chronicles the evolution of human colon cancer
Kamila Naxerova,Elena F. Brachtel,Jesse J. Salk,Aaron M. Seese,Karen A. Power,Bardia Abbasi,Matija Snuderl,Sarah Chiang,Simon Kasif,Simon Kasif,Rakesh K. Jain +10 more
TL;DR: It is reported that a simple PCR-based assay interrogating somatic variation in hypermutable polyguanine (poly-G) repeats can provide a rapid and reliable assessment of mitotic history and clonal architecture in human cancer.
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The structural basis for cancer treatment decisions.
TL;DR: Improved tumor mutational analysis platforms and knowledge of the redundant pathways which can take over in cancer, may not only supplement known actionable findings, but forecast possible cancer progression and resistance, and consequently more informed treatment options.
Journal ArticleDOI
Prognostic Model to Predict Post-Autologous Stem-Cell Transplantation Outcomes in Classical Hodgkin Lymphoma
Fong Chun Chan,Anja Mottok,Alina S. Gerrie,Maryse M. Power,Marcel Nijland,Arjan Diepstra,Anke van den Berg,Peter Kamper,Francesco d'Amore,Alexander Lindholm d'Amore,Stephen Hamilton-Dutoit,Kerry J. Savage,Sohrab P. Shah,Joseph M. Connors,Randy D. Gascoyne,David W. Scott,Christian Steidl +16 more
TL;DR: Comparative analysis of the prognostic power of gene expression measurements in primary versus relapse specimens demonstrated that the biology captured at the time of relapse contained superior properties for post-ASCT outcome prediction.
Journal ArticleDOI
Biological and Clinical Implications of Clonal Heterogeneity and Clonal Evolution in Multiple Myeloma.
Giada Bianchi,Irene M. Ghobrial +1 more
TL;DR: A historical excursus is presented on the concepts of clonal heterogeneity and clonal evolution in multiple myeloma with a special emphasis on their role in the progression from MGUS to MM; the contribution of the microenvironment; and the clinical implications in terms of resistance to treatment and disease relapse/recurrence.