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Clonal evolution in cancer
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The article was published on 2010-01-01 and is currently open access. It has received 817 citations till now. The article focuses on the topics: Somatic evolution in cancer & Cancer.read more
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Validation and implementation of a method for microarray gene expression profiling of minor B-cell subpopulations in man
Kim Steve Bergkvist,Mette Nyegaard,Mette Nyegaard,Martin Bøgsted,Alexander Schmitz,Julie Støve Bødker,Simon Mylius Rasmussen,Martin Perez-Andres,Steffen Falgreen,Anders Ellern Bilgrau,Malene Krag Kjeldsen,Michael Gaihede,Martin Agge Nørgaard,John Bæch,Marie-Louise M. Grønholdt,Frank Jensen,Preben Johansen,Karen Dybkær,Hans Erik Johnsen +18 more
TL;DR: The workflow described in this report will enable the generation of microarray data from minor sorted B-cell subsets by using fluorescence-activated cell sorting and RNA amplification to generation of a gene-specific B- cell atlas.
Journal ArticleDOI
Highly sensitive detection of mutations in CHO cell recombinant DNA using multi-parallel single molecule real-time DNA sequencing.
TL;DR: The abundance of mutations that fall outside of the reported range of detection of next generation sequencing (NGS) and secondgeneration sequencing (SGS) platforms are demonstrated, providing a methodology capable of being utilized in cell line development platforms to identify the fidelity of recombinant genes throughout the production process.
C URRENT OPINION Common progenitor cells in mature B-cell malignancies: implications for therapy
Michael R. Green,Ash A. Alizadeh +1 more
TL;DR: A recent review as mentioned in this paper summarizes the recent progress in defining the patterns of genetic evolution giving rise to relapse in follicular lymphoma and multiple myeloma, and discusses their implications with respect to personalized medicine.
Journal ArticleDOI
Genotyping of Circulating Tumor DNA Reveals the Clinically-actionable Mutation Landscape of Advanced Colorectal Cancer
Weiguo Cao,Yaping Xu,Lianpeng Chang,Yuhua Gong,Liren Li,Xianwei Mo,Xin Zhang,Guole Lin,Jiaolin Zhou,Dan Liu,Yuting Yi,Pingping Dai,Chenchen Zhu,Liu Tao,Yuxing Chu,Yanfang Guan,Yongsheng Chen,Jiayin Wang,Xuefeng Xia,Ling Yang,Xin Yi,Yong Cheng +21 more
TL;DR: Comprehensive ctDNA genotyping is a promising noninvasive alternative to biopsy-derived analysis for determining targeted therapy in advanced colorectal cancer and shows favorable concordance with tumor tissues in the authors' matched analysis.
Journal ArticleDOI
Poorly differentiated clusters with larger extents have a greater impact on survival: a semi-quantitative pathological evaluation for 239 patients with non-mucinous pT2-3 colorectal carcinoma.
Osamu Kinoshita,Mitsuo Kishimoto,Yasutoshi Murayama,Satoru Yasukawa,Eiichi Konishi,Eigo Otsuji,Akio Yanagisawa +6 more
TL;DR: The results suggest that G3 PDCs with a larger extent are closely associated with unfavorable patient outcome, and Quantitative evaluation that takes into account the extent of P DCs would provide more concise prognostic information.
References
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Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics
Andrea Sottoriva,Andrea Sottoriva,Andrea Sottoriva,Inmaculada Spiteri,Sara Grazia Maria Piccirillo,Anestis Touloumis,V. Peter Collins,John C. Marioni,Christina Curtis,Colin Watts,Simon Tavaré,Simon Tavaré,Simon Tavaré +12 more
TL;DR: The genome-wide architecture of intratumor variability in GB is revealed across multiple spatial scales and patient-specific patterns of cancer evolution, with consequences for treatment design.
Journal ArticleDOI
Metastatic colonization by circulating tumour cells
TL;DR: An improved understanding of the mechanistic determinants of such colonization is needed to better prevent and treat metastatic cancer.
Journal ArticleDOI
Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia
Liran I. Shlush,Sasan Zandi,Amanda Mitchell,Weihsu Claire Chen,Joseph M. Brandwein,Vikas Gupta,James A. Kennedy,Aaron D. Schimmer,Andre C. Schuh,Karen W.L. Yee,Jessica McLeod,Monica Doedens,Jessie J. F. Medeiros,Rene Marke,Hyeoung Joon Kim,Kwon Lee,John Douglas Mcpherson,Thomas J. Hudson,Andrew M.K. Brown,Fouad Yousif,Quang M. Trinh,Lincoln Stein,Mark D. Minden,Jean C.Y. Wang,John E. Dick +24 more
TL;DR: Highly purified haematopoietic stem cells, progenitor and mature cell fractions from the blood of AML patients were found to contain recurrent DNMT3A mutations at high allele frequency, but without coincident NPM1 mutations (NPM1c) present in AML blasts.
Journal ArticleDOI
The evolutionary history of lethal metastatic prostate cancer.
Gunes Gundem,Peter Van Loo,Peter Van Loo,Peter Van Loo,Barbara Kremeyer,Ludmil B. Alexandrov,Jose M. C. Tubio,Elli Papaemmanuil,Daniel Brewer,Heini Kallio,Gunilla Högnäs,Matti Annala,Kati Kivinummi,Victoria Goody,Calli Latimer,Sarah O’Meara,Kevin J. Dawson,William B. Isaacs,Michael R. Emmert-Buck,Matti Nykter,Christopher S. Foster,Zsofia Kote-Jarai,Douglas F. Easton,Hayley C. Whitaker,David E. Neal,Colin Cooper,Colin Cooper,Rosalind A. Eeles,Rosalind A. Eeles,Tapio Visakorpi,Peter J. Campbell,Ultan McDermott,David C. Wedge,G. Steven Bova +33 more
TL;DR: In this article, the existence of polyclonal seeding in human malignancy and the clonal relationship among different metastases in the context of androgen-deprived metastatic prostate cancer was established.
Journal ArticleDOI
Clonal evolution in breast cancer revealed by single nucleus genome sequencing
Yong Wang,Jill Waters,Marco L. Leung,Anna K. Unruh,Whijae Roh,Xiuqing Shi,Ken Chen,Paul Scheet,Selina Vattathil,Han Liang,Asha S. Multani,Hong Zhang,Rui Zhao,Franziska Michor,Funda Meric-Bernstam,Nicholas Navin +15 more
TL;DR: The data show that aneuploid rearrangements occurred early in tumour evolution and remained highly stable as the tumour masses clonally expanded, which has important implications for the diagnosis, therapeutic treatment and evolution of chemoresistance in breast cancer.