Open Access
Clonal evolution in cancer
Reads0
Chats0
About:
The article was published on 2010-01-01 and is currently open access. It has received 817 citations till now. The article focuses on the topics: Somatic evolution in cancer & Cancer.read more
Citations
More filters
Journal ArticleDOI
Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics
Andrea Sottoriva,Andrea Sottoriva,Andrea Sottoriva,Inmaculada Spiteri,Sara Grazia Maria Piccirillo,Anestis Touloumis,V. Peter Collins,John C. Marioni,Christina Curtis,Colin Watts,Simon Tavaré,Simon Tavaré,Simon Tavaré +12 more
TL;DR: The genome-wide architecture of intratumor variability in GB is revealed across multiple spatial scales and patient-specific patterns of cancer evolution, with consequences for treatment design.
Journal ArticleDOI
Metastatic colonization by circulating tumour cells
TL;DR: An improved understanding of the mechanistic determinants of such colonization is needed to better prevent and treat metastatic cancer.
Journal ArticleDOI
Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia
Liran I. Shlush,Sasan Zandi,Amanda Mitchell,Weihsu Claire Chen,Joseph M. Brandwein,Vikas Gupta,James A. Kennedy,Aaron D. Schimmer,Andre C. Schuh,Karen W.L. Yee,Jessica McLeod,Monica Doedens,Jessie J. F. Medeiros,Rene Marke,Hyeoung Joon Kim,Kwon Lee,John Douglas Mcpherson,Thomas J. Hudson,Andrew M.K. Brown,Fouad Yousif,Quang M. Trinh,Lincoln Stein,Mark D. Minden,Jean C.Y. Wang,John E. Dick +24 more
TL;DR: Highly purified haematopoietic stem cells, progenitor and mature cell fractions from the blood of AML patients were found to contain recurrent DNMT3A mutations at high allele frequency, but without coincident NPM1 mutations (NPM1c) present in AML blasts.
Journal Article
The evolutionary history of lethal metastatic prostate cancer
Gunes Gundem,P Van Loo,Barbara Kremeyer,Ludmil B. Alexandrov,Tubio Jmc.,Elli Papaemmanuil,Daniel Brewer,Heini Kallio,Gunilla Högnäs,Matti Annala,Kati Kivinummi,Victoria Goody,Calli Latimer,Sarah O’Meara,Kevin J. Dawson,William B. Isaacs,Michael R. Emmert-Buck,Matti Nykter,Claire Foster,Z Kote-Jarai,Doug Easton,Hayley C. Whitaker,David E. Neal,Colin Cooper,Rosalind A. Eeles,Tapio Visakorpi,Peter J. Campbell,Ultan McDermott,David C. Wedge,G S Bova +29 more
TL;DR: Using whole-genome sequencing, multiple metastases arising from prostate tumours in ten patients are characterized and the complex patterns of metastatic spread are elucidate in detail and the development of resistance to androgen-deprivation therapy in prostate cancer is understood.
Journal ArticleDOI
Clonal evolution in breast cancer revealed by single nucleus genome sequencing
Yong Wang,Jill Waters,Marco L. Leung,Anna K. Unruh,Whijae Roh,Xiuqing Shi,Ken Chen,Paul Scheet,Selina Vattathil,Han Liang,Asha S. Multani,Hong Zhang,Rui Zhao,Franziska Michor,Funda Meric-Bernstam,Nicholas Navin +15 more
TL;DR: The data show that aneuploid rearrangements occurred early in tumour evolution and remained highly stable as the tumour masses clonally expanded, which has important implications for the diagnosis, therapeutic treatment and evolution of chemoresistance in breast cancer.
References
More filters
Journal ArticleDOI
TrAp: a Tree Approach for Fingerprinting Subclonal Tumor Composition
TL;DR: An evolutionary framework for deconvolving data from a single genome-wide experiment to infer the composition, abundance and evolutionary paths of the underlying cell subpopulations of a tumor is proposed.
Journal ArticleDOI
Identification of Positively and Negatively Selected Driver Gene Mutations Associated With Colorectal Cancer With Microsatellite Instability.
Vincent Jonchère,Laetitia Marisa,Malorie Greene,Alain Virouleau,Alain Virouleau,Olivier Buhard,Romane Bertrand,Magali Svrcek,Pascale Cervera,Anastasia R. Goloudina,Erell Guillerm,Florence Coulet,Samuel Landman,Toky Ratovomanana,Sylvie Job,Mira Ayadi,Nabila Elarouci,Lucile Armenoult,Fatiha Merabtene,Sylvie Dumont,Yann Parc,Jérémie H. Lefevre,Thierry André,Jean-François Fléjou,Agathe Guilloux,Ada Collura,Aurélien de Reyniès,Alex Duval +27 more
TL;DR: The present results identify the positive and negative driver somatic mutations acting in MSI-driven tumorigenesis, suggesting that genomic instability in MSI CRC plays a dual role in achieving tumor cell transformation.
Journal ArticleDOI
Evolutionary Origins of Cancer Driver Genes and Implications for Cancer Prognosis
TL;DR: Through analyzing the cancer endogenous molecular networks, it is revealed that the subnetwork originating from eukaryota could control the unlimited proliferation of cancer cells, and the sub network originating fromeumetazoa could recapitulate the other hallmarks of cancer.
Journal ArticleDOI
Computational approach for deriving cancer progression roadmaps from static sample data.
TL;DR: A computational strategy is presented that enables the construction of a cancer progression model using static tumor sample data and reveals a linear, branching model with two distinct trajectories for malignant progression.
Journal ArticleDOI
Serotype-Specific Killing of Large Cell Carcinoma Cells by Reovirus.
TL;DR: Results indicate that recombinant reoviruses recapitulate the cell killing properties of non-recombinant, tissue culture-passaged strains, which raises the possibility that type 1 reovirus may have the capacity to serve as more effective oncolytics than type 3 reoviral in some tumor types.