Comorbidity and its Impact on Patients with COVID-19.
Adekunle Sanyaolu,Chuku Okorie,Aleksandra Marinkovic,Risha Patidar,Kokab Younis,Priyank Desai,Zaheeda Hosein,Inderbir S. Padda,Jasmine Mangat,Mohsin Altaf +9 more
- Vol. 2, Iss: 8, pp 1-8
TLDR
Examination of the comorbid conditions, the progression of the disease, and mortality rates in patients of all ages, infected with the ongoing COVID-19 disease found that patients withComorbidities should take all necessary precautions to avoid getting infected with SARS CoV-2, as they usually have the worst prognosis.Abstract:
A novel human coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was identified in Wuhan, China, in December 2019. Since then, the virus has made its way across the globe to affect over 180 countries. SARS-CoV-2 has infected humans in all age groups, of all ethnicities, both males and females while spreading through communities at an alarming rate. Given the nature of this virus, there is much still to be learned; however, we know that the clinical manifestations range from a common cold to more severe diseases such as bronchitis, pneumonia, severe acute respiratory distress syndrome (ARDS), multi-organ failure, and even death. It is believed that COVID-19, in those with underlying health conditions or comorbidities, has an increasingly rapid and severe progression, often leading to death. This paper examined the comorbid conditions, the progression of the disease, and mortality rates in patients of all ages, infected with the ongoing COVID-19 disease. An electronic literature review search was performed, and applicable data was then collected from peer-reviewed articles published from January to April 20, 2020. From what is known at the moment, patients with COVID-19 disease who have comorbidities, such as hypertension or diabetes mellitus, are more likely to develop a more severe course and progression of the disease. Furthermore, older patients, especially those 65 years old and above who have comorbidities and are infected, have an increased admission rate into the intensive care unit (ICU) and mortality from the COVID-19 disease. Patients with comorbidities should take all necessary precautions to avoid getting infected with SARS CoV-2, as they usually have the worst prognosis.read more
Citations
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Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study
Fei Zhou,Ting Yu,Ronghui Du,Guohui Fan,Ying Liu,Zhibo Liu,Jie Xiang,Yeming Wang,Bin Song,Xiaoying Gu,Xiaoying Gu,Lulu Guan,Yuan Wei,Li Hui,Xudong Wu,Jiuyang Xu,Shengjin Tu,Yi Zhang,Hua Chen,Bin Cao +19 more
TL;DR: Prolonged viral shedding provides the rationale for a strategy of isolation of infected patients and optimal antiviral interventions in the future.
Journal ArticleDOI
COVID-19 and healthcare workers: A systematic review and meta-analysis.
Mandana Gholami,Iman Fawad,Sidra Shadan,Rashed Rowaiee,HedaietAllah Ghanem,Amar Hassan Khamis,Samuel B. Ho,Samuel B. Ho +7 more
TL;DR: In this article, the authors describe the clinical outcomes and risk factors for SARS-CoV-2 infection in frontline healthcare workers (HCW) during the COVID-19 pandemic.
Journal ArticleDOI
Diabetes is most important cause for mortality in COVID-19 hospitalized patients: Systematic review and meta-analysis.
Giovanni Corona,Alessandro Pizzocaro,Walter Vena,Giulia Rastrelli,Federico Semeraro,Andrea M. Isidori,Rosario Pivonello,Andrea Salonia,Alessandra Sforza,Mario Maggi +9 more
TL;DR: Reduced lymphocyte and platelet count, along with increased D-dimer levels, all significantly contributed to increased mortality and the optimization of glucose profile along with an adequate thrombotic complications preventive strategy must become routine practice in diseased SARS-CoV-2 infected patients.
Journal ArticleDOI
Hypertension delays viral clearance and exacerbates airway hyperinflammation in patients with COVID-19.
Saskia Trump,Soeren Lukassen,Markus S. Anker,Robert Lorenz Chua,Johannes Liebig,Loreen Thürmann,Victor M. Corman,Marco Binder,Jennifer Loske,Christina Klasa,Teresa G Krieger,Bianca P Hennig,Marey Messingschlager,Fabian Pott,Julia Kazmierski,Sven Twardziok,Jan Philipp Albrecht,Jürgen Eils,Sara Hadzibegovic,Alessia Lena,Bettina Heidecker,Thore Bürgel,Jakob Steinfeldt,Christine Goffinet,Florian Kurth,Florian Kurth,Martin Witzenrath,Maria Theresa Völker,Sarah Dorothea Müller,Uwe G. Liebert,Naveed Ishaque,Lars Kaderali,Leif E. Sander,Christian Drosten,Sven Laudi,Roland Eils,Roland Eils,Christian Conrad,Ulf Landmesser,Irina Lehmann +39 more
TL;DR: In this paper, the authors observed a distinct inflammatory predisposition of immune cells in patients with hypertension that correlated with critical coronavirus disease 2019 (COVID-19)-related hyperinflammation and increased cell intrinsic antiviral responses, whereas ARB treatment related to enhanced epithelial-immune cell interactions.
Journal ArticleDOI
COVID-19 in cancer patients: clinical characteristics and outcome-an analysis of the LEOSS registry
Maria Rüthrich,C. Giessen-Jung,Stefan Borgmann,Annika Y. Classen,Sebastian Dolff,Beate Grüner,Frank Hanses,Nora Isberner,Philipp Köhler,Julia Lanznaster,Uta Merle,Silvio Nadalin,Christiane Piepel,J. Schneider,J. Schneider,M. Schons,R. Strauss,Lukas Tometten,Jorg-Janne Vehreschild,Jorg-Janne Vehreschild,M. von Lilienfeld-Toal,Gernot Beutel,Kai Wille +22 more
TL;DR: In this paper, the authors present an analysis of cancer patients from the LEOSS (Lean European Open Survey on SARS-CoV-2 Infected Patients) registry to determine whether cancer patients are at higher risk.
References
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Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study.
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Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China
Chaomin Wu,Xiaoyan Chen,Yanping Cai,Jia’an Xia,Xing Zhou,Sha Xu,Han-Ping Huang,Li Zhang,Xia Zhou,Chunling Du,Yuye Zhang,Juan Song,Sijiao Wang,Yencheng Chao,Zeyong Yang,Jie Xu,Xin Zhou,Dechang Chen,Weining Xiong,Lei Xu,Feng Zhou,Jinjun Jiang,Chunxue Bai,Zheng Junhua,Yuanlin Song +24 more
TL;DR: Although high fever was associated with the development of ARDS, it was also associated with better outcomes among patients with ARDS and treatment with methylprednisolone may be beneficial for patients who develop ARDS.
Journal ArticleDOI
Prevalence of comorbidities and its effects in patients infected with SARS-CoV-2: a systematic review and meta-analysis.
Jing Yang,Ya Zheng,Xi Gou,Ke Pu,Zhaofeng Chen,Qinghong Guo,Rui Ji,Haojia Wang,Yuping Wang,Yongning Zhou +9 more
TL;DR: The prevalence of comorbidities in infected patients and risk factors for severe compared with non-severe patients are assessed to help the health sector guide vulnerable populations and assess the risk of deterioration.
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