COVID-19 in cancer patients: clinical characteristics and outcome-an analysis of the LEOSS registry
Maria Rüthrich,C. Giessen-Jung,Stefan Borgmann,Annika Y. Classen,Sebastian Dolff,Beate Grüner,Frank Hanses,Nora Isberner,Philipp Köhler,Julia Lanznaster,Uta Merle,Silvio Nadalin,Christiane Piepel,J. Schneider,J. Schneider,M. Schons,R. Strauss,Lukas Tometten,Jorg-Janne Vehreschild,Jorg-Janne Vehreschild,M. von Lilienfeld-Toal,Gernot Beutel,Kai Wille +22 more
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In this paper, the authors present an analysis of cancer patients from the LEOSS (Lean European Open Survey on SARS-CoV-2 Infected Patients) registry to determine whether cancer patients are at higher risk.Abstract:
Since the early SARS-CoV-2 pandemic, cancer patients have been assumed to be at higher risk for severe COVID-19. Here, we present an analysis of cancer patients from the LEOSS (Lean European Open Survey on SARS-CoV-2 Infected Patients) registry to determine whether cancer patients are at higher risk. We retrospectively analyzed a cohort of 435 cancer patients and 2636 non-cancer patients with confirmed SARS-CoV-2 infection, enrolled between March 16 and August 31, 2020. Data on socio-demographics, comorbidities, cancer-related features and infection course were collected. Age-, sex- and comorbidity-adjusted analysis was performed. Primary endpoint was COVID-19-related mortality. In total, 435 cancer patients were included in our analysis. Commonest age category was 76–85 years (36.5%), and 40.5% were female. Solid tumors were seen in 59% and lymphoma and leukemia in 17.5% and 11% of patients. Of these, 54% had an active malignancy, and 22% had recently received anti-cancer treatments. At detection of SARS-CoV-2, the majority (62.5%) presented with mild symptoms. Progression to severe COVID-19 was seen in 55% and ICU admission in 27.5%. COVID-19-related mortality rate was 22.5%. Male sex, advanced age, and active malignancy were associated with higher death rates. Comparing cancer and non-cancer patients, age distribution and comorbidity differed significantly, as did mortality (14% vs 22.5%, p value < 0.001). After adjustments for other risk factors, mortality was comparable. Comparing cancer and non-cancer patients, outcome of COVID-19 was comparable after adjusting for age, sex, and comorbidity. However, our results emphasize that cancer patients as a group are at higher risk due to advanced age and pre-existing conditions.read more
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Priority COVID-19 Vaccination for Patients with Cancer while Vaccine Supply Is Limited.
Antoni Ribas,Rajarshi Sengupta,Trevan Locke,Sayyed Kaleem Zaidi,Katie M. Campbell,John M. Carethers,Elizabeth M. Jaffee,E. John Wherry,Jean-Charles Soria,Gypsyamber D'Souza +9 more
TL;DR: The available evidence supports the conclusion that patients with cancer, in particular with hematologic malignancies, should be considered among the very high-risk groups for priority COVID-19 vaccination.
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COVID-19 vaccines in patients with cancer: immunogenicity, efficacy and safety
Annika Fendler,Elisabeth G.E. de Vries,Corine H. GeurtsvanKessel,John B. A. G. Haanen,Bernhard Wörmann,Samra Turajlic,Marie von Lilienfeld-Toal +6 more
TL;DR: In this paper , the authors summarize the current knowledge generated in studies conducted since COVID-19 vaccines first became available and highlight critical points that might affect vaccine efficacy in patients with cancer in the future.
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Evaluation of COVID-19 Mortality and Adverse Outcomes in US Patients With or Without Cancer.
TL;DR: In this paper, the outcomes of patients with or without cancer who were diagnosed with COVID-19 and to identify the factors associated with mortality, mechanical ventilation, intensive care unit (ICU) stay, and hospitalization were compared.
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Evaluation of COVID-19 Mortality and Adverse Outcomes in US Patients With or Without Cancer
TL;DR: In this article , the outcomes of patients with or without cancer who were diagnosed with COVID-19 and to identify the factors associated with mortality, mechanical ventilation, intensive care unit (ICU) stay, and hospitalization were compared.
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Outcomes of COVID-19 in Patients With Cancer: Report From the National COVID Cohort Collaborative (N3C).
Noha Sharafeldin,Benjamin Bates,Qianqian Song,Vithal Madhira,Yao Yan,Yao Yan,Sharlene Dong,Eileen Lee,Nathaniel Kuhrt,Yu Raymond Shao,Feifan Liu,Timothy Bergquist,Justin Guinney,Jing Su,Umit Topaloglu +14 more
TL;DR: In this paper, the authors reported variation in risk of adverse clinical outcomes in patients with cancer and COVID-19 has been reported from relatively small cohorts from NCATS' National COVID Cohort Collaborative (N3C).
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