Comparison between 5-day decitabine and 7-day azacitidine for lower-risk myelodysplastic syndromes with poor prognostic features: a retrospective multicentre cohort study.
Byung Hyun Lee,Ka Won Kang,Min Ji Jeon,Eun Sang Yu,Dae Sik Kim,Hojoon Choi,Se Ryeon Lee,Hwa Jung Sung,Byung Soo Kim,Chul Won Choi,Yong Park +10 more
TLDR
In lower-risk MDS, especially with poor prognostic features, ORR and PFS were significantly better with 5-day decitabine treatment than with 7-day azacitidine treatment, with comparable safety.Abstract:
Numerous studies have analysed the clinical efficacies of hypomethylating agents (HMAs) in patients with myelodysplastic syndromes (MDS). However, reports that compare the two HMAs, decitabine and azacitidine, in patients with lower-risk (low and intermediate-1) MDS are limited. We compared 5-day decitabine and 7-day azacitidine regimens in terms of treatment responses, survival outcomes, and adverse events in patients with lower-risk MDS with poor prognostic features. The overall response rates (ORRs) were 67.2% and 44.0% in the patients treated with decitabine and azacitidine, respectively (P = 0.014). While the median progression-free survival (PFS) was significantly better in the patients treated with decitabine than in those treated with azacitidine (P = 0.019), no significant differences in event-free and overall survival rates were observed between the two groups. Multivariate analysis revealed that compared with azacitidine treatment, decitabine treatment is significantly associated with a higher ORR (P = 0.026) and longer PFS (P = 0.037). No significant differences were observed in the incidence of grade 3 or higher haematologic adverse events in response to the two HMAs. In conclusion, in lower-risk MDS, especially with poor prognostic features, ORR and PFS were significantly better with 5-day decitabine treatment than with 7-day azacitidine treatment, with comparable safety.read more
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Hypoplastic Myelodysplastic Syndromes: Just an Overlap Syndrome?
Bruno Fattizzo,Bruno Fattizzo,Fabio Serpenti,Fabio Serpenti,Wilma Barcellini,Chiara Caprioli +5 more
TL;DR: In this paper, a review of the available literature on hypocellular bone marrow (hMDS) is presented, focusing on clinical, immunological, and molecular features, and the authors show that hMDS pathogenesis and clinical presentation are peculiar, albeit in-between aplastic anemia and normo/hypercellular MDS.
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Targeting Epigenetic Modifiers of Tumor Plasticity and Cancer Stem Cell Behavior
Vigneshwari Easwar Kumar,Roshni Nambiar,Cristabelle De Souza,Audrey H. Nguyen,Jeremy Chien,Kit S. Lam +5 more
TL;DR: Various factors governing epigenetic dysregulation of cancer stem cells ranging from the role of epigenetic mediators such as histone and DNA methyltransferases, histone deacetylases, and histone methyl transferases to various signaling pathways associated with cancer stem cell regulation are reviewed.
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Leveraging modeling and simulation to optimize the therapeutic window for epigenetic modifier drugs.
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Evaluation of Reduced-Dose Decitabine and Azacitidine for Treating Myelodysplastic Syndromes: A Retrospective Study.
Naibo Hu,Tiejun Qin,Xiaoyan Du,Bingyi Wang,Xiaoyun Wang,Zefeng Xu,Lijuan Pan,Shiqiang Qu,Zhijian Xiao +8 more
TL;DR: In this article, the effectiveness and safety of reduced-dose azacitidine (AZA) vs. decitabine (DAC) in adult myelodysplastic syndromes (MDS) patients were evaluated.
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Exploring in vitro expression and immune potency in mice using mRNA encoding the Plasmodium falciparum malaria antigen, CelTOS
Ishita N Waghela,Katherine L. Mallory,Justine A. Taylor,Cosette G. Schneider,Tatyana Savransky,Chris J. Janse,Paulo J.C. Lin,Ying K. Tam,Drew Weissman,Evelina Angov +9 more
TL;DR: In this paper , the use of mRNA vaccine technology to induce humoral and cell-mediated immune responses using this antigen was reported, and the results indicated that mRNA transcripts encoding pfceltos while potent for inducing antigen-specific cellular cytokine responses in mice, were less able to mount PfCelTOS-specific antibody responses using a two-dose regimen.
References
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Journal ArticleDOI
International Scoring System for Evaluating Prognosis in Myelodysplastic Syndromes
Peter L. Greenberg,Christopher Cox,Michelle M. LeBeau,Pierre Fenaux,Pierre Morel,Guillermo Sanz,Miguel A. Sanz,Teresa Vallespi,Terry J. Hamblin,David Oscier,Kazuma Ohyashiki,Keisuke Toyama,Carlo Aul,Ghulam J. Mufti,John M. Bennett +14 more
TL;DR: The International MDS Risk Analysis Workshop combined cytogenetic, morphological, and clinical data from seven large previously reported risk-based studies that had generated prognostic systems as discussed by the authors.
Journal ArticleDOI
Revised International Prognostic Scoring System for Myelodysplastic Syndromes
Peter L. Greenberg,Heinz Tuechler,Julie Schanz,Guillermo Sanz,Guillermo Garcia-Manero,Francesc Solé,John M. Bennett,David T. Bowen,Pierre Fenaux,François Dreyfus,Hagop M. Kantarjian,Andrea Kuendgen,Alessandro Levis,Luca Malcovati,Mario Cazzola,Jaroslav Cermak,Christa Fonatsch,Michelle M. Le Beau,Marilyn L. Slovak,Otto Krieger,Michael Luebbert,Jaroslaw P. Maciejewski,Silvia Maria Meira Magalhães,Yasushi Miyazaki,Michael Pfeilstöcker,Mikkael A. Sekeres,Wolfgang R. Sperr,Reinhard Stauder,Sudhir Tauro,Peter Valent,Teresa Vallespi,Arjan A. van de Loosdrecht,Ulrich Germing,Detlef Haase +33 more
TL;DR: This revised IPSS-R comprehensively integrated the numerous known clinical features into a method analyzing MDS patient prognosis more precisely than the initial IPSS and should prove beneficial for predicting the clinical outcomes of untreated MDS patients and aiding design and analysis of clinical trials in this disease.
Journal ArticleDOI
Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label, phase III study.
Pierre Fenaux,Ghulam J. Mufti,Eva Hellström-Lindberg,Valeria Santini,Carlo Finelli,Aristoteles Giagounidis,Robert Schoch,Norbert Gattermann,Guillermo Sanz,Alan F. List,Steven D. Gore,John F. Seymour,John M. Bennett,John C. Byrd,Jay Backstrom,Linda Zimmerman,David McKenzie,C.L. Beach,Lewis R. Silverman +18 more
TL;DR: Treatment with azacitidine increases overall survival in patients with higher-risk myelodysplastic syndromes relative to conventional care.
Journal ArticleDOI
Randomized Controlled Trial of Azacitidine in Patients With the Myelodysplastic Syndrome: A Study of the Cancer and Leukemia Group B
Lewis R. Silverman,Erin P. Demakos,Bercedis L. Peterson,Alice B. Kornblith,Jimmie C. Holland,Rosalie Odchimar-Reissig,Richard Stone,Douglas A. Nelson,Bayard L. Powell,Carlos M. DeCastro,John Ellerton,Richard A. Larson,Charles A. Schiffer,James F. Holland +13 more
TL;DR: Aza C treatment results in significantly higher response rates, improved quality of life, reduced risk of leukemic transformation, and improved survival compared with supportive care.
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