Contributions of T-type calcium channel isoforms to neuronal firing
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In this review the properties of the CaV3.3 T-type channel isoforms is discussed in relation to their individual contributions to action potentials during burst and tonic firing states as well their roles in switching between firing states.Abstract:
Low voltage-activated (LVA) T-type calcium channels play critical roles in the excitability of many cell types and are a focus of research aimed both at understanding the physiological basis of calcium channel-dependent signaling and the underlying pathophysiology associated with hyperexcitability disorders such as epilepsy. These channels play a critical role towards neuronal firing in both conducting calcium ions during action potentials and also in switching neurons between distinct modes of firing. In this review the properties of the CaV3.1, CaV3.2 and CaV3.3 T-type channel isoforms is discussed in relation to their individual contributions to action potentials during burst and tonic firing states as well their roles in switching between firing states.read more
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Targeting voltage-gated calcium channels in neurological and psychiatric diseases
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Thalamocortical Dysrhythmia: A Theoretical Update in Tinnitus
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The Ca(V)3.3 calcium channel is the major sleep spindle pacemaker in thalamus.
Simone Astori,Ralf D. Wimmer,Haydn M. Prosser,Haydn M. Prosser,Corrado Corti,Mauro Corsi,Nicolas Liaudet,Andrea Volterra,Paul Franken,John P. Adelman,Anita Lüthi +10 more
TL;DR: A central role is identified for CaV3.3 channels in the rhythmogenic properties of the sleep-spindle generator and a molecular target is provided to elucidate the roles of sleep spindles for brain function and development.
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Physiology and pathology of calcium signaling in the brain.
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Journal Article
A cav3.2 t-type calcium channel point mutation has splice variant-specific effects on function and segregates with seizure expression in a polygenic rat model of absence epilepsy
Caroline Ng,Kim L. Powell,Stuart M. Cain,S Sirdesai,Laurence S. David,Mervyn Kyi,Esperanza Garcia,John R. Tyson,Christopher A. Reid,Melanie Bahlo,Simon J. Foote,Terrance P. Snutch,Terence J. O'Brien +12 more
TL;DR: In this paper, a homozygous, missense, single nucleotide (G to C) mutation in the Cav3.2 T-type Ca2+ channel gene (Cacna1h) in the genetic absence epilepsy rats from Strasbourg (GAERS) model was described.
References
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International Union of Pharmacology. XLVIII. Nomenclature and Structure-Function Relationships of Voltage-Gated Calcium Channels
TL;DR: The molecular relationships and physiological functions of these calcium channel proteins are presented and comprehensive information on their molecular, genetic, physiological, and pharmacological properties is provided.
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Molecular Physiology of Low-Voltage-Activated T-type Calcium Channels
TL;DR: The goal of this review is to provide a comprehensive description of T-type currents, their distribution, regulation, pharmacology, and cloning.
Journal ArticleDOI
A low voltage-activated, fully inactivating Ca channel in vertebrate sensory neurones
Emilio Carbone,H. D. Lux +1 more
TL;DR: Evidence is presented for a new type of Ca channel with time- and voltage-dependent properties which is probably responsible for the inactivation behaviour of the Ca conductance and coexists in isolated membrane patches with the more common Ca channel4 which shows a considerably shorter average life time and smaller currents.
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Differential distribution of three members of a gene family encoding low voltage-activated (T-type) calcium channels.
Edmund M. Talley,Leanne L. Cribbs,Jung-Ha Lee,Asif N. Daud,Edward Perez-Reyes,Douglas A. Bayliss +5 more
TL;DR: In this paper, localized central and peripheral nervous system expression of three transcripts (α1G, α1H, and α1I) of the T-type calcium channel family (CaVT) was found.
Journal ArticleDOI
Electrophysiology of mammalian thalamic neurones in vitro
Rodolfo R. Llinás,Henrik Jahnsen +1 more
TL;DR: Evidence is presented that thalamic neurones have voltage-sensitive ionic conductances capable of generating two distinct functional states—a repetitive and a burst-firing mode.